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Akademický článek

Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

Abstract Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn’s disease (CD) and ulcerative colitis (UC) predisposes t

Externí odkaz: https://doaj.org/article/46e01ed1d0cc4b39bd52631c3a872a9b

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The Fornax Deep Survey with VST. VII. Evolution and Structure of Late Type Galaxies inside the Virial Radius of the Fornax Cluster

Autor: Raj, M. A., Iodice, E., Napolitano, N. R., Spavone, M., Su, H-S., Peletier, R. F., Davis, T. A., Zabel, N., Hilker, M., Mieske, S., Barroso, J. Falcon, Cantiello, M., van de Ven, G., Watkins, A. E., Salo, H., Schipani, P., Capaccioli, M., Venhola, A.

Publikováno v: A&A 628, A4 (2019)

We present the study of a magnitude limited sample (mB < 16.6 mag) of 13 late type galaxies (LTGs), observed inside the virial radius, Rvir 0.7 Mpc, of the Fornax cluster within the Fornax Deep Survey (FDS). The main objective is to use surface brigh

Externí odkaz: http://arxiv.org/abs/1906.08704

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Resolving galaxies in time and space: II: Uncertainties in the spectral synthesis of datacubes

Autor: Fernandes, R. Cid, Delgado, R. M. Gonzalez, Benito, R. Garcia, Perez, E., de Amorim, A. L., Sanchez, S. F., Husemann, B., Barroso, J. Falcon, Lopez-Fernandez, R., Sanchez-Blazquez, P., Asari, N. Vale, Vazdekis, A., Walcher, C. J., Mast, D.

In a companion paper we have presented many products derived from the application of the spectral synthesis code STARLIGHT to datacubes from the CALIFA survey, including 2D maps of stellar population properties and 1D averages in the temporal and spa

Externí odkaz: http://arxiv.org/abs/1307.0562

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Resolving galaxies in time and space: I: Applying STARLIGHT to CALIFA data cubes

Autor: Fernandes, R. Cid, Perez, E., Benito, R. Garcia, Delgado, R. M. Gonzalez, de Amorim, A. L., Sanchez, S. F., Husemann, B., Barroso, J. Falcon, Sanchez-Blazquez, P., Walcher, C. J., Mast, D.

Fossil record methods based on spectral synthesis techniques have matured over the past decade, and their application to integrated galaxy spectra fostered substantial advances on the understanding of galaxies and their evolution. Yet, because of the

Externí odkaz: http://arxiv.org/abs/1304.5788

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Akademický článek

Response to Immune Checkpoint Inhibition as Monotherapy or in Combination With Chemotherapy in Metastatic ROS1-Rearranged Lung Cancers

Autor: Noura J. Choudhury, MD, Jaime L. Schneider, MD, PhD, Tejas Patil, MD, Viola W. Zhu, MD, PhD, Debra A. Goldman, MS, Soo-Ryum Yang, MD, Christina J. Falcon, MPH, Andrew Do, BS, Yunan Nie, MD, Andrew J. Plodkowski, MD, Jamie E. Chaft, MD, Subba R. Digumarthy, MD, Natasha Rekhtman, MD, PhD, Maria E. Arcila, MD, Alexia Iasonos, PhD, Sai-Hong I. Ou, MD, PhD, Jessica J. Lin, MD, Alexander Drilon, MD

Publikováno v: JTO Clinical and Research Reports, Vol 2, Iss 7, Pp 100187- (2021)

Introduction: ROS1 fusions are oncogenic drivers in 1% to 3% of NSCLCs. The activity of immune checkpoint inhibitor (ICI) monotherapy or in combination with chemotherapy (chemotherapy with ICI [chemo-ICI]) in these tumors and their immunophenotype ha

Externí odkaz: https://doaj.org/article/81bc0a6f5dc849f182e47505ceaaaec1

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Molecular Biomarkers of Disease Outcomes and Mechanisms of Acquired Resistance to First-Line Osimertinib in Advanced EGFR-Mutant Lung Cancers

Autor: Noura J. Choudhury, Antonio Marra, Jane S.Y. Sui, Jessica Flynn, Soo-Ryum Yang, Christina J. Falcon, Pier Selenica, Adam J. Schoenfeld, Natasha Rekhtman, Daniel Gomez, Michael F. Berger, Marc Ladanyi, Maria Arcila, Charles M. Rudin, Gregory J. Riely, Mark G. Kris, Glenn Heller, Jorge S. Reis-Filho, Helena A. Yu

Publikováno v: Journal of Thoracic Oncology. 18:463-475

Preferred first-line treatment for patients with metastatic EGFR-mutant lung cancer is osimertinib, yet it is not known if patient outcomes may be improved by identifying and intervening upon molecular markers associated with therapeutic resistance.A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c319c80baa5ae91d6606cbab73e1f761
https://doi.org/10.1016/j.jtho.2022.11.022

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Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant MET Copy Number Alterations in >50,000 Tumors

Autor: James P. Solomon, Soo-Ryum Yang, Noura J. Choudhury, Ryan N. Ptashkin, Nasrin Eslamdoost, Christina J. Falcon, Axel Martin, Andrew Plodkowski, Clare Wilhelm, Ronglai Shen, Marc Ladanyi, Michael Berger, Yanming Zhang, Alexander Drilon, Maria E. Arcila

Publikováno v: Clin Cancer Res

Purpose: Clinical relevance thresholds and laboratory methods are poorly defined for MET amplification, a targetable biomarker across malignancies. Experimental Design: The utility of next-generation sequencing (NGS) in assessing MET copy number alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05b31989372c86c1dd9b5930da84d1d
https://doi.org/10.1158/1078-0432.ccr-22-1321

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