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Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma

Autor: Krzysztof Sładek, F K Austen, B K Lam, Adamek L, Andrzej Szczeklik, Jerzy Soja, J F Penrose, E. Nizankowska, Stephen T. Holgate, Andrew S. Cowburn, A P Sampson

Publikováno v: Journal of Clinical Investigation. 101:834-846

Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering cysteinyl-leukotriene (cys-LT) production, probably by removing PGE2-dependent inhibition. To investigate why aspirin does not cause bronchoconstriction in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea318a715b59c291fa1f8d0498d601af
https://doi.org/10.1172/jci620

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Expression of LTC4 synthase during the development of eosinophils in vitro from cord blood progenitors

Autor: J A, Boyce, B K, Lam, J F, Penrose, D S, Friend, S, Parsons, W F, Owen, K F, Austen

Publikováno v: Blood. 88:4338-4347

The expression of leukotriene C4 synthase (LTC4S) was examined during the development of eosinophils in vitro from cord blood mononuclear cells. At 7 days, the cells contained mRNA and sodium dodecyl sulfate-polyacrylamide gel electrophoresis immunob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84275afdf3f032d0fbb00635ca8dc7c8
https://doi.org/10.1182/blood.v88.11.4338.bloodjournal88114338

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Purification of human leukotriene C4 synthase

Autor: P Myers, L Gagnon, Roy J. Soberman, J F Penrose, R. M. Jack, Bing K. Lam, K F Austen, M Goppelt-Struebe

Publikováno v: Proceedings of the National Academy of Sciences. 89:11603-11606

Leukotriene (LT) C4 synthase, the enzyme that catalyzes the conjugation of LTA4 with reduced glutathione to form LTC4, was purified to homogeneity from the KG-1 myeloid cell line after solubilization of the microsomes utilizing a combination of 0.4%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3edff005c0ef10fb1226b83e360e10
https://doi.org/10.1073/pnas.89.23.11603

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Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35

Autor: J F, Penrose, J, Spector, M, Baldasaro, K, Xu, J, Boyce, J P, Arm, K F, Austen, B K, Lam

Publikováno v: The Journal of biological chemistry. 271(19)

Leukotriene C4 (LTC4) synthase catalyzes the conjugation of LTA4 with reduced GSH to form LTC4, the parent of the receptor active cysteinyl leukotrienes implicated in the pathobiology of bronchial asthma. Previous cloning of the cDNA for human LTC4 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e111fa89ee32ae131bb10300ea45c92
https://pubmed.ncbi.nlm.nih.gov/8626689

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