Zobrazeno 1 - 10
of 315
pro vyhledávání: '"J F P Luiken"'
Autor:
Tom Houben, Tulasi Yadati, Robbin de Kruijf, Marion J. J. Gijbels, Joost J. F. P. Luiken, Marc van Zandvoort, Dimitris Kapsokalyvas, Dieter Lütjohann, Marit Westerterp, Jogchum Plat, David Leake, Ronit Shiri-Sverdlov
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Lifestyle- and genetically induced disorders related to disturbances in cholesterol metabolism have shown the detrimental impact of excessive cholesterol levels on a plethora of pathological processes such as inflammation. In this context, two-hydrox
Externí odkaz:
https://doaj.org/article/bbd2929920734dc38c17c39f7b117938
Autor:
Shujin Wang, Yinying Han, Miranda Nabben, Dietbert Neumann, Joost J. F. P. Luiken, Jan F. C. Glatz
Publikováno v:
Metabolites, Vol 12, Iss 7, p 579 (2022)
The heart is a metabolically flexible omnivore that can utilize a variety of substrates for energy provision. To fulfill cardiac energy requirements, the healthy adult heart mainly uses long-chain fatty acids and glucose in a balanced manner, but whe
Externí odkaz:
https://doaj.org/article/6173d029ddd14f3fb7f60a593e9606ca
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
Abstract The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial t
Externí odkaz:
https://doaj.org/article/dd4037f3343f46c6953443e625a00e6c
Autor:
Yilin Liu, Ricardo Rodriguez-Calvo, Shujin Wang, Xiaoqing Zhu, Jos L V Broers, Jan F C Glatz, Joost J F P Luiken, Dietbert Neumann
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210704 (2019)
ContextUpon palmitate oversupply, membrane fatty acid-transporter CD36 (SR-B2) permanently translocates from endosomal storage to the sarcolemma, inducing lipotoxicity. CD36 translocation results from endosomal alkalinisation elicited by palmitate-in
Externí odkaz:
https://doaj.org/article/436ea3e4f183458dba5b715010026dcf
Publikováno v:
Current Opinion in Lipidology. 33:103-111
PURPOSE OF REVIEW: Transmembrane glycoprotein cluster of differentiation 36 (CD36) is a scavenger receptor class B protein (SR-B2) that serves various functions in lipid metabolism and signaling, in particular facilitating the cellular uptake of long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b5e297cb12aee7226537993ec18dc3
https://doi.org/10.1097/mol.0000000000000819
https://doi.org/10.1097/mol.0000000000000819
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Protein kinase-D (PKD) is increasingly recognized as a key regulatory signaling hub in cardiac glucose uptake and also a major player in the development of hypertrophy. Glucose is one of the predominant energy substrates for the heart to support cont
Externí odkaz:
https://doaj.org/article/94adcf5ea1fe4bad8470cdf130210247
Autor:
Shujin Wang, Dietbert Neumann, B. Daan Westenbrink, Francesco Schianchi, Li-Yen Wong, Aomin Sun, Agnieszka Strzelecka, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12909
International Journal of Molecular Sciences, 23(21):12909. MDPI AG
International journal of molecular sciences, 23(21):12909. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 23(21):12909. MDPI AG
International journal of molecular sciences, 23(21):12909. Multidisciplinary Digital Publishing Institute (MDPI)
The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271271f426d3b4ebb25cd7ea28570770
Autor:
S L V M Stroeks, J A J Verdonschot, I G Lunde, M T H M Henkens, M Willemars, F Schianchi, J F P Luiken, P Wang, K Derks, I P C Krapels, E K Vanhoutte, E A V Jones, H G Brunner, M Nabben, S R B Heymans
Publikováno v:
European Heart Journal. 43
Background/Objectives Titin truncating variants (TTNtv) are the most prevalent genetic cause of dilated cardiomyopathy (DCM), resulting in upregulation of cardiac transcripts of oxidative phosphorylation (1,2). However, the underlying molecular mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c943dff3c44f936cd23715434780ef4c
https://doi.org/10.1093/eurheartj/ehac544.758
https://doi.org/10.1093/eurheartj/ehac544.758
Autor:
Patricia Garcia-Canadilla, Jose F Rodriguez, Maria J Palazzi, Anna Gonzalez-Tendero, Patrick Schönleitner, Vedrana Balicevic, Sven Loncaric, Joost J F P Luiken, Mario Ceresa, Oscar Camara, Gudrun Antoons, Fatima Crispi, Eduard Gratacos, Bart Bijnens
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182915 (2017)
Experimental studies on isolated cardiomyocytes from different animal species and human hearts have demonstrated that there are regional differences in the Ca2+ release, Ca2+ decay and sarcomere deformation. Local deformation heterogeneities can occu
Externí odkaz:
https://doaj.org/article/c1b320ee731b44e38332c55f99974972
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:393-400
Introduction: Disturbances in myocardial lipid metabolism are increasingly being recognized as drivers of the development and progression of heart disease. Therefore, there is a need for treatments that can directly target lipid metabolic defects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae052bd0dfb52aabfe89b0ac401e1c5
https://doi.org/10.1080/14728222.2021.1941865
https://doi.org/10.1080/14728222.2021.1941865