Zobrazeno 1 - 10 of 27 pro vyhledávání: '"J F Johnston"'
1
Detection of progesterone receptor forms A and B by immunohistochemical analysis
Autor: T Manninen, Patricia A. Mote, P Tuohimaa, J F Johnston, Christine L. Clarke
Publikováno v: Journal of Clinical Pathology. 54:624-630
Aim—The measurement of progesterone receptors (PR) is recommended as part of the clinical management of breast and endometrial cancers, and immunohistochemistry on formalin fixed tissue is now the method of choice. PR is expressed as two isoforms,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a144edcb0a7cc5841575712f7d2d186
https://doi.org/10.1136/jcp.54.8.624
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2
Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway
Autor: Mikhail V. Blagosklonny, Leonard M. Neckers, J F Johnston, J F Mushinski, B P Monia, Phuongmai Nguyen, Jane B. Trepel, L Romanova, T W Schulte
Publikováno v: Molecular and Cellular Biology. 16:5839-5845
The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus. Raf-1 integrates signals coming from extracellular factors and, in turn, activa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbc71d637aea21af62ae7b6a214024e
https://doi.org/10.1128/mcb.16.10.5839
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7
A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma
Autor: C C, Cunningham, J T, Holmlund, R S, Geary, T J, Kwoh, A, Dorr, J F, Johnston, B, Monia, J, Nemunaitis
Publikováno v: Cancer. 92(5)
Abnormal expression of Ras proteins frequently is found with oncogenic transformation making ras a promising therapeutic target. ISIS 2503 is a 20-base antisense phosphorothioate oligodeoxyribonucleotide that specifically downregulates H-ras expressi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4045a3bbb97dc24d2076dd3146673644
https://pubmed.ncbi.nlm.nih.gov/11571742
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8
Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer
Autor: C M, Rudin, J, Holmlund, G F, Fleming, S, Mani, W M, Stadler, P, Schumm, B P, Monia, J F, Johnston, R, Geary, R Z, Yu, T J, Kwoh, F A, Dorr, M J, Ratain
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5)
Raf-1 is a serine/threonine kinase that functions as a critical effector of Ras-mediated signal transduction via the mitogen-activated protein kinase pathway. Constitutive activation of this pathway directly contributes to malignant transformation in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e609cbabf84a1bf95a72e2ff7662b333
https://pubmed.ncbi.nlm.nih.gov/11350886
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9
Inhibition of C-raf expression by antisense oligonucleotides extends heart allograft survival in rats
Autor: S M, Stepkowski, X, Qu, M E, Wang, L, Tian, W, Chen, E V, Wancewicz, J F, Johnston, C F, Bennett, B P, Monia
Publikováno v: Transplantation. 70(4)
C-raf is a well-characterized serine/ threonine (Ser/Thr) protein kinase that is involved in the transduction of multiple signals of T cells. We demonstrate that the inhibition of C-raf mRNA expression prolongs heart allograft survival.Three 20-mer C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1b3b9648745d021f46a6bf9ca50d91b
https://pubmed.ncbi.nlm.nih.gov/10972225
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10
Selective inhibition of A-Raf and C-Raf mRNA expression by antisense oligodeoxynucleotides in rat vascular smooth muscle cells: role of A-Raf and C-Raf in serum-induced proliferation
Autor: C L, Cioffi, M, Garay, J F, Johnston, K, McGraw, R T, Boggs, D, Hreniuk, B P, Monia
Publikováno v: Molecular pharmacology. 51(3)
Raf kinases, cytoplasmic serine/threonine protein kinases, have been proposed as important participants in mitogen-induced signal transduction. However, the precise role that Raf kinase isozymes play in cellular responses such as proliferation has no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ecccb9ab624115bd51c7560a3da10fd
https://pubmed.ncbi.nlm.nih.gov/9058592
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