Zobrazeno 1 - 10
of 10
pro vyhledávání: '"J F, Sina"'
Autor:
P. D. Gautheron, J. F. Sina
Publikováno v:
Toxicology Methods. 4:41-49
Given the number of components scored in the Draize test and the diverse mechanisms leading to distinct clinical signs (opacity, inflammation, necrosis, etc.), no single-endpoint in vitro test is likely to suffice to predict ocular irritation potenti
Autor:
J F, Sina
Publikováno v:
In Vitro & Molecular Toxicology. 13:85-87
Autor:
J F, Sina
Publikováno v:
In vitromolecular toxicology. 13(4)
Autor:
J F, Sina
Publikováno v:
In vitromolecular toxicology. 13(1)
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 35(1)
As part of the Interagency Regulatory Alternatives Group (IRAG) program to evaluate the state of the art in the development of alternative (non-whole animal) eye irritation tests, academic and industrial organizations were invited to submit in vitro
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 18(3)
Most of the published in vitro tests of ocular irritancy investigate a single parameter, generally cytotoxicity, using different cell types in culture. Although good correlations with in vivo data have been reported by some investigators, many of the
Publikováno v:
Cancer research. 43(9)
To better understand the progression of epithelial cells from a normal to a malignant phenotype, we have compared various responses of normal, preneoplastic, and neoplastic hamster epidermal cells to the tumor promoter 12-O-tetradecanoylphorbol-13-ac
Publikováno v:
Cancer research. 43(1)
Primary cultures of hamster epidermal cells exposed to hydrocarbon, 1 microgram/ml, rapidly metabolized [3H]benzo(a)pyrene and [14C]7,12-dimethylbenz(a)anthracene to ethyl acetate:acetone- and water-soluble metabolites. By 24 hr, only 13.6% of the or
Publikováno v:
Cancer research. 46(3)
We have investigated whether the activation of endogenous ras genes is associated with the immortalization or malignant transformation of primary hamster epidermal cells by chemical carcinogens. We have also asked whether transfection of a cloned c-H
Autor:
Bruce Chin, J. F. Sina
Publikováno v:
Micron (1969). 10:191-192