Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J F, Sambrook"'
Publikováno v:
Thrombosis and Haemostasis. 71:124-128
SummaryPlatelet-rich clots are inefficiently lysed by current fibrinolytic agents. Platelets contain a great deal of plasminogen activator inhibitor 1 (PAI-1), the principal endogenous inhibitor of tissue-type plasminogen activator (t-PA). We have te
Autor:
Tetsu Kamitani, R. DeGasperi, Hui Ming Chang, Peter Orlean, Masaharu Urakaze, Eiji Sugiyama, J F Sambrook, Lawrence J. Thomas, Christopher D. Warren, P J Beck
Publikováno v:
Journal of Biological Chemistry. 266:23175-23184
The glycosylphosphatidylinositol (GPI) anchor, potentially capable of generating a number of second messengers, such as diacylglycerol, phosphatidic acid, and inositol phosphate glycan, has been postulated to be involved in signal transduction in var
Autor:
F, Wiradjaja, L M, Ooms, J C, Whisstock, B, McColl, L, Helfenbaum, J F, Sambrook, M J, Gething, C A, Mitchell
Publikováno v:
The Journal of biological chemistry. 276(10)
The budding yeast Saccharomyces cerevisiae has four inositol polyphosphate 5-phosphatase (5-phosphatase) genes, INP51, INP52, INP53, and INP54, all of which hydrolyze phosphatidylinositol (4,5)-bisphosphate. INP54 encodes a protein of 44 kDa which co
Publikováno v:
The Journal of biological chemistry. 269(48)
We have studied the binding of synthetic peptides to three hsp70 molecular chaperones, DnaK, BiP, and hsc70, as a model for the interaction of hsp70 proteins with unfolded regions of target polypeptides. We measured the ability of 53 peptides to inhi
Publikováno v:
The Journal of biological chemistry. 269(43)
Human small intestinal lactase-phlorizin hydrolase (LPH) is synthesized as a single-chain polypeptide precursor, prepro-LPH, that undergoes two sequential cleavage steps: the first in the endoplasmic reticulum to pro-LPH (215-kDa) and the second, fol
Autor:
R, Anand, D, Ma, H, Alizadeh, S A, Comerford, J F, Sambrook, M J, Gething, I W, McLean, J Y, Niederkorn
Publikováno v:
Investigative ophthalmologyvisual science. 35(9)
To characterize intraocular tumors that arise by in situ transformation in the choroid-retinal pigment epithelium (RPE) in transgenic mice bearing the SV40 oncogene under the control of the mouse tyrosinase promoter.Tumors from TySV40 transgenic mice
Publikováno v:
Thrombosis and haemostasis. 71(1)
Platelet-rich clots are inefficiently lysed by current fibrinolytic agents. Platelets contain a great deal of plasminogen activator inhibitor 1 (PAI-1), the principal endogenous inhibitor of tissue-type plasminogen activator (t-PA). We have tested wh
Autor:
L J, Thomas, R, DeGasperi, E, Sugiyama, H M, Chang, P J, Beck, P, Orlean, M, Urakaze, T, Kamitani, J F, Sambrook, C D, Warren
Publikováno v:
The Journal of biological chemistry. 266(34)
The glycosylphosphatidylinositol (GPI) anchor, potentially capable of generating a number of second messengers, such as diacylglycerol, phosphatidic acid, and inositol phosphate glycan, has been postulated to be involved in signal transduction in var
Publikováno v:
The Journal of biological chemistry. 266(19)
Lactase-phlorizin hydrolase (LPH) (EC 3.2.1.23/62) is a major intestinal microvillar membrane glycoprotein that digests lactose, the main carbohydrate of milk. To investigate structure/function relationships of LPH and to assess the impact of intrace
Publikováno v:
The Journal of biological chemistry. 265(35)
Tissue-type plasminogen activator (t-PA) catalyzes the rate-limiting step in the fibrinolytic cascade: conversion of plasminogen to plasmin. Plasma contains several inhibitors of t-PA that limit its activity and prevent systemic activation of plasmin