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Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells

Autor: J F Rowell, A L Ruff, F G Guarnieri, K Staveley-O'Carroll, X Lin, J Tang, J T August, R F Siliciano

Publikováno v: The Journal of Immunology. 155:1818-1828

A subset of endogenously synthesized Ags can be processed for class II-restricted presentation, probably through multiple mechanisms. Processing of exogenous Ags for class II-restricted presentation appears to occur in unique endosomal processing com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cf7c396e3526b297437f9b0b5148695
https://doi.org/10.4049/jimmunol.155.4.1818

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Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC

Autor: J F Rowell, P E Stanhope, R F Siliciano

Publikováno v: The Journal of Immunology. 155:473-488

CD4+ T cell clones specific for the HIV-1 envelope (env) protein are able to recognize not only uninfected APC that have taken up and processed exogenous env protein, but also virally infected cells expressing the env protein. We have evaluated the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62c3e8de8f1259aff1069d5bad154d19
https://doi.org/10.4049/jimmunol.155.1.473

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HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes

Autor: K M Callahan, J F Rowell, M J Soloski, C E Machamer, R F Siliciano

Publikováno v: The Journal of Immunology. 151:2928-2942

T lymphocytes are activated upon binding of their Ag receptors to a complex of Ag-derived peptides and MHC class I or class II molecules expressed on the surface of APC. It is now well established that APC degrade exogenous Ag in acidic endosomal com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3155a34fa9e4531d17191f70dc0e1c9e
https://doi.org/10.4049/jimmunol.151.6.2928

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The inflammatory response to nonfatal Sindbis virus infection of the nervous system is more severe in SJL than in BALB/c mice and is associated with low levels of IL-4 mRNA and high levels of IL-10-producing CD4+ T cells

Autor: J F, Rowell, D E, Griffin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(3)

SJL mice are susceptible to inflammatory autoimmune diseases of the central nervous system (CNS), while BALB/c mice are relatively resistant. To understand differences in immune responses that may contribute to autoimmune neurologic disease, we compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a8ca4ad11bc9a603205d4e911f53970d
https://pubmed.ncbi.nlm.nih.gov/9973422

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Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells

Autor: J F, Rowell, A L, Ruff, F G, Guarnieri, K, Staveley-O'Carroll, X, Lin, J, Tang, J T, August, R F, Siliciano

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 155(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e20c04cc035b2a2f615403c1e440b07
https://pubmed.ncbi.nlm.nih.gov/7636236

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HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes

Autor: K M, Callahan, J F, Rowell, M J, Soloski, C E, Machamer, R F, Siliciano

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 151(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::926022fd3713c3b52328db3823c7bb62
https://pubmed.ncbi.nlm.nih.gov/8376762

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