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1,1,3,3-tetrachloroacetone: teratogenicity study in mice and rabbits

Autor: J A, John, F J, Murray, J F, Quast, P A, Keeler, B A, Schwetz, R E, Staples

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 2(5)

The teratogenicity of tetrachloroacetone (TCA) was evaluated in CF-1 mice and New Zealand white rabbits. Mice were given 0, 5, 15 or 50 mg/kg/day of TCA by gavage on days 6 through 15 of gestation. Rabbits were given 0, 1, 5, or 10 mg/kg/day on days

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cbd1ad48af6c4e68fa5e999e5889ba6
https://pubmed.ncbi.nlm.nih.gov/7185619

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Pharmacokinetics and macromolecular interactions of ethylene dichloride in rats after inhalation or gavage

Autor: R H, Reitz, T R, Fox, J C, Ramsey, J F, Quast, P W, Langvardt, P G, Watanabe

Publikováno v: Toxicology and applied pharmacology. 62(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6dc6a9a07b86a195374ac2682571dc5e
https://pubmed.ncbi.nlm.nih.gov/7058523

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Neurotoxicologic examination of rats dermally exposed to 2,4-D amine for three weeks

Autor: J L, Mattsson, R R, Albee, K A, Johnson, J F, Quast

Publikováno v: Neurobehavioral toxicology and teratology. 8(3)

There was no evidence of peripheral neuropathy or other neurotoxicity in rats dermally treated with a 12% aqueous solution of the amine salt of 2,4-dichlorophenoxyacetic acid (2,4-D amine). Male and female Fischer 344 rats were treated on the skin of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2252120e8cdf22ce4a297513d7423b62
https://pubmed.ncbi.nlm.nih.gov/3736754

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Teratologic evaluation of 2-phenoxyethanol in New Zealand White rabbits following dermal exposure

Autor: B H, Scortichini, J F, Quast, K S, Rao

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 8(2)

2-Phenoxyethanol was applied to the clipped skin of pregnant rabbits on Days 6 through 18 of gestation in order to assess the fetotoxic and teratogenic potential by the dermal route. Rabbits were treated with 0, 300, 600, or 1000 mg/kg/day of 2-pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da0313602b6735f8e6550d5f025b2ca4
https://pubmed.ncbi.nlm.nih.gov/3556838

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Embryotoxicity of inhaled sulfuric acid aerosol in mice and rabbits

Autor: F J, Murray, B A, Schwetz, K D, Nitschke, A A, Crawford, J F, Quast, R E, Staples

Publikováno v: Journal of environmental science and health. Part C: Environmental health sciences. 13(3)

The effect of inhaled sulfuric acid (H2SO4) on embryonal and fetal development was assessed in CF-1 mice and in New Zealand white rabbits. Both species were exposed for 7 hr/day to 0, 5, or 20 mg H2SO4/m3 during the period of major organogenesis (mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8164de2ee1e13478488eb5db086a497b
https://pubmed.ncbi.nlm.nih.gov/555467

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Teratologic evaluation of dermally applied diethylene glycol monomethyl ether in rabbits

Autor: B H, Scortichini, J A, John-Greene, J F, Quast, K S, Rao

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 7(1)

Diethylene glycol monomethyl ether (DEGME) was applied to the skin of pregnant rabbits on Days 6 through 18 of gestation in order to assess the fetotoxic and teratogenic potential by the dermal route. Rabbits were treated with 0, 50, 250, or 750 mg/k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3cd02f7bd68336d767555be87767e4b4
https://pubmed.ncbi.nlm.nih.gov/3732673

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Non-linear pharmacokinetic parameters need to be considered in high dose/low dose extrapolation

Autor: R H, Reitz, J F, Quast, A M, Schumann, P G, Watanabe, P J, Gehring

Publikováno v: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 3

It is impossible to prove that any chemical, natural or man-made, cannot cause cancer in man. However, it is possible to estimate the relative degrees of risk associated with various agents. The precision of these estimations increases as experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f92a9ac76959bf0507fff8c579d2471
https://pubmed.ncbi.nlm.nih.gov/6930952

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