Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J F, Parkinson"'
Publikováno v:
The Journal of Immunology. 158:2940-2946
Aminoguanidine (AG), a selective inhibitor of inducible nitric oxide synthase, prevented the clinical development of experimental autoimmune encephalomyelitis (EAE) with a reduction in inflammation and demyelination. Administration of AG reduced the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d03369cd7337a31b94867016db16b50c
https://doi.org/10.4049/jimmunol.158.6.2940
https://doi.org/10.4049/jimmunol.158.6.2940
Publikováno v:
Biochemical Journal. 295:131-140
Thrombomodulin (TM) is an endothelial cell thrombin receptor that converts thrombin from a procoagulant to an anticoagulant enzyme. It has previously been shown that TM is expressed in both a high-M(r) form containing chondroitin sulphate and a low-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fec7411ec15d0be77c8a7580dc4f9d
https://doi.org/10.1042/bj2950131
https://doi.org/10.1042/bj2950131
Publikováno v:
Journal of Biological Chemistry. 265:12602-12610
Thrombomodulin is an endothelial cell membrane protein which plays a central regulatory role in the protein C anticoagulant pathway. The human thrombomodulin intronless gene was isolated from a genomic DNA library and used to isolate the coding regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2f85aeed1da978316c6e6f6528efac
https://doi.org/10.1016/s0021-9258(19)38386-3
https://doi.org/10.1016/s0021-9258(19)38386-3
Autor:
J. F. Parkinson
Publikováno v:
Nitric Oxide ISBN: 9783642630262
The purpose of the current review is to provide the interested investigator with an overview of the most recent advances in the identification, design and development of mechanism-based nitric-oxide synthase (NOS) inhibitors. A thorough review of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcc7822dc946ef91ef842ad53a092d0
https://doi.org/10.1007/978-3-642-57077-3_6
https://doi.org/10.1007/978-3-642-57077-3_6
Autor:
H, Li, C S, Raman, C B, Glaser, E, Blasko, T A, Young, J F, Parkinson, M, Whitlow, T L, Poulos
Publikováno v:
The Journal of biological chemistry. 274(30)
The crystal structures of the heme domain of human inducible nitric-oxide synthase (NOS-2) in zinc-free and -bound states have been solved. In the zinc-free structure, two symmetry-related cysteine residues form a disulfide bond. In the zinc-bound st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9592c1388396ff396280cc29a227cbe
https://pubmed.ncbi.nlm.nih.gov/10409685
https://pubmed.ncbi.nlm.nih.gov/10409685
Autor:
M, Ding, B A, St Pierre, J F, Parkinson, P, Medberry, J L, Wong, N E, Rogers, L J, Ignarro, J E, Merrill
Publikováno v:
The Journal of biological chemistry. 272(17)
The understanding of the induction and regulation of inducible nitric-oxide synthase (iNOS) in human cells may be important in developing therapeutic interventions for inflammatory diseases. In the present study, we not only demonstrated that human f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8870df0e42ef69f90e9287338b85563
https://pubmed.ncbi.nlm.nih.gov/9111039
https://pubmed.ncbi.nlm.nih.gov/9111039
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(6)
Aminoguanidine (AG), a selective inhibitor of inducible nitric oxide synthase, prevented the clinical development of experimental autoimmune encephalomyelitis (EAE) with a reduction in inflammation and demyelination. Administration of AG reduced the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::daee0c5939b01c247678aa10b31e595c
https://pubmed.ncbi.nlm.nih.gov/9058833
https://pubmed.ncbi.nlm.nih.gov/9058833
Autor:
J. F. Parkinson
Publikováno v:
Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones ISBN: 9783662035054
The L-arginine/nitric oxide (NO•) pathway is now recognized as a key physiological and pathophysiological mediator of many biological processes including vascular, neurologic and immune function (Nathan 1992; Feldman et al. 1993a; Bredt and Snyder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb80d96177a2b316e1e0bba1a166fef7
https://doi.org/10.1007/978-3-662-03503-0_1
https://doi.org/10.1007/978-3-662-03503-0_1
Publikováno v:
Biochemical Journal, 3, 290, 655-659
Thrombomodulin (TM), a membrane proteoglycan on endothelial cells, binds thrombin in a 1:1 complex, accelerates the protein C activation by thrombin, promotes the thrombin inactivation by antithrombin III and inhibits the procoagulant properties of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d112d28662e8a10f64b32c26aa2ed6a
https://europepmc.org/articles/PMC1132330/
https://europepmc.org/articles/PMC1132330/