Výsledky vyhledávání - "J F, Matejovic"

DNA-targeted 2-nitroimidazoles: in vitro and in vivo studies

Autor: Andrew M. Rauth, David S.M. Cowan, R. A. Mcclelland, J. F. Matejovic

Publikováno v: British Journal of Cancer

A series of compounds in which a 2-nitroimidazole is linked to a DNA intercalating phenanthridine moiety has been synthesised. Previously, three such compounds, termed nitroimidazole-linked phenanthridines or NLPs, were tested in vitro and showed a g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68349d85938aedcc262e95fe7ceca0c
http://europepmc.org/articles/PMC2033674

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Radiosensitizing and cytotoxic properties of DNA targeted phenanthridine-linked nitroheterocycles of varying electron affinities

Autor: D S, Cowan, J F, Matejovic, P, Wardman, R A, McClelland, A M, Rauth

Publikováno v: International journal of radiation biology. 66(6)

2-Nitroimidazoles targeted to DNA via intercalation have previously been shown to be as much as 10-100 times more efficient on a molar basis than the untargeted nitroimidazole, misonidazole, in vitro as hypoxic cell selective radiosensitizers and cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6bef23686c5d9e05aae236701bd05e5
https://pubmed.ncbi.nlm.nih.gov/7814971

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