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Designing Animal Models of Alzheimer's Disease with Amyloid Precursor Protein (APP) Transgenes

Autor: J F, Loring

Publikováno v: Methods in molecular medicine. 32

Amyloid precursor protein (APP) and Alzheimer's disease are irrevocably linked, as APP is cleaved to form the Aβ peptides that are the major components of amyloid plaques. One of the most resilient hypotheses about the cause of AD centers on the Aβ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46b9c454c46e873d2e1d288175d76d3f
https://pubmed.ncbi.nlm.nih.gov/21318524

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At the interface of the immune system and the nervous system: how neuroinflammation modulates the fate of neural progenitors in vivo

Autor: F J, Mueller, S R, McKercher, J, Imitola, J F, Loring, S, Yip, S J, Khoury, E Y, Snyder

Publikováno v: Ernst Schering Research Foundation workshop. (53)

Neural stem and progenitor cells express a variety of receptors that enable them to sense and react to signals emanating from physiological and pathophysiological conditions in the brain as well as elsewhere in the body. Many of these receptors and w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37a161ca9f42b94469a9d2a122cba3df
https://pubmed.ncbi.nlm.nih.gov/16315610

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A gene expression profile of embryonic stem cells and embryonic stem cell-derived neurons

Autor: J F, Loring, J G, Porter, J, Seilhammer, M R, Kaser, R, Wesselschmidt

Publikováno v: Restorative neurology and neuroscience. 18(2-3)

Embryonic stem (ES) cells have the ability to differentiate into a variety of cell lineages. We are examining ES cell differentiation in vitro by using cDNA microarrays to generate a molecular phenotype for each cell type. El4 ES cells induced by ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ee70652f4d27af5f8a4e0c2caed1451
https://pubmed.ncbi.nlm.nih.gov/11847430

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Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury

Autor: H, Murai, J E, Pierce, R, Raghupathi, D H, Smith, K E, Saatman, J Q, Trojanowski, V M, Lee, J F, Loring, C, Eckman, S, Younkin, T K, McIntosh

Publikováno v: The Journal of comparative neurology. 392(4)

By using transgenic mice that overexpress human beta-amyloid precursor proteins (APPs) at levels twofold higher than endogenous APPs, following introduction of the human APP gene in a yeast artificial chromosome (YAC), we examined the effects of cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1078c29c8e73436b44e3331a07a1b618
https://pubmed.ncbi.nlm.nih.gov/9514508

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