Zobrazeno 1 - 10
of 35
pro vyhledávání: '"J F, Lechner"'
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 259:L262-L269
Normal human bronchial epithelial (NHBE) cells respond to signals initiated by the binding of transforming growth factor-beta type 1 (TGF-beta 1) to its surface receptors by activating pathways that result in terminal squamous differentiation. By use
Autor:
E L, Crawford, G J, Peters, P, Noordhuis, M G, Rots, M, Vondracek, R C, Grafström, K, Lieuallen, G, Lennon, R J, Zahorchak, M J, Georgeson, A, Wali, J F, Lechner, P S, Fan, M B, Kahaleh, S A, Khuder, K A, Warner, D A, Weaver, J C, Willey
Publikováno v:
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology. 6(4)
A method that provides standardized data and is relatively inexpensive and capable of high throughput is a prerequisite to the development of a meaningful gene expression database suitable for conducting multi-institutional clinical studies based on
Publikováno v:
BMC Molecular Biology
Background PCR amplification of target molecules involves sequence specific primers that flank the region to be amplified. While this technique is generally routine, its applicability may not be sufficient to generate a desired target molecule from t
Autor:
R E, Neft, R E, Crowell, F D, Gilliland, M M, Murphy, J L, Lane, H, Harms, T, Coons, E, Heaphy, S A, Belinsky, J F, Lechner
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 7(11)
Lung cancer is the leading cause of cancer-related deaths. The development of sensitive screening methods to identify at-risk individuals before emergence of clinical disease would permit early intervention that could decrease this mortality. Our pre
Autor:
J F, Lechner, R E, Neft, F D, Gilliland, R E, Crowell, D H, Auckley, R T, Temes, S A, Belinsky
Publikováno v:
In vivo (Athens, Greece). 12(1)
Identification of individuals at greatest risk of developing lung cancer could enhance the efficacy of intervention modalities, thereby greatly reducing mortality from this disease. One strategy for identifying these people is to establish molecular
Publikováno v:
Radiation oncology investigations. 5(3)
The objective of the work reviewed herein was to evaluate whether a cancerization field-consisting of cells with genetic alterations can be detected within normal-appearing bronchial epithelium. By using fluorescence in situ hybridization (FISH) for
Autor:
R E, Crowell, F D, Gilliland, R T, Temes, H J, Harms, R E, Neft, E, Heaphy, D H, Auckley, L A, Crooks, S W, Jordan, J M, Samet, J F, Lechner, S A, Belinsky
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 5(8)
Early identification and subsequent intervention are needed to decrease the high mortality rate associated with lung cancer. The examination of bronchial epithelium for genetic changes could be a valuable approach to identify individuals at greatest
Publikováno v:
Radiation research. 145(2)
Inhalation of high-linear energy transfer radiation in the form of radon progeny is a suspected cause of human lung cancer. To gain insight into the types of genetic derangement(s) caused by this type of radiation, lung tumors from beagle dogs expose
Publikováno v:
Cancer research. 54(22)
Other investigators have shown that both sparsely ionizing and UV radiation cause cell cycle arrest that is associated with increased expression of wild-type p53 protein. The effect of exposure to alpha-particles from 238Pu on the induction of the p5
Autor:
R R, Reddel, S E, Salghetti, J C, Willey, Y, Ohnuki, Y, Ke, B I, Gerwin, J F, Lechner, C C, Harris
Publikováno v:
Cancer research. 53(5)
Of five SV40-transformed clonal human bronchial epithelial cell lines previously shown to be nontumorigenic at early passages (R. R. Reddel et al., Cancer Res., 48: 1904-1909, 1988), two lines (BES-1A1 and BEAS-2B) from different donors have become w