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Actions of A-131701, a novel, selective antagonist for alpha-1A compared with alpha-1B adrenoceptors on intraurethral and blood pressure responses in conscious dogs and a pharmacodynamic assessment of in vivo prostatic selectivity

Autor: A A, Hancock, M E, Brune, D G, Witte, K C, Marsh, S, Katwala, I, Milicic, L M, Ireland, D, Crowell, M D, Meyer, J F, Kerwin

Publikováno v: The Journal of pharmacology and experimental therapeutics. 285(2)

A-131701 (3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b, hexahydro-[1H]-benz[e]isoindol-2-yl)ethyl]pyrido [3',4': 4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione) is a novel compound previously shown to be selective for alpha-1a sites compared with alpha-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::824a184a7c7bfae7b8baf3ea42e097b1
https://pubmed.ncbi.nlm.nih.gov/9580607

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Relationships between pharmacokinetics and blockade of agonist-induced prostatic intraurethral pressure and mean arterial pressure in the conscious dog after single and repeated daily oral administration of terazosin

Autor: D G, Witte, M E, Brune, S P, Katwala, I, Milicic, J F, Kerwin, A A, Hancock

Publikováno v: The Journal of pharmacology and experimental therapeutics. 282(2)

The purpose of this study was to determine the potency and selectivity of the alpha-1 adrenergic receptor antagonist terazosin based on relationships between plasma concentrations and blockade of intraurethral pressure (IUP) and mean arterial pressur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9617350997aded144f37fd3d278c4132
https://pubmed.ncbi.nlm.nih.gov/9262356

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Pharmacologic characterization of CHIR 2279, an N-substituted glycine peptoid with high-affinity binding for alpha 1-adrenoceptors

Autor: J A, Gibbons, A A, Hancock, C R, Vitt, S, Knepper, S A, Buckner, M E, Brune, I, Milicic, J F, Kerwin, L S, Richter, E W, Taylor, K L, Spear, R N, Zuckermann, D C, Spellmeyer, R A, Braeckman, W H, Moos

Publikováno v: The Journal of pharmacology and experimental therapeutics. 277(2)

We characterize the in vitro and in vivo pharmacology of CHIR 2279, an N-substituted glycine peptoid previously identified from a combinatorial library as a novel ligand to alpha 1-adrenoceptors. Competitive receptor-binding assays with [3H]prazosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::936153a717dd0e45016b30ac8c330d36
https://pubmed.ncbi.nlm.nih.gov/8627571

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Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro

Autor: A A, Hancock, S A, Buckner, L M, Ireland, S M, Knepper, J F, Kerwin

Publikováno v: Journal of receptor and signal transduction research. 15(7-8)

Terazosin and its enantiomers, antagonists of alpha 1-adrenoceptors, were studied in radioligand binding and functional assays to determine relative potencies at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. The racemic compound and its en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f835a7a6095a91a62b9f5d45ef059aa
https://pubmed.ncbi.nlm.nih.gov/8673721

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Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation

Autor: J. L. Raszkiewicz, D. G. Linville, F. Wagenaar, J. F. Kerwin, S. P. Arneric

Publikováno v: Journal of neuroscience research. 33(1)

This study sought to determine whether the activity of nitric oxide synthase (NOS) is an important physiological link required to mediate increases in cortical cerebral blood flow (CBF) elicited by electrical microstimulation of the basal forebrain (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a30c954d0a90fbf8611be6228aaf7e9
https://pubmed.ncbi.nlm.nih.gov/1280688

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