Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J F, Kachur"'
Autor:
T. Kita, C. E. Smith, K. F. Fok, K. L. Duffin, W. M. Moore, P. J. Karabatsos, J. F. Kachur, F. K. Hamra, N. V. Pidhorodeckyj, L. R. Forte, al. et
Publikováno v:
American Journal of Physiology-Renal Physiology. 266:F342-F348
Guanylin, a peptide homologue of the bacterial heat-stable enterotoxins (ST), is an endogenous activator of guanylate cyclase C (GC-C). We have initiated a search for other members of the guanylin peptide family and in the current study describe a "g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296a3659b5c65bcf186c1e7a33cb5f02
https://doi.org/10.1152/ajprenal.1994.266.2.f342
https://doi.org/10.1152/ajprenal.1994.266.2.f342
Autor:
Lalita Noronha-Blob, W. J. Rzeszotarski, S. G. Farmer, J. F. Kachur, J. P. Carter, T. C. Adams, Carl Kaiser, M. E. Guzewska, Andrea C. Dupont
Publikováno v:
ChemInform. 22
Several dithiane derivatives, prepared as intermediates for compounds structurally related to the therapeutically useful antimuscarinic agent oxybutynin, were effective inhibitors of calcium ion induced contraction of guinea pig ileal strips and of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b835ff70c2032e55bfa9d8e60a816471
https://doi.org/10.1002/chin.199145190
https://doi.org/10.1002/chin.199145190
Autor:
T. C. Adams, M. E. Guzewska, Carl Kaiser, S. G. Farmer, J. P. Carter, Lalita Noronha-Blob, W. J. Rzeszotarski, J. F. Kachur, Andrea C. Dupont
Publikováno v:
Journal of Medicinal Chemistry. 34:1585-1593
Several dithiane derivatives, prepared as intermediates for compounds structurally related to the therapeutically useful antimuscarinic agent oxybutynin, were effective inhibitors of calcium ion induced contraction of guinea pig ileal strips and of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6980a8a5c62b7157a7cfa913e6ce5dad
https://doi.org/10.1021/jm00109a010
https://doi.org/10.1021/jm00109a010
Autor:
Carl Kaiser, D. W. Mcpherson, W. J. Rzeszotarski, Bonnie Sturm, V. H. Audia, M. Abreu, M. Weitzberg, J. F. Kachur
Publikováno v:
Journal of Medicinal Chemistry. 33:307-310
A series of 3-quinuclidinyl atrolactate [3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-2-phenylpropionate, QNA] derivatives in which the methyl group of the parent is substituted with a tertiary amino substituent was prepared and tested for antimuscarinic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a8e241f53605b63e4314ce43885d8d
https://doi.org/10.1021/jm00163a050
https://doi.org/10.1021/jm00163a050
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
Previously, we reported that SC-41930 is a potent leukotriene B4 (LTB4) receptor antagonist. An analog of SC-41930, SC-51146, was evaluated as an antagonist of LTB4 receptors. SC-51146 was shown to bind to LTB4 high affinity binding sites on human ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f2fefdbc32672398f6e901a394e673f
https://pubmed.ncbi.nlm.nih.gov/8138960
https://pubmed.ncbi.nlm.nih.gov/8138960
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(1)
Endothelin-like immunoreactivity has been detected in all regions of the rat gastrointestinal tract. In the present study, we studied the effect of endothelin-1 (ET-1) on muscle contraction and ion transport in the rat colon. Isometric tension was re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27a6ebd6568ddf956092f47a77b3d96e
https://pubmed.ncbi.nlm.nih.gov/1625210
https://pubmed.ncbi.nlm.nih.gov/1625210
Autor:
D, Villani-Price, D C, Yang, R E, Walsh, D J, Fretland, R H, Keith, G, Kocan, J F, Kachur, T S, Gaginella, B S, Tsai
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 260(1)
7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)-propoxy]-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid (SC-41930), a leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity in animal models of colitis, was evaluated for effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e2599020beaa7d953456f6f5e3dc1ee
https://pubmed.ncbi.nlm.nih.gov/1309871
https://pubmed.ncbi.nlm.nih.gov/1309871
Publikováno v:
Gastroenterology. 101(5)
Cholecystokinin (CCK) receptors are currently divided into at least two subtypes: a CCK-A subtype, responsive to the sulfated form of cholecystokinin octapeptide (CCK-8) and selectively antagonized by L-364,718, and a CCK-B subtype, which shares equa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::925192c7cb0c0fdaad9233636a6eb14c
https://pubmed.ncbi.nlm.nih.gov/1936814
https://pubmed.ncbi.nlm.nih.gov/1936814
1. Neurokinin A (NKA) is a mammalian tachykinin distributed principally in the nervous system, including the myenteric innervation of the gut. 2. NKA may be involved in neurogenic inflammation and as a modulatory factor in the diarrhoea associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e7eb0fa26190be4d3ba8cefeca27ba
https://europepmc.org/articles/PMC1180051/
https://europepmc.org/articles/PMC1180051/
Publikováno v:
Biochemical pharmacology. 41(6-7)
Inflammatory phagocytic leukocytes produce superoxide and hydrogen peroxide and secrete myeloperoxidase (MPO) into the extracellular medium. MPO catalyzes the oxidation of Cl- by H2O2 to yield chlorinated oxidants (e.g. HOCl and NH2Cl), which have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c840f61bac09a5ba2660d7b76ef86c4
https://pubmed.ncbi.nlm.nih.gov/1848973
https://pubmed.ncbi.nlm.nih.gov/1848973