Výsledky vyhledávání

Appropriate use of animal models in the assessment of risk during prenatal development: an illustration using inorganic arsenic

Autor: J F, Holson, J M, Desesso, C F, Jacobson, C H, Farr

Publikováno v: Teratology. 62(1)

Assessing risks to human development from chemical exposure typically requires integrating findings from laboratory animal and human studies.Using a case study approach, we present a program designed to assess the risk of the occurrence of malformati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a33a7ba298d583487df3f08723a8bde0
https://pubmed.ncbi.nlm.nih.gov/10861633

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Apparent lability of neural tube closure in laboratory animals and humans

Autor: J M, DeSesso, A R, Scialli, J F, Holson

Publikováno v: American journal of medical genetics. 87(2)

Neural tube defects (NTDs), a set of structural abnormalities affecting the brain, spinal cord, and the skeletal and connective tissues that protect them, are common malformations among humans and laboratory animals. The embryogenesis of the neural t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22cee224d2082d75023aae257033c622
https://pubmed.ncbi.nlm.nih.gov/10533029

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Comparative effects of single intraperitoneal or oral doses of sodium arsenate or arsenic trioxide during in utero development

Autor: D G, Stump, J F, Holson, T L, Fleeman, M D, Nemec, C H, Farr

Publikováno v: Teratology. 60(5)

Numerous studies have suggested that single-day intraperitoneal (IP) injection of inorganic arsenic results in failure of neural tube closure and other malformations in rats, hamsters, and mice. Most of these studies involved treatment of limited num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa4b98c1c1f3e38db9f7862e62108d87
https://pubmed.ncbi.nlm.nih.gov/10525206

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Teratological evaluation of FD&C red no. 2—A collaborative government‐industry study. IV. NCTR's study

Autor: J. F. Holson, H. J. Schumacher, D. W. Gaylor, T. B. Gaines, T. F. X. Collins

Publikováno v: Journal of Toxicology and Environmental Health. 1:867-874

Because of recent studies indicating possible embryolethality and teratogenicity of FDC Red No. 2, an ad hoc committee was convened by the Food and Drug Administration to consider these questions. The committee suggested a collaborative study by thre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97084901bdb4b526ca9d5c0b54842e44
https://doi.org/10.1080/15287397609529388

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Statistical analysis of teratologic data: problems and advancements

Autor: C J, Nelson, J F, Holson

Publikováno v: Journal of environmental pathology and toxicology. 2(1)

A large scale replicated dose-response teratology study of 2,4,5-T was done in mice. Variability and variance of fecundity parameters and fetotoxicity endpoints are discussed. Another study on rats indicated less variation among teratologic endpoints

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c990a05b7756baca0940b5a86765164e
https://pubmed.ncbi.nlm.nih.gov/722220

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Utility of pharmacokinetics in designing toxicological protocols and improving interspecies extrapolation

Autor: J F, Young, J F, Holson

Publikováno v: Journal of environmental pathology and toxicology. 2(1)

Key terms such as pharmacokinetics, pharmacodynamics, time course-concentration, and dosimetry and how they apply to predictive toxicology are defined and differentiated. The importance of utilizing pharmacokinetic techniques in teratology and develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4dc3063d6ae285c3e218f560d842678a
https://pubmed.ncbi.nlm.nih.gov/722219

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Weight differences in rat embryos prior to sexual differentiation

Autor: W J, Scott, J F, Holson

Publikováno v: Journal of embryology and experimental morphology. 40

Sex of day-12 rat embryos was determined using Barr body counts made on spreads of amniotic membranes examined histologically. Embryonic weight, protein content and rate of thymidine incorporation were compared in male and female embryos. Male embryo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::395c4035eb42a0a3acd8ec4b31e14aa3
https://pubmed.ncbi.nlm.nih.gov/915426

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Accuracy of birth certificate data for detecting facial cleft defects in Arkansas children

Autor: H G, Green, C J, Nelson, D W, Gaylor, J F, Holson

Publikováno v: The Cleft palate journal. 16(2)

A comparison of facial cleft defects reported on birth certificates during the period 1943 to 1974 that were reported on birth certificates was made with records maintained by the Arkansas Crippled Childrens Services (CCS). A total of 506 cases were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38a309092afd9b6da40f95514d3795af
https://pubmed.ncbi.nlm.nih.gov/284865

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