Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Autor: Neil Walker, Constantin Ionescu-Tirgoviste, Kathleen M Gillespie, Cristian Guja, David A. Savage, Jane Rogers, Eva Tuomilehto-Wolf, Christopher Patterson, Dag E. Undlien, Laurence B. Peterson, H Ueda, Michael L. Metzker, Francesco Cucca, Jaakko Tuomilehto, C Bordin, R Nithiyananthan, Hywel Snook, Amit Allahabadia, Simon G. Gregory, Helen E. Rance, Jayne A. Franklyn, John A. Todd, A C Lam, F Payne, John S. Hulme, Laura Esposito, Polly J. Bingley, Anne Smith, Giselle Chamberlain, Dennis Carson, Gough Scl., Kjersti S. Rønningen, Deborah J. Smyth, G Di Genova, Barry C. Healy, Alexander P. Maxwell, Joanne M. Heward, Sarah Nutland, Howson Jmm., Christopher E. Lowe, Twells Rcj., Hunter Kmd., Sarah Howlett, Heather J. Cordell, Ingrid Dahlman, J F Hess, David Clayton, Linda S. Wicker, Mathias H. Herr, Vincent H. Everett, Costantino Motzo, Dan Rainbow, Luc J. Smink

Publikováno v: Ueda, H, Howson, J M M, Esposito, L, Heward, J, Snook, H, Chamberlain, G, Rainbow, D B, Hunter, K M D, Smith, A N, Di Genova, G, Herr, M H, Dahlman, I, Payne, F, Smyth, D, Lowe, C, Twells, R C J, Howlett, S, Healy, B, Nutland, S, Rance, H E, Everett, V, Smink, L J, Lam, A C, Cordell, H J, Walker, N M, Bordin, C, Hulme, J, Motzo, C, Cucca, F, Hess, J F, Metzker, M L, Rogers, J, Gregory, S, Allahabadia, A, Nithiyananthan, R, Tuomilehto-Wolf, E, Tuomilehto, J, Bingley, P, Gillespie, K M, Undlien, D E, Ronningen, K S, Guja, C, Ionescu-Tirgoviste, C, Savage, D, Maxwell, A, Carson, D, Patterson, C, Franklyn, J A, Clayton, D G, Peterson, L B, Wicker, L S, Todd, J A & Gough, S C L 2003, ' Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease ' Nature, vol. 423 (6939), no. 6939, pp. 506-511 .

Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)--which enco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4278267511fa630d26092f47f30edae
https://doi.org/10.1038/nature01621

Expression of the Type I Diabetes-associated Gene LRP5 in Macrophages, Vitamin A System Cells, and the Islets of Langerhans Suggests Multiple Potential Roles in Diabetes

Autor: John A. Todd, S D Brown, J F Hess, Rebecca C.J. Twells, D J Figueroa, Bonnie Ky, Christopher P. Austin, V Sandig, A Hermanowski-Vosatka

Publikováno v: Journal of Histochemistry & Cytochemistry. 48:1357-1368

LRP5 is a novel member of the low-density lipoprotein receptor family that is genetically associated with Type 1 diabetes. As a start to defining the normal function of LRP5 and to generate testable hypotheses of its potential role in Type 1 diabetes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f19c57099f984f9986496c467a6eed
https://doi.org/10.1177/002215540004801006

Partial agonists and full antagonists at the human and murine bradykinin B1receptors

Autor: T MacNeil, S Feighner, D L Hreniuk, J F Hess, LHT Van der Ploeg

Publikováno v: Canadian Journal of Physiology and Pharmacology. 75:735-740

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5e2f04a710537af5389f8661089186c
https://doi.org/10.1139/y97-066

Structure and Genomic Organization of the Human B1Receptor Gene for Kinins (BDKRB1)

Autor: J F Hess, Menke Jg, Jean-François Larrivée, Dimcho Bachvarov, François Marceau

Publikováno v: Genomics. 33:374-381

Two subtypes of mammalian bradykinin receptors, B{sub 1} and B{sub 2} (BDKRB1 and BDKRB2), have been defined based on their pharmacological properties. The B{sub 1} type kinin receptors have weak affinity for intact BK or Lys-BK but strong affinity f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807e6106c6835f315018fd755b4f9938
https://doi.org/10.1006/geno.1996.0213

Development- and differentiation-dependent reorganization of intermediate filaments in fiber cells

Autor: T N, Blankenship, J F, Hess, P G, FitzGerald

Publikováno v: Investigative ophthalmologyvisual science. 42(3)

To define the remodeling of lens fiber cell intermediate filaments (IF) that occurs with both development and differentiation.Prenatal and postnatal mice were probed for the IF proteins phakosin, filensin, and vimentin, using light microscope immunoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13153a0d9db6d5f4e6fc1c3f32dbc5ae
https://pubmed.ncbi.nlm.nih.gov/11222535