Výsledky vyhledávání - "J F, Gierthy"

2,2',6,6'-Tetrachlorobiphenyl is estrogenic in vitro and in vivo

Autor: K F, Arcaro, L, Yi, R F, Seegal, D D, Vakharia, Y, Yang, D C, Spink, K, Brosch, J F, Gierthy

Publikováno v: Journal of cellular biochemistry. 72(1)

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose effects on biological systems depend on the number of and the positions of the chlorine substitutions. In the present study we examined the estrogenicity of the fully or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fe0c6eeefa720ff5ac6f47784ad50d3
https://pubmed.ncbi.nlm.nih.gov/10025670

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12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells

Autor: B C, Spink, M J, Fasco, J F, Gierthy, D C, Spink

Publikováno v: Journal of cellular biochemistry. 70(3)

Elevated expression of cytochrome P450 1B1 (CYP1B1) and estradiol 4-hydroxylation have been reported to be biomarkers of tumorigenesis in humans. The aromatic hydrocarbon receptor (AhR) regulates expression of human cytochrome P450 1A1 (CYP1A1) and C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::585f73e4b67b13b4b76a479c01265679
https://pubmed.ncbi.nlm.nih.gov/9706865

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Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Autor: J F, Gierthy, J A, Bennett, L M, Bradley, D S, Cutler

Publikováno v: Cancer research. 53(13)

The purpose of this study was to compare the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the in vitro and in vivo 17 beta-estradiol (E2)-dependent growth of MCF-7 human breast cancer cells. In culture, a major component of postconfluent g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b0e4974b0cb27f6809c539658039c54
https://pubmed.ncbi.nlm.nih.gov/8319224

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Mechanism of regulation of fibroblastic cell replication. IV. An analysis of the serum dependence of cell replication based on Michaelis-Menten kinetics

Autor: J. F. Gierthy, K. A. O. Ellem

Publikováno v: Journal of cellular physiology. 92(3)

The quantitative dependence of the initiation of DNA synthesis in nonreplicating cultures of human diploid fibroblasts (HDFs) on the concentration of fresh serum present in the stimulating medium has been analyzed. A simple formal analysis of the sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e9c4e4667c487bf61ca47291c6f4ed
https://pubmed.ncbi.nlm.nih.gov/903379

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Suppression of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Autor: J F, Gierthy, D W, Lincoln, M B, Gillespie, J I, Seeger, H L, Martinez, H W, Dickerman, S A, Kumar

Publikováno v: Cancer research. 47(23)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) suppresses the estrogen enhancement of tissue plasminogen activator (t-PA) by MCF-7 breast cancer cells. 17 beta-estradiol treatment of MCF-7 cells was previously shown to enhance t-PA secretion in a recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::392bde3a4b86177c875ef39114293088
https://pubmed.ncbi.nlm.nih.gov/3119194

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Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors in Syrian hamsters by prior infection with H-1 parvovirus

Autor: H W, Toolan, S L, Rhode, J F, Gierthy

Publikováno v: Cancer research. 42(7)

Hamsters, given injections s.c. at birth of H-1 parvovirus and 1 month later given a single injection of 7,12-dimethylbenz(a)anthracene, had a 38% tumor incidence compared with a 95% incidence in animals receiving 7,12-dimethylbenz(a)anthracene alone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2d5c7a644141eca8ade39b24524e31c
https://pubmed.ncbi.nlm.nih.gov/6805941

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Loss of metastatic and primary tumor factor X activator capabilities by Lewis lung carcinoma cells cultured in vitamin K-dependent protein deficient serum

Autor: M J, Fasco, G E, Eagan, A C, Wilson, J F, Gierthy, D L, Lincoln

Publikováno v: Cancer research. 48(22)

A highly metastatic line of Lewis lung tumor cells established in fetal bovine serum (10%) was subcultured into normal rodent (mouse or rat) serum or rodent serum made deficient in functional vitamin K-dependent proteins (barium sulfate adsorption or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54449bd8e4efef958020c4819326e5c0
https://pubmed.ncbi.nlm.nih.gov/3180067

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Application of an in vitro keratinization assay to extracts of soot from a fire in a polychlorinated biphenyl-containing transformer

Autor: J F, Gierthy, D, Crane, G D, Frenkel

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 4(6)

A fire in the State Office Building in Binghamton, New York, involving a polychlorinated biphenyl-containing electrical transformer, resulted in contamination of the structure with soot containing 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21cde657fd72a9a88cd99d93390fac08
https://pubmed.ncbi.nlm.nih.gov/6083893

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