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Phase I trial of intratumoral liposome E1A gene therapy in patients with recurrent breast and head and neck cancer

Autor: G H, Yoo, M C, Hung, G, Lopez-Berestein, S, LaFollette, J F, Ensley, M, Carey, E, Batson, T C, Reynolds, J L, Murray

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5)

We conducted a Phase 1 study to determine the maximal tolerated dose and maximum biologically active dose of the E1A gene delivered by intratumoral injection as a lipid complex with 3 beta[N-(n',n'-dimethylaminoethane)-carbamoyl] cholesterol/dioleoyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58f8a3da9af0d8a8d4560637608db633
https://pubmed.ncbi.nlm.nih.gov/11350889

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Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent

Autor: V, Patel, J F, Ensley, J S, Gutkind, W A, Yeudall

Publikováno v: International journal of cancer. 88(5)

We have examined the ability of gamma-irradiation and bleomycin to induce apoptosis in a model system consisting of cell lines derived from naturally occurring human head-and-neck squamous-cell carcinomas with contrasting p53 status and expression le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87790334b57c98c6f543180556e80ac1
https://pubmed.ncbi.nlm.nih.gov/11072242

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Genome-wide analysis of oral cancer--early results from the Cancer Genome Anatomy Project

Autor: E J, Shillitoe, M, May, V, Patel, C, Lethanakul, J F, Ensley, R L, Strausberg, J S, Gutkind

Publikováno v: Oral oncology. 36(1)

The Cancer Genome Anatomy Project (CGAP) is a large cooperative effort sponsored by the US National Institutes of Health designed to find, catalog and annotate genes that are expressed during cancer development. In the past 2 years, the CGAP has sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7e5ed96208788334a85689cb06bdf69
https://pubmed.ncbi.nlm.nih.gov/10889913

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Feasibility trial of postoperative radiotherapy and cisplatin followed by three courses of 5-FU and cisplatin in patients with resected head and neck cancer: a Southwest Oncology Group study

Autor: J A, Kish, J K, Benedetti, S P, Balcerzak, R W, Veith, R, Davis, T W, Pollock, D E, Schuller, J F, Ensley

Publikováno v: The cancer journal from Scientific American. 5(5)

Appropriate adjuvant chemotherapy for resected head and neck cancer patients has yet to be defined. Multiple trials have noted trends toward improved disease-free survival and local control. The Southwest Oncology Group undertook a feasibility trial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77f3096cd776ca482773b01e844e5e43
https://pubmed.ncbi.nlm.nih.gov/10526672

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Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck

Autor: V, Patel, J, Jakus, C M, Harris, J F, Ensley, K C, Robbins, W A, Yeudall

Publikováno v: International journal of cancer. 73(4)

Progressive deregulation of the cell-division cycle is thought to contribute to the establishment and progression of neoplasia. Previously, we have documented the in vivo inactivation of p16INK4A, an inhibitor of G1 cyclin-dependent kinases, in squam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ca926507ef993747c10ff10c76dbd59
https://pubmed.ncbi.nlm.nih.gov/9389571

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Functional characterization in vivo of mutant p53 molecules derived from squamous cell carcinomas of the head and neck

Autor: M, Cardinali, F J, Kratochvil, J F, Ensley, K C, Robbins, W A, Yeudall

Publikováno v: Molecular carcinogenesis. 18(2)

Loss of wild-type p53, either through deletion or mutation, has been demonstrated in most squamous cell carcinomas of the head and neck (HNSCC). Whether these mutant molecules contribute to tumor progression purely through loss of wild-type functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1463fa974787dce91b722acd1cb563f
https://pubmed.ncbi.nlm.nih.gov/9049183

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Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck

Autor: W A, Yeudall, J, Jakus, J F, Ensley, K C, Robbins

Publikováno v: Molecular carcinogenesis. 18(2)

Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee4d41eb344b4410a2429185a8ca7300
https://pubmed.ncbi.nlm.nih.gov/9049184

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