Zobrazeno 1 - 8
of 8
pro vyhledávání: '"J F, DiJoseph"'
Publikováno v:
Transplantation proceedings. 25(1 Pt 1)
Autor:
L E, Borella, J F, DiJoseph
Publikováno v:
Arzneimittel-Forschung. 39(5)
AY-28,200 (2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester), a new gastric antisecretory/antiulcer agent, inhibited basal and pentagastrin-stimulated gastric acid secretion in the conscious rat (ED50 = 7.6 and 1.9 mg/kg i.g., respect
Publikováno v:
Arzneimittel-Forschung. 39(7)
The cytoprotective and antiulcer activities of the antacid magaldrate (ES Riopan) as well as its effects on gastric mucosal blood flow and mucus secretions, were determined in the rat. Magaldrate afforded protection against gastric necrotic lesions i
Autor:
J. F. DiJoseph, C. L. Wells
Publikováno v:
Agents and actions. 27(3-4)
Epidermal growth factor (EGF, 10 micrograms/kg po, ip, or sc, BID, and 20 micrograms/kg iv) had no protective activity in the indomethacin-induced intestinal lesion model (6 h model). In the ethanol-induced gastric lesion model, EGF (10 micrograms/kg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 241(1)
The gastric antisecretory and antiulcer effects of a novel compound, [1-(2,-dimethylphenyl)-3-isobutoxyamidinourea]hydrochloride (WHR1582A), are described. WHR1582A was active in preclinical ulcer models induced by 18-hr pylorus ligation, aspirin, in
Publikováno v:
Life sciences. 35(10)
Alpha-2 receptor activation mediates the inhibition of a number of gastrointestinal functions including gastric and intestinal secretions. Alpha-2 receptors are located in the brain and presynaptically on cholinergic nerve terminals; activation of ei
Autor:
J F, DiJoseph, G N, Mir
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 288(2)
Lidamidine, a new antidiarrheal agent, produced a dose-dependent increase in plasma glucose levels in fed rats. The hyperglycemic response was evident 10 min after oral administration of lidamidine and lasted for 4 hr. Lidamidine's effect was absent
Publikováno v:
Gastroenterology. 96(3)
Removing the buffering capacity of aluminum-containing antacids by acidification greatly increased their cytoprotective activity over the parent antacid. Commercially available antacids were acidified with 6 N HCl. Peak mucosal protective activity oc