The impact of EU public procurement regulations on tenders in Spain: a study with adalimumab

Autor: F. J. Esplugues, I. Andújar, J. V. Esplugues

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

IntroductionPharmaceutical spending accounts for a significant portion of public healthcare budgets. To manage these costs, EU countries implement various cost-containment policies, including competitive tendering for pharmaceuticals. This study exam

Externí odkaz: https://doaj.org/article/1ae03e635b574101b039e4d3a9c5a1de

Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells

Autor: Pablo Martí-Rodrigo, Francisco García-García, Nadezda Apostolova, Alberto Martí-Rodrigo, Fernando Alegre, Jordi Gracia-Sancho, J Esplugues, Ángela B. Moragrega, Anabel Fernández-Iglesias, Ana Blas-Garcia

Publikováno v: GUT
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Gut
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)

ObjectiveLiver fibrosis constitutes a major health problem worldwide due to its rapidly increasing prevalence and the lack of specific and effective treatments. Growing evidence suggests that signalling through cytokine-activated Janus kinase (JAK)-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e45db381e4642518af33d338fa33a
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3659

Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress

Autor: J Esplugues, Ana Blas-Garcia, Nadezda Apostolova, Alberto Martí-Rodrigo, Lara Gibellini, Miriam Polo, Fernando Alegre, Ángela B. Moragrega

Publikováno v: British Journal of Pharmacology. 174:4409-4429

Background and Purpose Mitochondria-associated membranes (MAMs) are specific endoplasmic reticulum (ER) domains that enable it to interact directly with mitochondria and mediate metabolic flow and Ca2+ transfer. A growing list of proteins have been i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22707267d19747256f1f70094925fe7e
https://doi.org/10.1111/bph.14045

A pharmacological study ofAraujia sericifera B. extracts in rodents

Autor: R. Bello, J. Esplugues, E. Primo Yúfera, M. J. Lopez De Medrano-Villar, C. Borges, Juan V. Esplugues

Publikováno v: Phytotherapy Research. 9:128-134

The present study analyses the pharmacological activity in in vitro and in vivo models of different extracts obtained from Araujia sericifera. The hexane extract of fruits lacked toxicity, but exhibited an analgesic effect in models of chemical and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c85f57c05aecc5926ba8e6414c376f02
https://doi.org/10.1002/ptr.2650090210

Cardiovascular effects of the methanol and dichloromethanol extracts from Mentha suaveolens Ehrh

Autor: R, Bello, S, Calatayud, B, Beltrán, E, Primo-Yúfera, J, Esplugues

Publikováno v: PHYTOTHERAPY RESEARCH
r-FISABIO. Repositorio Institucional de Producción Científica
instname

Methanol and dichloromethanol extracts of the leaves and stems of Mentha suaveolens Ehrh. have been tested for their effects on resting arterial blood pressure, heart rate and noradrenaline induced hypertension. Both extracts administered by i.v. bol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a9544f45c39933e07b12dec943677053
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=10507