Výsledky vyhledávání

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

Autor: Stuart W. J. Ember, Camilla T. O. Benfield, Michela Mazzon, Geoffrey L. Smith, Brian J. Ferguson, Carlos Maluquer de Motes, Rebecca P. Sumner

Publikováno v: Journal of General Virology. 94:2367-2392

Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity. In response, viruses have evolved many countermeasures that enable th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71a51c0988dc1cdbad141e3c494e49b
https://doi.org/10.1099/vir.0.055921-0

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Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence

Autor: Geoffrey L. Smith, Brian J. Ferguson, Stuart W. J. Ember, Hongwei Ren

Publikováno v: The Journal of General Virology

Vaccinia virus (VACV) strain Western Reserve protein C4 has been characterized and its function and contribution to virus virulence assessed. Bioinformatic analysis showed that C4 is conserved in six orthopoxvirus species and shares 43 % amino acid i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb829239bfca4378c05211aa4677ec3f
http://europepmc.org/articles/PMC3541790

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Peptide-tags for enhanced DNA microarray performance

Autor: Ilenia Ciani, Till T. Bachmann, Anthony J. Walton, Mizanur Khondoker, Jonathan G. Terry, Alan J. Ross, Jason Crain, Peter Ghazal, Gerard Giraud, Colin Campbell, Holger Schulze, Julie Luby, Andrew R. Mount, Stuart W. J. Ember, Davide Papale, Chaker Tlili

Publikováno v: Schulze, H, Ross, A J, Ember, S W J, Luby, J, Khondoker, M, Giraud, G, Ciani, I, Tlili, C, Papale, D, Terry, J G, Mount, A R, Walton, A J, Crain, J, Ghazal, P, Bachmann, T T & Campbell, C J 2011, ' Peptide-tags for enhanced DNA microarray performance ', Faraday Discussions, vol. 149, pp. 201-210 . https://doi.org/10.1039/c005491g

DNA microarrays are powerful tools for gene expression analysis and genotyping studies in research and diagnostic applications. A high sensitivity and short time-to-result are prerequisites for their practical application in the clinic. The hybridiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73546a11e6333e5bd0403640e1d79413
https://doi.org/10.1039/c005491g

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MULTI-FACTORIAL ANALYSIS OF CLASS PREDICTION ERROR: ESTIMATING OPTIMAL NUMBER OF BIOMARKERS FOR VARIOUS CLASSIFICATION RULES

Autor: Andrews R. Mount, Bartosz Dobrzelecki, Anthony J. Walton, Paul Dickinson, Peter Ghazal, Alan J. Ross, Jason Crain, Mizanur Khondoker, Chaker Tlili, Eilidh Grant, Stuart W. J. Ember, Jonathan G. Terry, Nicola McDonnell, Gerard Giraud, Ilenia Ciani, Colin Campbell, Holger Schulze, Muries Mewissen, Till T. Bachmann

Publikováno v: Journal of Bioinformatics and Computational Biology. :945-965

Machine learning and statistical model based classifiers have increasingly been used with more complex and high dimensional biological data obtained from high-throughput technologies. Understanding the impact of various factors associated with large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422e897c8878ae26b0a55db8122bebbf
https://doi.org/10.1142/s0219720010005063

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Solution state hybridization detection using time-resolved fluorescence anisotropy of quantum dot-DNA bioconjugates

Autor: Peter Ghazal, Mizanur Khondoker, Till T. Bachmann, Holger Schulze, Chaker Tlili, Jonathan G. Terry, Jason Crain, Colin Campbell, Ilenia Ciani, Andrew R. Mount, Gerard Giraud, Anthony J. Walton, Stuart W. J. Ember

Publikováno v: Chemical Physics Letters. 484:309-314

In this Letter, we demonstrate the application of time-resolved fluorescence anisotropy measurements to detect solution state hybridization of streptavidin conjugate (CdSe)ZnS quantum dots (QD). The study was performed on samples containing 10 nM QD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::329b1479099f651970a4749ef787780e
https://doi.org/10.1016/j.cplett.2009.11.032

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Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Autor: Stephan C. Schürer, Saurabh Mehta, Nagi G. Ayad, Stewart W. J. Ember, Bryce K. Allen, Ernst Schönbrunn

Publikováno v: Scientific Reports

Inhibition of cancer-promoting kinases is an established therapeutic strategy for the treatment of many cancers, although resistance to kinase inhibitors is common. One way to overcome resistance is to target orthogonal cancer-promoting pathways. Bro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210598b37f5fb1715ea8d2d268bb437f
https://doi.org/10.1038/srep16924

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Fast DNA and protein microarray tests for the diagnosis of hepatitis C virus infection on a single platform

Autor: Julie Luby, Chaker Tlili, Mizanur Khondoker, Jason Crain, Peter Ghazal, Alan J. Ross, Gerard Giraud, Andrew R. Mount, Stuart W. J. Ember, Holger Schulze, Jonathan G. Terry, Colin Campbell, Till T. Bachmann, Ilenia Ciani, Anthony J. Walton

Publikováno v: Ember, S W J, Schulze, H, Ross, A J, Luby, J, Khondoker, M, Giraud, G, Terry, J G, Ciani, I, Tlili, C, Crain, J, Walton, A J, Mount, A R, Ghazal, P, Bachmann, T T & Campbell, C J 2011, ' Fast DNA and protein microarray tests for the diagnosis of hepatitis C virus infection on a single platform ', Analytical and bioanalytical chemistry, vol. 401, no. 8, pp. 2549-2559 . https://doi.org/10.1007/s00216-011-5332-5

Hepatitis C virus (HCV) is a major cause of chronic liver disease and liver cancer, and remains a large health care burden to the world. In this study we developed a DNA microarray test to detect HCV RNA and a protein microarray to detect human anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6011a8475ee80da80fc4d68c90628f55
https://pubmed.ncbi.nlm.nih.gov/21881881

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Fluorescence Lifetime Imaging of Quantum Dot Labeled DNA Microarrays

Autor: Mizanur Khondoker, Andrew R. Mount, Alan J. Ross, Peter Ghazal, Jason Crain, Holger Schulze, Till T. Bachmann, Anthony J. Walton, Chaker Tlili, Ilenia Ciani, Gerard Giraud, Colin Campbell, Jonathan G. Terry, Stuart W. J. Ember

Publikováno v: Giraud, G, Schulze, H, Bachmann, T T, Campbell, C J, Mount, A R, Ghazal, P, Khondoker, M R, Ross, A J, Ember, S W J, Ciani, I, Tlili, C, Walton, A J, Terry, J G & Crain, J 2009, ' Fluorescence Lifetime Imaging of Quantum Dot Labeled DNA Microarrays ', International Journal of Molecular Sciences, vol. 10, no. 4, pp. 1930-1941 . https://doi.org/10.3390/ijms10041930
International Journal of Molecular Sciences, Vol 10, Iss 4, Pp 1930-1941 (2009)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 10; Issue 4; Pages: 1930-1941

Quantum dot (QD) labeling combined with fluorescence lifetime imaging\ud microscopy is proposed as a powerful transduction technique for the detection of DNA\ud hybridization events. Fluorescence lifetime analysis of DNA microarray spots of\ud hybrid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f664110c3d1c4ae3d0fe819c73b428
https://hdl.handle.net/20.500.11820/c421cb4d-c288-4735-8c8f-281ec28d38b5

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