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A Biochemical and Functional Assessment of Monocyte Phosphodiesterase Activity in Healthy and Asthmatic Subjects

Autor: Brian J. O'Connor, Clive P. Page, Domenico Spina, L J Landells, J E Souness

Publikováno v: Pulmonary Pharmacology & Therapeutics. 13:231-239

The aim of this study was to investigate whether cyclic adenosine 3'5-monophosphate (cAMP) phosphodiesterase (PDE) activity is altered in monocytes from mild asthmatic subjects. Total cAMP PDE activity (pmol/min per mg protein) was significantly grea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a773dab7803f5a25eea0dad9a85c1ce
https://doi.org/10.1006/pupt.2000.0248

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Potential of phosphodiesterase type of IV inhibitors in the treatment of rheumatoid arthritis

Autor: J E, Souness, M, Foster

Publikováno v: IDrugs : the investigational drugs journal. 1(5)

Rheumatoid arthritis (RA) is a crippling autoimmune disease which afflicts over 1% of the population. Non-steroidal anti-inflammatory drugs are widely used palliatives, but these disease-modifying drugs are of variable and limited efficacy, and are f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bda1812fa82b3f6c6060da3af21a9a7
https://pubmed.ncbi.nlm.nih.gov/18465594

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Potential of p38 inhibitors in the treatment of rheumatoid arthritis

Autor: M L, Foster, F, Halley, J E, Souness

Publikováno v: Drug newsperspectives. 13(8)

Rheumatoid arthritis (RA) is a chronic debilitating disease estimated to afflict 13% of the world population. Although palliative treatments (nonsteroidal antiinflammatory drugs or NSAIDs) are widely prescribed, there are currently only a few treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d6cb51a24679951ab0d2df5f795f419
https://pubmed.ncbi.nlm.nih.gov/12937622

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Phosphodiesterase type IV inhibitors

Autor: M N, Palfreyman, J E, Souness

Publikováno v: Progress in medicinal chemistry. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65cda32ab243a0d762f4e101e27539a3
https://pubmed.ncbi.nlm.nih.gov/8776940

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Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase

Autor: J E Souness, L C Scott

Publikováno v: The Biochemical journal. 291

The stereospecificity of rolipram inhibition of particulate cyclic AMP-specific phosphodiesterase (PDE IV) from guinea-pig eosinophils has been investigated. (-)-Rolipram (IC50 = 0.22 +/- 0.08 microM) was 2.5-fold more potent than (+)-rolipram (IC50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76c9afab05a5abeec84d844f771b690
https://pubmed.ncbi.nlm.nih.gov/8387267

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Isozyme-selective cyclic nucleotide phosphodiesterase inhibitors: biochemistry, pharmacology and therapeutic potential in asthma

Autor: D, Raeburn, J E, Souness, A, Tomkinson, J A, Karlsson

Publikováno v: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d00366395dcd279ec2112add663b4a3
https://pubmed.ncbi.nlm.nih.gov/8395068

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Characterization of guinea-pig eosinophil phosphodiesterase activity. Assessment of its involvement in regulating superoxide generation

Autor: J E, Souness, C M, Carter, B K, Diocee, G A, Hassall, L J, Wood, N C, Turner

Publikováno v: Biochemical pharmacology. 42(4)

Experiments have been performed to characterize guinea-pig peritoneal eosinophil cyclic nucleotide phosphodiesterase (PDE) activity and establish whether it is involved in regulating superoxide (.O2-) generation. Eosinophils were found to contain a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85399545b0a4e8605d6de0d5365bad5b
https://pubmed.ncbi.nlm.nih.gov/1651083

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Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells

Autor: B K Diocee, J E Souness, S A Moodie, W Martin

Publikováno v: The Biochemical journal. 266(1)

Two cyclic nucleotide phosphodiesterase (PDE) activities were identified in pig aortic endothelial cells, a cyclic GMP-stimulated PDE and a cyclic AMP PDE. Cyclic GMP-stimulated PDE had Km values of 367 microM for cyclic AMP and 24 microM for cyclic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de5adccda73930e0e39b94cc017024e
https://pubmed.ncbi.nlm.nih.gov/2155604

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Effect of N6-methyladenosine on fat-cell glucose metabolism. Evidence for two modes of action

Autor: J E, Souness, J E, Stouffer, V, Chagoya de Sanchez

Publikováno v: Biochemical pharmacology. 31(24)

N6-Methyladenosine strongly stimulates [1-14C]glucose oxidation in rat adipocytes [J.E. Souness and V. Chagoya de Sanchez, Fedn Eur. Biochem. Soc. Lett. 125, 249 (1981)]. The effect of the adenosine analogue is largely independent of its action as an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b641acf7dbbbc3b78c05cec1dee6ac0c
https://pubmed.ncbi.nlm.nih.gov/6297505

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