Zobrazeno 1 - 10 of 15 pro vyhledávání: '"J E Shellito"'
2
Effect of alcohol consumption on host release of interleukin-17 during pulmonary infection with Klebsiella pneumoniae
Autor: J E, Shellito, M, quan Zheng, P, Ye, S, Ruan, M K, Shean, J, Kolls
Publikováno v: Alcoholism, clinical and experimental research. 25(6)
A link between alcohol abuse and bacterial pneumonia has been recognized for centuries, but mechanisms to explain this relationship are unclarified. Interleukin-17 (IL-17) is a lymphocyte-derived cytokine that is part of the inflammatory cytokine cas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1186af156d81af33b3d5c3c1b610d948
https://pubmed.ncbi.nlm.nih.gov/11410724
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3
Gene therapy to modify pulmonary host defenses
Autor: J K, Kolls, P, Ye, J E, Shellito
Publikováno v: Seminars in respiratory infections. 16(1)
Respiratory infections remain a significant public health problem and are presently the 6th leading cause of death in the United States. Antibiotic-resistant organisms are encountered increasingly in both community-acquired and nosocomial infections.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f13c7e0ff44e3ee7ec47cb82992db188
https://pubmed.ncbi.nlm.nih.gov/11309709
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4
Orthotopic human lung carcinoma xenografts in BALB/c mice immunosuppressed with anti-CD4 monoclonal antibodies and chronic alcohol consumption
Autor: J D, Hunt, E G, Robert, A W, Zieske, A P, Bautista, M, Bukara, D, Lei, J E, Shellito, S, Nelson, J K, Kolls, N, Skrepnik
Publikováno v: Cancer. 88(2)
The role of the immune system in the surveillance of the body for cancer cells is well established. Human tumor cells do not survive in mice with intact immune systems, but they propagate in athymic nude mice. Presumably, the lack of a thymus gland a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::497c48b4b4d41700e559fabb028a2fd8
https://pubmed.ncbi.nlm.nih.gov/10640982
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5
IFN-gamma and CD8+ T cells restore host defenses against Pneumocystis carinii in mice depleted of CD4+ T cells
Autor: J K, Kolls, S, Habetz, M K, Shean, C, Vazquez, J A, Brown, D, Lei, P, Schwarzenberger, P, Ye, S, Nelson, W R, Summer, J E, Shellito
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(5)
Host defenses against infection are profoundly compromised in HIV-infected hosts due to progressive depletion of CD4+ T lymphocytes and defective cell-mediated immunity. Although recent advances in antiretroviral therapy can dramatically lower HIV vi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90444dd42af91ce2b0030759ffcdd322
https://pubmed.ncbi.nlm.nih.gov/10072538
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6
The human immunodeficiency virus type I Tat protein potentiates ethanol-induced neutrophil functional impairment in transgenic mice
Autor: O, Prakash, P, Zhang, M, Xie, M, Ali, P, Zhou, R, Coleman, D A, Stoltz, G J, Bagby, J E, Shellito, S, Nelson
Publikováno v: Alcoholism, clinical and experimental research. 22(9)
Neutropenia and impairment of neutrophil function are commonly observed in patients with human immunodeficiency virus (HIV) infections. The HIV regulatory protein Tat is known to exert immunosuppressive effects. Alcohol is known also to be an immunos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::750622c53cf2168048e3417ee3662aee
https://pubmed.ncbi.nlm.nih.gov/9884149
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7
Adenoviral-mediated interferon-gamma gene therapy augments pulmonary host defense of ethanol-treated rats
Autor: J K, Kolls, D, Lei, D, Stoltz, P, Zhang, P O, Schwarzenberger, P, Ye, G, Bagby, W R, Summer, J E, Shellito, S, Nelson
Publikováno v: Alcoholism, clinical and experimental research. 22(1)
Alcohol has long been recognized as an immunosuppressive drug and a risk factor for a spectrum of infectious diseases. Among these infections, bacterial pneumonias are most closely correlated with alcohol abuse. One potential mechanism of ethanol-ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5fbc45d65186e321cd0785fe6bf746d5
https://pubmed.ncbi.nlm.nih.gov/9514301
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9
CD4+ T lymphocyte depletion attenuates lipopolysaccharide-induced tumor necrosis factor secretion by alveolar macrophages in the mouse
Autor: N B, D'Souza, F J, Mandujano, S, Nelson, W R, Summer, J E, Shellito
Publikováno v: Lymphokine and cytokine research. 13(6)
Mechanisms underlying the control of cytokine secretion by alveolar macrophages are not fully understood. We hypothesized that T lymphocytes or their products modulate the capacity of alveolar macrophages to release cytokines in response to an exogen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c83fd490f40c662b74bdf884760bd2c0
https://pubmed.ncbi.nlm.nih.gov/7703309
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10
Immunomodulatory and toxic effects of free and liposome-encapsulated tumor necrosis factor alpha in rats
Autor: R J, Debs, H J, Fuchs, R, Philip, E N, Brunette, N, Düzgüneş, J E, Shellito, D, Liggitt, J R, Patton
Publikováno v: Cancer research. 50(2)
Tumor necrosis factor alpha has potent immunomodulatory and antitumor activity, but its therapeutic applications may be limited by its significant host toxicity. We showed that liposome-encapsulated recombinant human tumor necrosis factor alpha (rHuT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8e0c67d59bd82e06e44862526201407
https://pubmed.ncbi.nlm.nih.gov/2295077
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