Výsledky vyhledávání - "J E Schweinle"

Surges of advanced medical support associated with influenza outbreaks

Autor: Y. Gao, J. E. Schweinle, R. J. Hatchett, James A Zhou, Richard Lichenstein, James C King

Publikováno v: Epidemiol Infect

SUMMARYWe utilized de-identified data to evaluate increases in four outcomes during influenza outbreak periods (IOPs) including: hospitalization, intensive care unit admission, mechanical ventilation or death for adults aged 18 years or older with me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f042758dfcab1a9619b154e9f930354
https://doi.org/10.1017/s095026881700111x

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Truncated forms of mannose-binding protein multimerize and bind to mannose-rich Salmonella montevideo but fail to activate complement in vitro

Autor: K. Sastry, Tie Qiang Ding, S. D. Gillies, J. E. Schweinle, R. A. B. Ezekowitz, M. Nishiyasu

Publikováno v: Journal of Biological Chemistry. 268:364-370

Human serum (MBP) and human recombinant (rMBP) mannose-binding protein bind to mannose-rich, serum-resistant Salmonella montevideo (SH5770), enhance C3 deposition, and render the organisms serum-sensitive. We investigated structural features of MBP n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ccb4519b314107f31ce7ea7b547806d
https://doi.org/10.1016/s0021-9258(18)54159-4

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Distinct and overlapping functions of allelic forms of human mannose binding protein

Autor: Kedarnath N. Sastry, J. E. Schweinle, V. J. Silverman, Michael Super, R. A. B. Ezekowitz, S. Foley, S. D. Gillies

Publikováno v: Nature Genetics. 2:50-55

Human mannose binding protein (MBP) is a C-type serum lectin involved in first-line host defense against a variety of bacterial, fungal and viral pathogens. Recently an association was found between low levels of serum MBP and an increased frequency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf2f9ea6d5669e99f658b445fcab497
https://doi.org/10.1038/ng0992-50

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Sub-minimal inhibitory concentrations of cefmetazole enhance serum bactericidal activity in vitro by amplifying poly-C9 deposition

Autor: M Nishiyasu, J E Schweinle

Publikováno v: Journal of Clinical Investigation. 89:1198-1207

Serum-resistant organisms grown in sub-minimal inhibitory concentrations (subMICs) of antibiotics in vitro may be rendered sensitive to complement-mediated, serum bactericidal activity. We measured 125I-C3 and 125I-C9 deposition on genetically serum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3842df43914867ecad52b7161899ebf4
https://doi.org/10.1172/jci115703

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Modulation of mouse complement receptors 1 and 2 suppresses antibody responses in vivo

Autor: G Thyphronitis, T Kinoshita, K Inoue, J E Schweinle, G C Tsokos, E S Metcalf, F D Finkelman, J E Balow

Publikováno v: The Journal of Immunology. 147:224-230

A mAb, 7G6, that binds to mouse CR1 and CR2 and down-modulates their expression on splenic B cells in vivo, was used to determine whether a decrease in CR1 and CR2 expression affects antibody responses to different T-dependent and T-independent Ag. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18ab1e857e71825fabcea19acb3913a1
https://doi.org/10.4049/jimmunol.147.1.224

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Cost associated with the treatment of influenza in a managed care setting

Autor: F, Cox, Z M, Khan, J E, Schweinle, L, Okamoto, T, McLaughlin

Publikováno v: MedGenMed : Medscape general medicine. 2(4)

The purpose of this study was to assess the costs and treatments associated with influenza patients with and without secondary viral or bacterial infections in a managed care setting.Patients with influenza diagnoses (ICD-9 = 487) were identified in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::444ef69325943a74a86a9945d78500d6
https://pubmed.ncbi.nlm.nih.gov/11104480

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Truncated forms of mannose-binding protein multimerize and bind to mannose-rich Salmonella montevideo but fail to activate complement in vitro

Autor: J E, Schweinle, M, Nishiyasu, T Q, Ding, K, Sastry, S D, Gillies, R A, Ezekowitz

Publikováno v: The Journal of biological chemistry. 268(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23e79c515cfc6c94a6b44bdd0f36b3f7
https://pubmed.ncbi.nlm.nih.gov/8416944

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Pneumococcal intracellular killing is abolished by polysaccharide despite serum complement activity

Autor: J E Schweinle

Publikováno v: Infection and Immunity. 54:876-881

Normal human serum absorbed at 0 degrees C with pneumococcal serotype 1, 12, or 25 lost the ability to support polymorphonuclear leukocyte intracellular killing of some pneumococcal serotypes even if immunoglobulin was provided. The absorbed serum co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46ba51e6cb5e8c2b0e30f7dc8e30a1e
https://doi.org/10.1128/iai.54.3.876-881.1986

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Human mannose-binding protein activates the alternative complement pathway and enhances serum bactericidal activity on a mannose-rich isolate of Salmonella

Autor: Keith A. Joiner, M. Kuhlman, Andrea J. Tenner, R. A. B. Ezekowitz, J. E. Schweinle

Publikováno v: Scopus-Elsevier

The human mannose-binding protein (MBP) is a multimeric serum protein that is divided into three domains, a cysteine-rich NH2-terminal domain that stabilizes the collagen alpha helix of the second domain and a third COOH-terminal carbohydrate recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606112ea03111fbe1b13a5726c3c8561
https://doi.org/10.1172/jci114367

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Halogenation and proteolysis of complement component C3 on Salmonella typhimurium during phagocytosis by human neutrophils

Autor: K A Joiner, J E Schweinle

Publikováno v: The Journal of Immunology. 142:3164-3170

We examined the fate of C component C3 on the surface of Salmonella typhimurium during ingestion by human neutrophils. Initial experiments showed that C3 fragments and C3-acceptor complexes were the major serum ligands which were surface iodinated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58bae6bc242e391428c40ba7c955cb5f
https://doi.org/10.4049/jimmunol.142.9.3164

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