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pro vyhledávání: '"J E Mrochek"'
This document attempts to reconstruct the role played by the Chemical Technology Division (Chem Tech) of the Oak Ridge National Laboratory (ORNL) in the atomic era since the 1940`s related to the development and production of nuclear weapons and powe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c0b279369f595c116f829a830a1f48d
https://doi.org/10.2172/10122219
https://doi.org/10.2172/10122219
Publikováno v:
Clinical Chemistry. 22:1821-1827
The identification of nicotinamide-N1-oxide as a metabolite in the urine of a schizophrenic patient prompted a study of the relative metabolism of nicotinic acid and nicotinamide in mental patients and healthy volunteers. Metabolites quantified inclu
Publikováno v:
Clinical Chemistry. 20:1086-1096
Acetaminophen is a commonly used analgesic, available without prescription. Several of its metabolites have heretofore been isolated from physiologic fluids and analytically characterized. In general, the separation methods are complicated, usually r
Publikováno v:
Clinical Chemistry. 27:1516-1523
The metabolism of the synthetic substrate 7-ethoxyresorufin is a selective measure of the activity of cytochrome P-448 monooxygenase, the subset of cytochrome P-450-mediated enzymes preferentially induced by polycyclic aromatic hydrocarbons and relat
Publikováno v:
Analytical Chemistry. 53:1154-1159
Response surface methodology (RSM) offers the analytical chemist a statistically sound, efficient, and effective means for developing, evaluating, and optimizing analytical methods. To assist in processing the analytical workload generated by RSM, we
Autor:
J E Mrochek, W D Bostick
Publikováno v:
Clinical Chemistry. 23:1633-1639
The differential activation method for the determination of the "myocardial" isoenzyme of creatine kinase (MB) is based on the computed difference in activity of serum aliquots activated by the combination of dithiothreitol and glutathione (skeletal
Autor:
Charles D. Scott, J E Mrochek, D G Lakomy, W. F. Johnson, R K Genung, M L Bauer, Carl A. Burtis
Publikováno v:
Clinical Chemistry. 23:1416-1426
Developments in solid-state electronics have resulted in the fabrication of a prototype portable instrument with expanded analytical versatility and the capability to operate from 110 V ac or a rechargeable battery pack. The analyzer, contained in an
Autor:
J. E. Mrochek, W. T. Rainey
Publikováno v:
Clinical Chemistry. 18:821-828
The normal urinary chromatographic pattern on the high-resolution UV-Analyzer exhibits approximately 20 major peaks and more than 100 minor peaks. Three of the major chromatographic peaks, observed in most urinary samples from both normal and patholo
Autor:
J. E. Mrochek, D. D. Chilcote
Publikováno v:
Clinical Chemistry. 18:778-782
A chromatographic separation system has been developed for determination of various indole derivatives in physiologic fluids. A coupled-column configuration is used in which a 0.22 x 25 cm, jacketed, stainless-steel anion-exchange column is connected
Publikováno v:
Clinical Chemistry. 17:72-77
High-pressure anion-exchange chromatography with gradient elution has been used to resolve ultraviolet-absorbing constituents from normal and pathologic specimens of human urine. We have identified 50 of these constituents by using multiple-analytica