Zobrazeno 1 - 10
of 113
pro vyhledávání: '"J E Ingram"'
Publikováno v:
Advanced Dairy Chemistry ISBN: 9783030925840
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac542f44b8cf8fedbe917a180e5d284
https://doi.org/10.1007/978-3-030-92585-7_6
https://doi.org/10.1007/978-3-030-92585-7_6
Publikováno v:
The pharmacogenomics journal. 21(1)
Inter-individual variation of drug metabolising enzymes (DMEs) leads to variable efficacy of many drugs and even adverse drug responses. Consequently, it would be desirable to test variants of many DMEs before drug treatment. Inter-ethnic differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1983ddfc6ade75e28cbaa9a72a4b672
https://pubmed.ncbi.nlm.nih.gov/32683419
https://pubmed.ncbi.nlm.nih.gov/32683419
Autor:
Michael Sendtner, Christopher A Plaster, Michael E. Weale, Elizabeth M. C. Fisher, Karen E. Morrison, Marcus Beck, Neil Bradman, Hardev Pall, Catherine J. E. Ingram, Emily F. Goodall, Dalia Kasperavičiūtė, Sibylle Jablonka
Publikováno v:
Amyotrophic Lateral Sclerosis. 13:341-346
While some cases of familial ALS can be entirely attributed to known inherited variation, the majority (∼ 90%) are sporadic, where the cause(s) are not entirely understood. Both genetic and environmental factors may contribute to susceptibility. Mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b554e11e401a58324f40cdf64ab3ee
https://doi.org/10.3109/17482968.2012.654394
https://doi.org/10.3109/17482968.2012.654394
Autor:
Dallas M. Swallow, Mark G. Thomas, Sarah L. Browning, Endashaw Bekele, Neil Bradman, Catherine J. E. Ingram, Tamiru Oljira Raga, Mohamed F. Elamin, Michael E. Weale, Ayele Tarekegn
Publikováno v:
Journal of Molecular Evolution. 69:579-588
Persistence of intestinal lactase into adulthood allows humans to use milk from other mammals as a source of food and water. This genetic trait has arisen by convergent evolution and the derived alleles of at least three different single nucleotide p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f874b1dbb89388b6f7c663c3a44c60
https://doi.org/10.1007/s00239-009-9301-y
https://doi.org/10.1007/s00239-009-9301-y
Publikováno v:
Human Genetics. 124:579-591
It has been known for some 40 years that lactase production persists into adult life in some people but not in others. However, the mechanism and evolutionary significance of this variation have proved more elusive, and continue to excite the interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad97735b9fd9cca34a6d41cd2f7e5c2
https://doi.org/10.1007/s00439-008-0593-6
https://doi.org/10.1007/s00439-008-0593-6
Autor:
Charlotte A. Mulcare, Tamiru Oljira Raga, Endashaw Bekele, Ayele Tarekegn, Mohamed F. Elamin, Mark G. Thomas, Farouk M. Elamin, Michael E. Weale, Dallas M. Swallow, Neil Bradman, Catherine J. E. Ingram
Publikováno v:
Human Genetics. 120:779-788
Persistence or non-persistence of lactase expression into adult life is a polymorphic trait that has been attributed to a single nucleotide polymorphism (C-13910T) in an enhancer element 13.9 kb upstream of the lactase gene (LCT). The -13910*T allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c21944674ad5da531f89775d305f3c1
https://doi.org/10.1007/s00439-006-0291-1
https://doi.org/10.1007/s00439-006-0291-1
Publikováno v:
eLS
Variation in the ability of adult humans to digest the lactose in milk is a genetically determined trait that has excited the interest of many for the past 50 years. The trait seems to have risen to high frequencies by one of the strongest selection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f268ef05b389823ee215ab55562996df
https://doi.org/10.1002/9780470015902.a0020855.pub2
https://doi.org/10.1002/9780470015902.a0020855.pub2
Autor:
Gernot Kriegshäuser, Ralf Weiskirchen, Catherine J. E. Ingram, Dallas M. Swallow, Axel M. Gressner, Carmen G. Tag, Christian Oberkanins, Maximilian Ledochowski
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 392(1-2)
Background Adult-type hypolactasia is a genetically determined inability to digest lactose after weaning. Two single-nucleotide polymorphisms ( C-13910T , G-22018A ) located upstream of the lactase gene ( LCT ) within the gene MCM6 are associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d923a17f5adefd970c05e97a7ba8fd14
https://pubmed.ncbi.nlm.nih.gov/18396155
https://pubmed.ncbi.nlm.nih.gov/18396155
Autor:
Senait Mengsteab, Ralf Weiskirchen, Catherine J. E. Ingram, Carmen G. Tag, Dallas M. Swallow, Axel M. Gressner
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 384(1-2)
Background: Patients presenting with symptoms of lactose intolerance are in some centres routinely tested for a single-nucleotide polymorphism C-13910T, which is located upstream of the lactase gene (LCT) and is tightly associated with genetically de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec922f5b04732ce613fe0dfda6f4ef09
https://pubmed.ncbi.nlm.nih.gov/17651714
https://pubmed.ncbi.nlm.nih.gov/17651714
Autor:
Neil Bradman, Martine Bolhaar, Catherine J. E. Ingram, Peter Reiss, Lilanganee Telisinghe, Alan Karstaedt, Alison D. Grant, Rosemary Ekong, Alejandro Arenas-Pinto, Rainer Weber, Ian V. D. Weller
Publikováno v:
Antiviral therapy, 17(2), 275-282. International Medical Press Ltd
Background Genetic predisposition to dideoxynucleoside-induced mitochondrial dysfunction might be related to mitochondrial DNA (mtDNA) polymorphisms. Severe hyperlactataemia is probably the best model to assess such a predisposition. Methods For this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5db734923b6212644eed2d1fcdbedf4
https://doi.org/10.3851/imp2259
https://doi.org/10.3851/imp2259