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Aberrant Wound Healing and TGF-β Production in the Autoimmune-Prone MRL/+ Mouse

Autor: J Jones-Carson, V A Fadok, Scott K. Young, J A Kench, G. S. Worthen, D M Russell, David Nemazee, Henson Pm, J E Henson

Publikováno v: Clinical Immunology. 92:300-310

Wound healing is a complex process that involves inflammation, apoptosis, growth, and tissue remodeling. The autoimmune-prone inbred mouse strain MRL/+ manifests accelerated and extensive healing to ear punch wounds, suggesting a link between immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5daa1b2ed7650af4c9aab8be070bd0c0
https://doi.org/10.1006/clim.1999.4754

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The subcellular distribution of platelet-activating factor in stimulated human neutrophils

Autor: D W Riches, S K Young, J F Seccombe, J E Henson, K L Clay, P M Henson

Publikováno v: The Journal of Immunology. 145:3062-3070

Exposure of human peripheral blood neutrophils to a variety of phagocytic and soluble stimuli is known to induce the synthesis and secretion of platelet-activating factor (PAF), a unique ether-linked phospholipid. It has recently been observed in thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab6b9b02e422c47fd6c45461f97ae701
https://doi.org/10.4049/jimmunol.145.9.3062

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The Pulmonary Vascular Sequestration of Neutrophils in Endotoxemia is Initiated by an Effect of Endotoxin on Neutrophil in the Rabbit

Autor: P C Giclas, G. S. Worthen, D C Morrison, Christopher Haslett, J. E. Henson, Peter M. Henson

Publikováno v: American Review of Respiratory Disease. 136:9-18

Endotoxemia causes neutrophil sequestration in the pulmonary vascular bed. Such sequestration may be a critical initiating event in the generation of microvascular injury, although the mechanisms that lead to this localization are not understood. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac4469510ffb86e2d637cd42bd1ec50
https://doi.org/10.1164/ajrccm/136.1.9

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Incorporation of arachidonic acid into lipids of the isolated perfused rat lung

Autor: F. H. Chilton, Norbert F. Voelkel, J. E. Henson, L. M. Zapp, Jay Y. Westcott

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 66(6)

This study has attempted to identify the cells and phosphoglyceride molecular species associated with the rapid turnover of arachidonic acid (AA) in the isolated rat lung. In initial studies, AA complexed to trace amounts of albumin was added to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd35bb4fb4e541952cf1e40b4c70fd3
https://pubmed.ncbi.nlm.nih.gov/2545663

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Identification of rat alveolar type II epithelial cells with a tannic acid and polychrome stain

Autor: R J, Mason, S R, Walker, B A, Shields, J E, Henson, M C, Williams

Publikováno v: The American review of respiratory disease. 131(5)

Alveolar type II epithelial cells are identified by the presence of characteristic lamellar inclusions visualized by transmission electron microscopy. We developed a tannic acid and polychrome stain that can visualize these intracellular inclusions i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21af74d2c81ca999e066b04de3f0fc2a
https://pubmed.ncbi.nlm.nih.gov/2408525

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Lung vascular injury induced by chemotactic factors: enhancement by bacterial endotoxins

Autor: G S, Worthen, C, Haslett, L A, Smedly, A J, Rees, R S, Gumbay, J E, Henson, P M, Henson

Publikováno v: Federation proceedings. 45(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64b6d5942754c92f367c294be5db21b5
https://pubmed.ncbi.nlm.nih.gov/3510132

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Metabolism of platelet-activating factor in isolated perfused rat lung

Autor: Robert C. Murphy, P E Haroldsen, Peter M. Henson, J E Henson, Norbert F. Voelkel

Publikováno v: The Journal of clinical investigation. 79(6)

The administration of platelet-activating factor (PAF) into the airway system of the lung is known to cause profound effects, yet little is known about the metabolism of this active lipid mediator. 3H-Labeled PAF administered into the airway of isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612d2f82b31759b8d0f2b8c586eecac6
https://pubmed.ncbi.nlm.nih.gov/3108322

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Enhancement of pulmonary inflammation by PGE2: evidence for a vasodilator effect

Autor: Peter M. Henson, Gregory P. Downey, Dennis E. Doherty, J. E. Henson, R. S. Gumbay, G. S. Worthen, J. F. LaBrecque

Publikováno v: Scopus-Elsevier

We explored the potential proinflammatory effect of prostaglandins of the E series (PGE's) in a rabbit model of acute pulmonary inflammation. The instillation of fragments of the fifth component of complement (C5f) into the lung resulted in a localiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6c5baf94a531badc76f9fc2c03343e
https://pubmed.ncbi.nlm.nih.gov/3163686

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Modification by hyperoxia in vivo of endotoxin-induced neutrophil alveolitis in rats. Production of chemotactic factors by alveolar macrophages and ultrastructure

Autor: J W, Christman, J E, Rinaldo, J E, Henson, S A, Moore, J H, Dauber

Publikováno v: The American review of respiratory disease. 132(1)

We have previously shown that prior exposure to hyperoxia intensifies the influx of polymorphonuclear leukocytes into bronchoalveolar spaces after endotoxemia (E), but the mechanism is unknown. Because pulmonary alveolar macrophages (PAM) regulate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::704587646e4c1b24de9719d2589e8cdc
https://pubmed.ncbi.nlm.nih.gov/3893245

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