Zobrazeno 1 - 10
of 19
pro vyhledávání: '"J E DeClue"'
Publikováno v:
Molecular and Cellular Biology. 13:6799-6809
Morphological transformation of NIH 3T3 cells was observed following coexpression of a portion of the ras GTPase-activating protein (GAP) comprising the amino terminus (GAP-N) and a mutant of v-src (MDSRC) lacking the membrane-localizing sequence. Ce
Publikováno v:
Molecular and Cellular Biology. 11:3132-3138
A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature sensitive: Ile-36 changed to Leu, Ser-39 changed to Cys (
Autor:
P A, Nguyen-Vu, I, Fackler, A, Rust, J E, DeClue, C A, Sander, M, Volkenandt, M, Flaig, R S, Yeung, R, Wienecke
Publikováno v:
Journal of cutaneous pathology. 28(9)
Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disorder associated with an alteration of the TSC2 tumor suppressor gene which encodes for the protein product tuberin. The disease is characterized by the development of hamartoma
Publikováno v:
The Journal of biological chemistry. 272(46)
Tuberous sclerosis is an autosomal dominant disorder characterized by the development of benign growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The TSC2 gene on chromosome
Publikováno v:
Journal of neuroscience research. 49(2)
Schwann cell proliferation is stimulated by contact with neurons or exposure to growth factor ligands for tyrosine kinase receptors, effects of which are potentiated by cAMP. Here we show that treatment of rat Schwann cells with recombinant human gli
Publikováno v:
Oncogene. 13(10)
The substrate requirements for the catalytic activity of the mouse Cdc25 homolog Guanine nucleotide Release Factor, GRF, were determined using the catalytic domain of GRF expressed in insect cells and E. coli expressed H-Ras mutants. We found a requi
Autor:
R, Wienecke, J C, Maize, F, Shoarinejad, W C, Vass, J, Reed, J S, Bonifacino, J H, Resau, J, de Gunzburg, R S, Yeung, J E, DeClue
Publikováno v:
Oncogene. 13(5)
Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome characterized by the development of tumors in a variety of tissues. We have previously shown that tube
Publikováno v:
Oncogene. 11(2)
Schwann cells are thought to be abnormal in type 1 neurofibromatosis (NF1) and to contribute to the formation of benign and malignant tumors in this disease. To test the role of the NF1 gene product neurofibromin as a Ras-GTPase activating protein in
Publikováno v:
Molecular and cellular biology. 13(11)
Morphological transformation of NIH 3T3 cells was observed following coexpression of a portion of the ras GTPase-activating protein (GAP) comprising the amino terminus (GAP-N) and a mutant of v-src (MDSRC) lacking the membrane-localizing sequence. Ce
Autor:
D R, Lowy, M R, Johnson, J E, DeClue, H, Cen, K, Zhang, A G, Papageorge, W C, Vass, B M, Willumsen, M B, Valentine, A T, Look
Publikováno v:
Ciba Foundation symposium. 176
We are studying the biological activity and regulation of mammalian Ras protein in tumours and in physiological signalling. We have shown that GAP (the GTPase-activating protein) is a potent negative regulator of normal Ras in cells. Reduction or los