Zobrazeno 1 - 10
of 66
pro vyhledávání: '"J E Darnell"'
Publikováno v:
Molecular and Cellular Biology. 15:1312-1317
We have isolated U6A, a mutant cell line which lacks the STAT2 subunit of the transcription factor interferon (IFN)-stimulated gene factor 3 (ISGF3). The response of U6A cells to IFN-alpha is almost completely defective, but the response to IFN-gamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea2f9238cf806d20511eca079c20dc8
https://doi.org/10.1128/mcb.15.3.1312
https://doi.org/10.1128/mcb.15.3.1312
Publikováno v:
The Journal of Experimental Medicine
Activated monocytes play an important role in the pathogenesis of inflammatory arthritis. Blood monocytes which enter the inflamed joint become activated upon adherence to extracellular matrix and exposure to a complex inflammatory environment. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68c8cec9630654d1058f451cb9525b9
http://europepmc.org/articles/PMC2191917
http://europepmc.org/articles/PMC2191917
Autor:
Glen Lindwall, Ke Shuai, Stephen E. Maher, Khuda Dad Khan, J. E. Darnell, Alfred L. M. Bothwell
Publikováno v:
Proceedings of the National Academy of Sciences. 90:6806-6810
The murine Ly-6A/E gene is transcriptionally induced in cells exposed to interferon alpha/beta or gamma (IFN-alpha/beta or IFN-gamma). Analysis of the 5' flanking sequence using reporter plasmids that contain upstream elements of the Ly-6E gene has p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4344638b70cce78f0170c596fd3ddb
https://doi.org/10.1073/pnas.90.14.6806
https://doi.org/10.1073/pnas.90.14.6806
Autor:
Y, Kanno, C A, Kozak, C, Schindler, P H, Driggers, D L, Ennist, S L, Gleason, J E, Darnell, K, Ozato
Publikováno v:
Molecular and Cellular Biology. 13:3951-3963
ICSBP, a member of the interferon regulatory factor family, is expressed predominantly in lymphoid tissues and is induced by gamma interferon (IFN-gamma). We have studied the genomic organization of the murine ICSBP gene and its 5' upstream region. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b93932a6eb5fff55fa8084aa39b7a3a
https://doi.org/10.1128/mcb.13.7.3951-3963.1993
https://doi.org/10.1128/mcb.13.7.3951-3963.1993
Publikováno v:
The EMBO Journal. 11:127-133
The transcription rates of the albumin and alpha-fetoprotein (alpha FP) genes were reduced to marginally detectable levels in livers of newborn or fetal c14CoS albino deletion mutant mice, which lack the hepatocyte specific developmental regulation (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba03c876e952bfc7a1ebb02a4e5f2bfc
https://doi.org/10.1002/j.1460-2075.1992.tb05035.x
https://doi.org/10.1002/j.1460-2075.1992.tb05035.x
Publikováno v:
The Journal of Cell Biology
Inhibition of protein synthesis by puromycin (100 gamma/ml) is known to inhibit the synthesis of ribosomes. However, ribosomal precursor RNA (45S) continues to be synthesized, methylated, and processed. Cell fractionation studies revealed that, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0208f1246399a55869cb360c79a18b27
https://pubmed.ncbi.nlm.nih.gov/19866729
https://pubmed.ncbi.nlm.nih.gov/19866729
Autor:
F C Kuo, J E Darnell
Publikováno v:
Molecular and Cellular Biology. 11:6050-6058
We previously demonstrated that glutamine synthetase (GS) and ornithine aminotransferase (OAT) mRNAs are expressed in the mouse liver acinus preferentially in pericentral hepatocytes, that is, those immediately surrounding terminal central veins (A.L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3f7e6b079ce680af64eb5d9effd73d
https://doi.org/10.1128/mcb.11.12.6050
https://doi.org/10.1128/mcb.11.12.6050
Publikováno v:
Proceedings of the National Academy of Sciences. 87:6589-6593
The serum thyroxine-binding protein, transthyretin (TTR), is made by hepatocytes and by choroid plexus epithelium in adults and by yolk sac cells in embryogenesis. Four hepatocyte nuclear factors (HNF-1, -3, and -4 and C/EBP) that are present in live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f825ec47bb02779951c378a935b87d
https://doi.org/10.1073/pnas.87.17.6589
https://doi.org/10.1073/pnas.87.17.6589
Publikováno v:
Molecular and Cellular Biology. 10:3896-3905
The far-upstream mouse albumin enhancer (-10.5 to -8.43 kilobases) has both positive and negative regulatory domains which contribute to the rate and tissue specificity of albumin gene transcription. (R. S. Herbst, N. Friedman, J. E. Darnell, Jr., an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e0cecd709c8325593af3ee5d7b9923
https://doi.org/10.1128/mcb.10.8.3896-3905.1990
https://doi.org/10.1128/mcb.10.8.3896-3905.1990
Autor:
J E, Darnell
Publikováno v:
Current topics in microbiology and immunology. 316
Celebrations are certainly in order for the 50th anniversary of the Isaacs/Lindenmann discovery of interferon as a secreted substance of probable cellular origin that conferred resistance to at least four viruses of distinctly different character--in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::572f23676cf885ed125b59449323d0e7
https://pubmed.ncbi.nlm.nih.gov/17969447
https://pubmed.ncbi.nlm.nih.gov/17969447