Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J E, Zuckerman"'
Autor:
J M, Glover, J M, Leeds, T G, Mant, D, Amin, D L, Kisner, J E, Zuckerman, R S, Geary, A A, Levin, W R, Shanahan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(3)
Healthy male volunteers received single or multiple intravenous infusions of an intercellular adhesion molecule-1 antisense phosphorothioate oligodeoxynucleotide, ISIS 2302, in a rising-dose (0.06-2.00 mg/kg infused over 2 hr), double-blind, placebo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d77507e21c746ca59488c2d6dc56526d
https://pubmed.ncbi.nlm.nih.gov/9316823
https://pubmed.ncbi.nlm.nih.gov/9316823
Publikováno v:
Anti-cancer drug design. 12(1)
The toxicological properties of ISIS 3082, a phosphorothioate oligonucleotide, and five structurally related analogs of ISIS 3082, were examined in Balb/c mice. Comparisons were made between the uniform phosphorothioate oligonucleotide (ISIS 3082), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9acac0a74bba28920183db0759fe7ec
https://pubmed.ncbi.nlm.nih.gov/9051110
https://pubmed.ncbi.nlm.nih.gov/9051110
Autor:
S T, Crooke, M J, Graham, J E, Zuckerman, D, Brooks, B S, Conklin, L L, Cummins, M J, Greig, C J, Guinosso, D, Kornbrust, M, Manoharan, H M, Sasmor, T, Schleich, K L, Tivel, R H, Griffey
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
Biophysical and pharmacokinetic properties of five analogs of ISIS 3082, a 20-mer phosphorothioate oligodeoxynucleotide that inhibits the expression of mouse intercellular adhesion molecule 1, were evaluated. Compared to the parent compound, ISIS 308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d2defa0c01a053d57855b82849fe768
https://pubmed.ncbi.nlm.nih.gov/8627575
https://pubmed.ncbi.nlm.nih.gov/8627575
Publikováno v:
Molecular biotherapy. 4(3)
Toxins may be specifically directed to tumor cells and the toxins' potency greatly increased by covalent conjugation to monoclonal antibodies recognizing tumor-associated antigens. Antibody 15A8, an immunoglobulin G1 (IgG1) subclass anti-human breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::509245974a14724e42fa15fabb28bdb2
https://pubmed.ncbi.nlm.nih.gov/1445665
https://pubmed.ncbi.nlm.nih.gov/1445665
Autor:
J E, Zuckerman
Publikováno v:
Lancet (London, England). 1(7851)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f035f14ddb3fed82c455fdc3762dedd
https://pubmed.ncbi.nlm.nih.gov/4130261
https://pubmed.ncbi.nlm.nih.gov/4130261
Publikováno v:
The American review of respiratory disease. 121(2)
The administration of an acute pulmonary edemagenic dose (ip) of thiourea to rats results in an elevation of angiotensin converting enzyme (ACE) in serum, lung lavage, and pleural effusion. The increased serum ACE corresponds to a reduction in lung A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b78585642d69356b80042ec26867f89b
https://pubmed.ncbi.nlm.nih.gov/6244767
https://pubmed.ncbi.nlm.nih.gov/6244767
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 213(3)
Endotracheal administration of bleomycin to hamsters causes severe pulmonary fibrosis. We have examined the utility of this response as a model for the screening of pulmonary antifibrotic agents. The time course of collagen synthesis after bleomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::296db382e3b27897be1f1e599639b999
https://pubmed.ncbi.nlm.nih.gov/6162945
https://pubmed.ncbi.nlm.nih.gov/6162945
Publikováno v:
Research communications in chemical pathology and pharmacology. 31(2)
Administration of endotoxin prior to an LD50 dose of thiourea protected rats against pulmonary edema and pleural effusion. These results are similar to those seen with endotoxin pretreatment and pulmonary O2 toxicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d8e610197044346a8262b4b6535a4c1
https://pubmed.ncbi.nlm.nih.gov/6784199
https://pubmed.ncbi.nlm.nih.gov/6784199
Publikováno v:
The American review of respiratory disease. 121(5)
Intraperitoneal administration of paraquat to mice produced a linear dose-response increase (20 to 50 mg/kg of body weight) in serum angiotensin converting enzyme (ACE). The peak increase (31%) in ACE occurred after 50 mg/kg of paraquat and began at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::213307c4b7b070ecc286a435b2b34ba1
https://pubmed.ncbi.nlm.nih.gov/6250433
https://pubmed.ncbi.nlm.nih.gov/6250433
Publikováno v:
Cancer research. 46(4 Pt 1)
A subline of B16 melanoma cells which is 10-fold resistant to bleomycin (BLM) was developed by exposure of the parental cell line to sequential increases in BLM concentration. This resistance to BLM is stable for over 30 passages in drug-free medium.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::947025a4aae3cf7a58c2593263abf8cd
https://pubmed.ncbi.nlm.nih.gov/2418953
https://pubmed.ncbi.nlm.nih.gov/2418953