Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J E, Smolen"'
Publikováno v:
The Journal of Immunology. 144:3936-3945
We have identified two major proteins in human neutrophils that are phosphorylated in vitro by protein kinase C (PKC) as lipocortins III and a fragment of a lipocortin-like 68-kDa protein. In electroporated cells, the 68-kDa protein was phosphorylate
Publikováno v:
Blood. 75:1324-1332
Exposure of human neutrophils to micromolar concentrations of both hydrolyzable and nonhydrolyzable purine nucleotides caused the generation of transient rises in intracellular calcium (Ca2+), Ca2+ fluxes across the membrane, and primed the cells for
Publikováno v:
Aviation, space, and environmental medicine. 71(12)
The effects of long-term spaceflight on inflammatory responses have not been well-studied in either humans or animals. It is thus important to determine if the functions of immune and inflammatory cells are altered in models of spaceflight. One such
Autor:
J E, Smolen
Publikováno v:
The Journal of laboratory and clinical medicine. 120(4)
Publikováno v:
Immunology series. 57
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 144(10)
We have identified two major proteins in human neutrophils that are phosphorylated in vitro by protein kinase C (PKC) as lipocortins III and a fragment of a lipocortin-like 68-kDa protein. In electroporated cells, the 68-kDa protein was phosphorylate
Autor:
J E Smolen, S J Stoehr
Publikováno v:
The Journal of Immunology. 134:1859-1865
Permeabilization of human neutrophils has been accomplished by using saponin, a cholesterol complexing agent, permitting experimental manipulation of the intracellular milieu. Access of ordinarily impermeable solutes, such as [14C]-inulin or [14C]-su
Publikováno v:
The Journal of Immunology. 137:1665-1673
A Ca2+-activated and phospholipid-dependent protein kinase (PKC) has been described in several cell systems, including the human neutrophil. We found that less than 30 pmol 32P/10 min/10(6) cell equivalents of phorbol ester- or 1-oleoyl-2-acetylglyce
Publikováno v:
The Journal of biological chemistry. 262(1)
Intact neutrophils exhibit interconverting active and inactive receptor states with half-times for dissociation of 10 s and 2 min, respectively. We examined the effect of guanine nucleotides on ligand-receptor dynamics at 37 degrees C in neutrophils
Autor:
L A, Boxer, J E, Smolen
Publikováno v:
Hematology/oncology clinics of North America. 2(1)
In this review of secretion by neutrophils, we have given a detailed description of the characteristics of the exocytotic responses of these cells to a variety of stimuli. Secretion of the contents of the two types of granules follows different rules