Výsledky vyhledávání - "J E, Schurig"

Experimental tumor inhibitory and toxic properties of the mitomycin A analogue 7-(2-hydroxyethoxy) mitosane (BMY-25551)

Autor: W T, Bradner, J J, Catino, B H, Long, W C, Rose, J E, Schurig

Publikováno v: Anticancer research. 12(3)

BMY-25551, 7-(2-hydroxyethoxy)mitosane, was selected from a series of mitomycin A (MMA) analogues for more detailed study. As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to mur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a65a79553be73412d8fbb02b9dde7a0
https://pubmed.ncbi.nlm.nih.gov/1622154

Zobrazit plný text záznamu

Antitumor and DNA-binding properties of a group of oligomeric complexes of Pt(II) and Pt(IV)

Autor: A, Peritz, S, al-Baker, J F, Vollano, J E, Schurig, W T, Bradner, J C, Dabrowiak

Publikováno v: Journal of medicinal chemistry. 33(8)

The antitumor and DNA-binding properties of a group of oligomeric platinum(II) and platinum(IV) complexes are described. The compounds, having the stoichiometry [cis-PtII(X)2(mu-OH)]2(NO3)2, where X is NH3, NH2CH2CH3, and NH2CH(CH3)2, were found to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca4622826ab46eddd0e067798fc3531c
https://pubmed.ncbi.nlm.nih.gov/2374144

Zobrazit plný text záznamu

ChemInform Abstract: cis-Diamineplatinum(II) Complexes Containing Phosphonocarboxylate Ligands as Antitumor Agents

Autor: Alan R. Amundsen, A. V. Miller, Eric W. Stern, J. E. Schurig, L. S. Hollis

Publikováno v: ChemInform. 21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::985b2621c5b21bc796977eaf42091f19
https://doi.org/10.1002/chin.199022312

Zobrazit plný text záznamu

cis-diamineplatinum (II) complexes containing phosphono carboxylate ligands as antitumor agents

Autor: L. S. Hollis, Eric W. Stern, Alan R. Amundsen, J. E. Schurig, A. V. Miller

Publikováno v: Journal of medicinal chemistry. 33(1)

A series of platinum complexes of the form cis-M[PtA2(PC)] (I) has been prepared and tested for antitumor activity in mice. Compounds in this series contain either two monodentate amine ligands (A), such as NH3 or isopropylamine, or one bidentate dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968caa8b01e9aa7066f072f255dc4255
https://pubmed.ncbi.nlm.nih.gov/2296007

Zobrazit plný text záznamu

Effects of Tiodazosin, Prazosin, Trimazosin and Phentolamine on Blood Pressure, Heart Rate and on Pre- and Postsynaptic α-Adrenergic Receptors in the Rat

Autor: J. E. Schurig, J. A. Campbell, A. W. Pircio, J. P. Buyniski

Publikováno v: Clinical and Experimental Hypertension. 2:1039-1066

Subcutaneous administration of tiodazosin (0.1-3 mg/kg), prazosin (0.01-1 mg/kg), trimazosin (10-30 mg/kg) and phentolamine (0.1-3 mg/kg) to conscious spontaneously hypertensive rats (SHR) produced graded decreases in blood pressure with the order of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30feed3dac5a8a261886ef8ed2ef4e3
https://doi.org/10.3109/10641968009037160

Zobrazit plný text záznamu

ChemInform Abstract: MITOMYCIN C AND PORFIROMYCIN ANALOGS WITH SUBSTITUTED ETHYLAMINES AT POSITION 7

Autor: J. E. Schurig, S. M. Sami, Bhashyam S. Iyengar, William A. Remers, W. T. Bradner

Publikováno v: Chemischer Informationsdienst. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a1d13509004ed2ac487d81032bfbf09
https://doi.org/10.1002/chin.198326348

Zobrazit plný text záznamu

ChemInform Abstract: MITOMYCIN C ANALOGS WITH ARYL SUBSTITUENTS ON THE 7-AMINO GROUP

Autor: William A. Remers, S. M. Sami, S. E. Tarnow, J. E. Schurig, Bhashyam S. Iyengar, W. T. Bradner

Publikováno v: Chemischer Informationsdienst. 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d372c63dbbeeb2602de9a22524e84c32
https://doi.org/10.1002/chin.198445360

Zobrazit plný text záznamu

Pulmonary toxicity studies of bleomycin and talisomycin

Autor: A, Schlein, J E, Schurig, C, Baca, W T, Bradner, S T, Crooks

Publikováno v: Cancer treatment reports. 65(3-4)

The comparative pulmonary toxicity induced by bleomycin and talisomycin (former trivial name: tallysomycin A) was evaluated by measuring lung hydroxyproline content. Based on published subacute toxicity data, in which talisomycin was found to be four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54e4bb4acaa14e13fd8b29023ec93714
https://pubmed.ncbi.nlm.nih.gov/6165468

Zobrazit plný text záznamu

Effect of butorphanol and morphine on pulmonary mechanics, arterial blood pressure and venous plasma histamine in the anesthetized dog

Autor: J E, Schurig, R L, Cavanagh, J P, Buyniski

Publikováno v: Archives internationales de pharmacodynamie et de therapie. 233(2)

Butorphanol, levo-N-cyclobutylmethyl-3, 14beta-dihydroxy-morphinan, is a new agonist-antagonist type analgetic agent which is 4 times more potent than morphine in experimental animals. Equianalgetic doses of butorphanol and morphine were compared, fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b499fcfbc93df736d41d34b389860011
https://pubmed.ncbi.nlm.nih.gov/686916

Zobrazit plný text záznamu

Animal models for evaluating the myelosuppressive effects of cancer chemotherapeutic agents

Autor: J E, Schurig, A, Schlein, A P, Florczyk, A R, Farwell, W T, Bradner

Publikováno v: Experimental hematology. 13

An important objective of new anticancer drug discovery programs is identification of agents that are less myelosuppressive than those currently available. We have developed several animal models to evaluate these drugs for myelosuppression. Our scre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4de47de76a1edcd875a7b2a7f898112
https://pubmed.ncbi.nlm.nih.gov/3987834

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání