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OP0124 FETAL AND MATERNAL MORBIDITY IN PREGNANT SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS: A 10-YEAR U.S. NATIONAL STUDY

Autor: B. Mehta, K. K. J. Glaser, D. Jannat-Khah, Y. Luo, L. Sammaritano, J. E. Salmon, S. Goodman, F. Wang

Publikováno v: Annals of the Rheumatic Diseases. 81:80-81

BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disorder that affects women in their childbearing years. Previously, we demonstrated that fetal and maternal mortality has declined in SLE patients over the years, however little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3396468d504eed5e621245e0b8c25bcf
https://doi.org/10.1136/annrheumdis-2022-eular.3226

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PATHOLOGY: IMMUNE AND INFLAMMATORY MECHANISMS

Publikováno v: Nephrology Dialysis Transplantation. 29:iii448-iii450

2 and 3 were observed in 43%, 47% and 10% of these specimens. Leucocyte subpopulations were categorized focal vs. diffuse monocytic (11%/24%), focal vs. diffuse granulocytic (4%/4%), or focal vs. diffuse mixed (14%/20%). In 23% of the cases ptc was n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdfe157867d5d9f88105d4d3aab1b524
https://doi.org/10.1093/ndt/gfu171

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Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function

Autor: J E Salmon, N Brogle, C Brownlie, J C Edberg, R P Kimberly, B X Chen, B F Erlanger

Publikováno v: The Journal of Immunology. 151:2775-2785

Using monoclonal anti-adenosine A1 receptor antibodies that bind the A1 receptor ligand binding site, we demonstrate that A1 receptors are expressed on cultured monocytes and rheumatoid synovial fluid mononuclear phagocytes. This finding is associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56f4326958a76a8acbf1b6ff3a79e2a5
https://doi.org/10.4049/jimmunol.151.5.2775

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The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia

Autor: A M, Lynch, J R, Murphy, R S, Gibbs, R J, Levine, P C, Giclas, J E, Salmon, V M, Holers

Publikováno v: BJOG : an international journal of obstetrics and gynaecology. 117(4)

To determine the interrelationships during early pregnancy of complement-activation fragments Bb, C3a and sC5b-9, and angiogenesis-related factors placental growth factor (PiGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::727ee711867a00a889c9f241cf507184
https://pubmed.ncbi.nlm.nih.gov/20074261

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Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II

Autor: J E Salmon, N L Brogle, J C Edberg, R P Kimberly

Publikováno v: The Journal of Immunology. 146:997-1004

Human polymorphonuclear leukocytes (PMN) express two classes of Fc gamma R: Fc gamma RII the 42-kDa receptor with a traditional membrane spanning domain and cytoplasmic tail and Fc gamma RIIIPMN the 50- to 80-kDa receptor with a glycosyl-phatidylinos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef12071a94053136c57e27cf13871550
https://doi.org/10.4049/jimmunol.146.3.997

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Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory

Autor: J E Salmon, B N Cronstein

Publikováno v: The Journal of Immunology. 145:2235-2240

Adenosine, an endogenously released purine, modulates the functions of many cells through surface A1 and A2 receptors. We examined the hypothesis that adenosine receptor ligation regulates Fc gamma R-triggered inflammatory response by polymorphonucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7f56aded25dde43db4dc9b9665b2163
https://doi.org/10.4049/jimmunol.145.7.2235

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Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells

Autor: J C Edberg, M Barinsky, P B Redecha, J E Salmon, R P Kimberly

Publikováno v: The Journal of Immunology. 144:4729-4734

Fc gamma RIII is a family of protein isoforms encoded by at least two distinct, yet highly homologous, genes. Fc gamma RIII on neutrophils is a glycosylphosphatidylinositol-linked protein with an allelic polymorphism (NA1/NA2) while Fc gamma RIII on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21c9507d95df808c58c999e5cdc052e1
https://doi.org/10.4049/jimmunol.144.12.4729

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Human receptors for immunoglobulin G: key elements in the pathogenesis of rheumatic disease

Autor: J E, Salmon, L, Pricop

Publikováno v: Arthritis and rheumatism. 44(4)

The structural diversity of Fc gammaR provides a mechanism by which IgG can elicit a broad range of cell responses. Fc gammaR vary in their affinity for IgG, their preference for IgG subclasses, the cell types in which they are expressed, and the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7168072b9cc5117e3cb176ad956a3804
https://pubmed.ncbi.nlm.nih.gov/11315912

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Identification of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphospholipid antibody-induced thrombogenic phenotype

Autor: S S, Pierangeli, R, Espinola, X, Liu, E N, Harris, J E, Salmon

Publikováno v: Arthritis and rheumatism. 44(4)

Patients with the antiphospholipid antibody syndrome (APS) often experience recurrent arterial and venous thrombosis and pregnancy losses. Intravenous immunoglobulin (IVIG) therapy has prevented pregnancy loss in some women with APS and has reversed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76a198cd617debff4d891ba192f0c8ea
https://pubmed.ncbi.nlm.nih.gov/12730514

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