Zobrazeno 1 - 10
of 42
pro vyhledávání: '"J E, Saavedra"'
Publikováno v:
Xenobiotica. 32:339-347
1. The single-dose plasma pharmacokinetics of O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) following intravenous (i.v.) and intraperitoneal (i.p.) bolus administration to the male C57BL/6 mouse was studied in an effort to chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816ffe94c3f794c05924941236fa1aed
https://doi.org/10.1080/00498250110102665
https://doi.org/10.1080/00498250110102665
Autor:
J. E. Saavedra
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ccb0b931b2aeaf75573af3b3ea419db
https://doi.org/10.1002/chin.199126104
https://doi.org/10.1002/chin.199126104
ChemInform Abstract: β-Keto Nitrosamines as Synthetic Equivalents of α-Methylene Alkanolamino Anions
Autor:
J. E. Saavedra, D. W. Farnsworth
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56735824a77ec41607a37e13d961784
https://doi.org/10.1002/chin.199145119
https://doi.org/10.1002/chin.199145119
Nitric oxide (NO) is a major effector molecule in cancer prevention. A number of studies have shown that NO prodrug JS-K (O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) induces apoptotic cell death in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15efd5c3e17fd279058c37543120462a
https://europepmc.org/articles/PMC2854646/
https://europepmc.org/articles/PMC2854646/
Autor:
J E, Saavedra, A, Srinivasan, C L, Bonifant, J, Chu, A P, Shanklin, J L, Flippen-Anderson, W G, Rice, J A, Turpin, K M, Davies, L K, Keefer
Publikováno v:
The Journal of organic chemistry. 66(9)
Ions of structure R(2)N[N(O)NO](-) and their alkylation products have seen increasing use as nitric oxide (NO)-generating agents for biomedical research applications. Here we show that such diazeniumdiolate anions can readily displace halide from a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e65d27599df8fabf01909e13d2b14dfa
https://pubmed.ncbi.nlm.nih.gov/11325274
https://pubmed.ncbi.nlm.nih.gov/11325274
Autor:
R, Ricciardi, D P, Foley, S H, Quarfordt, J E, Saavedra, L K, Keefer, S M, Wheeler, S E, Donohue, M P, Callery, W C, Meyers
Publikováno v:
Transplantation. 71(2)
The role of nitric oxide (NO) in ischemia reperfusion (I/R) injury is controversial as both beneficial and harmful effects have been reported. We explored the potential role of a pharmacological agent recently shown to generate NO metabolically in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4624a0afa7833e7f0058fe190ab56fb2
https://pubmed.ncbi.nlm.nih.gov/11213058
https://pubmed.ncbi.nlm.nih.gov/11213058
Publikováno v:
Revista de neurologia. 28(9)
Cinnarizine is a calcium-entry blocker drug used in vertiginous disorders; among its most rare adverse effects appear extrapyramidal symptoms and depression, these effects can persist during weeks, months or years after the withdrawal of the drug and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3de66039dde4aefe4503f88aaed22741
https://pubmed.ncbi.nlm.nih.gov/10390751
https://pubmed.ncbi.nlm.nih.gov/10390751
Autor:
H C, Champion, T J, Bivalacqua, R, Wang, P J, Kadowitz, L K, Keefer, J E, Saavedra, J A, Hrabie, P C, Doherty, W J, Hellstrom
Publikováno v:
The Journal of urology. 161(6)
The effects of novel nitric oxide (NO) donors administered intracavernosally and transurethrally on erectile function in the anesthetized cat were evaluated.In pentobarbital-anesthetized cats, increases in intracavernosal pressure, penile length, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48c561abde95e2c519235dffd6d4f1a3
https://pubmed.ncbi.nlm.nih.gov/10332492
https://pubmed.ncbi.nlm.nih.gov/10332492
Publikováno v:
In vivo (Athens, Greece). 5(2)
A number of nitrosamines that have been studied by administration to rats as solutions in drinking water have been examined by gavage administration of similar doses, for assessment of the role of pharmacokinetics in organ-specific carcinogenesis. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa0bb92e377df531e0ef314e2d30a995
https://pubmed.ncbi.nlm.nih.gov/1768792
https://pubmed.ncbi.nlm.nih.gov/1768792
Publikováno v:
In vivo (Athens, Greece). 4(1)
A number of asymmetric nitrosodialkylureas containing ethyl, hydroxyethyl, 2-hydroxypropyl, 2-oxopropyl or chloroethyl on one or the other side of the nitroso function were given to male and female F344 rats in drinking water. The two compounds conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95392d533f68925e12c31cec838329b7
https://pubmed.ncbi.nlm.nih.gov/2103836
https://pubmed.ncbi.nlm.nih.gov/2103836