Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J E, Rubnitz"'
Autor:
W, Leung, J T, Sandlund, M M, Hudson, Y, Zhou, M L, Hancock, Y, Zhu, R C, Ribeiro, J E, Rubnitz, L E, Kun, B, Razzouk, W E, Evans, C H, Pui
Publikováno v:
Cancer. 92(7)
The objective of this report was to determine the cumulative incidence of and risk factors for second malignancy and the competing risk of death due to any other cause among patients who were treated for childhood non-Hodgkin lymphoma (NHL).The autho
Autor:
J E, Rubnitz
Publikováno v:
Journal of biological regulators and homeostatic agents. 14(3)
Somatically acquired genetic alterations play an important role in the pathogenesis of acute lymphoblastic leukemia. The molecular analysis of these alterations has increased our understanding of the mechanisms of leukemogenesis. In addition, this in
Publikováno v:
Genes, chromosomescancer. 28(2)
The MLL gene at 11q23 is frequently disrupted by chromosomal translocations in de novo acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and in secondary leukemia induced by treatment with inhibitors of topoisomerase II, including the e
Publikováno v:
Leukemia. 13(9)
Autor:
C, Ito, M, Kumagai, A, Manabe, E, Coustan-Smith, S C, Raimondi, F G, Behm, K G, Murti, J E, Rubnitz, C H, Pui, D, Campana
Publikováno v:
Blood. 93(1)
To determine the cellular basis for the excellent clinical outcome of hyperdiploid acute lymphoblastic leukemia (ALL), defined by a modal chromosome number of 51 to 65, we assessed the growth potential of leukemic cells from 129 children with newly d
Publikováno v:
Advances in pediatrics. 45
Molecular genetic determinants of malignant diseases in children are providing insights into the mechanisms of malignancies. These findings have improved diagnosis, treatment, and prognosis.
Autor:
C H, Pui, H H, Mahmoud, G K, Rivera, M L, Hancock, J T, Sandlund, F G, Behm, D R, Head, M V, Relling, R C, Ribeiro, J E, Rubnitz, L E, Kun, W E, Evans
Publikováno v:
Blood. 92(2)
Central nervous system (CNS) relapse has been an obstacle to uniformly successful treatment of childhood acute lymphoblastic leukemia (ALL) for many years. We therefore intensified intrathecal chemotherapy (simultaneously administered methotrexate, h
Autor:
J E, Rubnitz, J J, Shuster, V J, Land, M P, Link, D J, Pullen, B M, Camitta, C H, Pui, J R, Downing, F G, Behm
Publikováno v:
Blood. 89(4)
TEL gene rearrangement is the most common genetic lesion in pediatric acute lymphoblastic leukemia (ALL), occurring in about 25% of B-lineage cases. We previously showed that, among patients treated on St Jude protocols, TEL rearrangement independent
Publikováno v:
Leukemia. 10(9)
Cryptic t(12;21)(p12-13;q22) leading to TEL-AML1 fusion has recently been recognized as the most frequent genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) in Western countries. More recently, we found a similar frequency of this
Autor:
J E, Rubnitz, F G, Behm, A M, Curcio-Brint, R P, Pinheiro, A J, Carroll, S C, Raimondi, S A, Shurtleff, J R, Downing
Publikováno v:
Blood. 87(11)
MLL is fused to ENL or ELL in acute leukemias that contain t(ll;19)(q23;p13). Although ENL and ELL localize to chromosome 19, bands p13.3 and p13.1, respectively, these breakpoints are not always readily distinguished by standard cytogenetics. We the