Výsledky vyhledávání - "J E, LoSardo"

Restoration of the transcription activation function to mutant p53 in human cancer cells

Autor: P, Abarzúa, J E, LoSardo, M L, Gubler, R, Spathis, Y A, Lu, A, Felix, A, Neri

Publikováno v: Oncogene. 13(11)

The p53 tumor suppressor gene product is a sequence-specific transcription activator frequently mutated in a variety of human malignancies. Typically, tumor-derived p53 missense mutants are defective in DNA binding and this is likely to result in a f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff4a98b8640042c2e7c696641309c2ad
https://pubmed.ncbi.nlm.nih.gov/8957091

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Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53

Autor: P, Abarzúa, J E, LoSardo, M L, Gubler, A, Neri

Publikováno v: Cancer research. 55(16)

The p53 tumor suppressor is a transcription factor frequently mutated in human malignancies. Tumor-derived p53 missense mutants are defective in sequence-specific DNA binding and fail to activate p53 target genes. mAb PAb421 was shown previously to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff904197a0a475319a833fd5f3d444ac
https://pubmed.ncbi.nlm.nih.gov/7627952

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Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP

Autor: J E, Scheffler, D S, Waugh, E, Bekesi, S E, Kiefer, J E, LoSardo, A, Neri, K M, Prinzo, K L, Tsao, B, Wegrzynski, S D, Emerson

Publikováno v: The Journal of biological chemistry. 269(35)

Four overlapping peptide fragments of human c-Raf-1 (residues 55-132, 55-117, 77-132, and 77-117) were expressed in Escherichia coli as carboxyl-terminal extensions of maltose binding protein (MBP). The MBP-Raf fusions were purified by affinity chrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54c5f0203e34fd3a0f6a5d5eab19f8d6
https://pubmed.ncbi.nlm.nih.gov/8071362

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Relative importance of elements within the SL3-3 virus enhancer for T-cell specificity

Autor: J E LoSardo, A L Boral, Jack Lenz

Publikováno v: Journal of virology. 64(4)

Elements within the enhancer of T-lymphomagenic SL3-3 virus were examined for their contributions to transcriptional activity in T lymphocytes and non-T cells. A region containing two sequences homologous to the enhancer core consensus sequence and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb286c00e6856e7d9846ec698dd55028
https://pubmed.ncbi.nlm.nih.gov/2157056

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Differences in activities of murine retroviral long terminal repeats in cytotoxic T lymphocytes and T-lymphoma cells

Autor: J W Berman, Jack Lenz, M K Short, Lisa A. Cupelli, J E LoSardo

Publikováno v: Journal of Virology. 63:1087-1094

Transcriptional activities of the long terminal repeats (LTRs) of various murine leukemia viruses were tested in the cytotoxic T-cell lines CTLL-1 and CTLL-2. In contrast to T-lymphoma cells, in which the LTRs of T-lymphomagenic virus SL3-3 and Molon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722123f6e8c2508d31f4d6968d4ce91c
https://doi.org/10.1128/jvi.63.3.1087-1094.1989

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