Zobrazeno 1 - 10
of 129
pro vyhledávání: '"J E, Leysen"'
Autor:
Thomas H. Kramer, Dirk Tourwé, J. Couder, D. Meert, Peg Davis, Thomas F. Burks, J. E. Leysen, M. Ceusters, Henry I. Yamamura, Georges Van Binst, Richard J. Knapp
Publikováno v:
International Journal of Peptide and Protein Research. 39:131-136
The peptide CO-NH function was replaced by a trans carbon-carbon double bond or by a CH2-CH2 isostere in enkephalin analogues of DADLE, DCDCE-NH2 or DPDPE. In DADLE the 2-3 and the 3-4 peptide bond was modified, whereas in the cyclic analogues the Gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5831b92bc6619bd04abe68f3e0309e98
https://doi.org/10.1111/j.1399-3011.1992.tb00782.x
https://doi.org/10.1111/j.1399-3011.1992.tb00782.x
Publikováno v:
International Journal of Peptide and Protein Research. 41:181-184
Each peptide CO-NH function in the biologically important C-terminal 8-13 sequence of neurotensin was replaced by the reduced CH 2 -NH isostere using the rapid in situ solid phase procedure developed by Sasaki & Coy. In general this modification resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb4db01f67cef4904c532dbb55bac49
https://doi.org/10.1111/j.1399-3011.1993.tb00129.x
https://doi.org/10.1111/j.1399-3011.1993.tb00129.x
Autor:
A, Metaxas, R, Willems, E J M, Kooijman, V A, Renjaän, P J, Klein, A D, Windhorst, L Ver, Donck, J E, Leysen, B N M van, Berckel
Publikováno v:
Journal of neuroscience research. 92(11)
Although both the onset of schizophrenia and human phencyclidine (PCP) abuse typically present within the interval from adolescence to early adulthood, the majority of preclinical research employing the PCP model of schizophrenia has been conducted o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c721a07b75a7e771bc25ed680801c3c
https://pubmed.ncbi.nlm.nih.gov/24953757
https://pubmed.ncbi.nlm.nih.gov/24953757
Autor:
Walter Luyten, W. Gommeren, I van Oers, Armelle Nathalie Françoise Pindon, Peter Verhasselt, YB Zhang, Mirek Jurzak, J. E. Leysen, Eckhard Bender
Publikováno v:
Journal of Neurochemistry. 74:478-489
Several variants of the serotonin 5-HT 4 receptor are known to be produced by alternative splicing. To survey the existence and usage of exons in humans, we cloned the human 5-HT 4 gene. Based on sequence analysis seven C-terminal variants (a-g) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e271bc8fdaf3860dd9d186af0cf75d45
https://doi.org/10.1046/j.1471-4159.2000.740478.x
https://doi.org/10.1046/j.1471-4159.2000.740478.x
Autor:
D. Terriere, Kris Chavatte, L. Jeannin, Axel Bossuyt, E. Bruyneel, Dirk Tourwé, Jan A.J. Schuurkes, M.R. Briejer, K. Iterbeke, J. Mertens, J. E. Leysen
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 42:423-435
Neurotensin(8-13) analogues were biologically stabilised by replacement of the peptide bond between amino acids 8 and 9 by the reduced ψ(CH 2 -NH) isostere. Diethylenetriaminepentaacetic acid (DTPA) analogues for In-111 labelling and 2-bromo-phenyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbfcaa3be4d50e7668c288231848019a
https://doi.org/10.1002/(sici)1099-1344(199905)42:5<423::aid-jlcr201>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199905)42:5<423::aid-jlcr201>3.0.co
Autor:
P. Van Gompel, J. E. Leysen, Peter Vanhoenacker, Guy Haegeman, Walter Luyten, A S Lesage, Ria Wouters, Lieve Heylen
Publikováno v:
British Journal of Pharmacology. 123:1655-1665
1. Alniditan, a novel migraine abortive agent, is a potent 5-HT1B/5-HT1D receptor agonist of nM affinity. We compared the agonistic properties of alniditan, sumatriptan and dihydroergotamine on the cloned human 5-HT1B receptor expressed at 200 fmol m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3656f7a24c159eb0e90ece39a615399f
https://doi.org/10.1038/sj.bjp.0701766
https://doi.org/10.1038/sj.bjp.0701766
Autor:
G.H.K. Tjon, P. Nestby, P.F.M. Janssen, Louk J. M. J. Vanderschuren, T.J. de Vries, Arie H. Mulder, J. E. Leysen, Anton N. M. Schoffelmeer, Alain Schotte
Publikováno v:
Synapse. 27:262-265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0cb0119ca5d1d3c2b0c1aa1eb19edc4
https://doi.org/10.1002/(sici)1098-2396(199711)27:3<262::aid-syn10>3.0.co
https://doi.org/10.1002/(sici)1098-2396(199711)27:3<262::aid-syn10>3.0.co
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 39:11-19
4-Amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-2-methoxybenzamide, a compound with high affinity for 5HT 2 -receptors, was radiobrominated in the 5-position of the methoxybenzamide group by electrophilic substitution. Hydrogen perox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a12c53e4c27077a5ab24f024f8a658a3
https://doi.org/10.1002/(sici)1099-1344(199701)39:1<11::aid-jlcr943>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199701)39:1<11::aid-jlcr943>3.0.co
Publikováno v:
The Histochemical Journal. 28:791-799
[3H]7-hydroxy-N,N-di-n-propyl-2-aminotetralin was used as a radioligand for the autoradiographic measurements of dopamine D3 receptors in rat and human brain. Preincubation of the brain sections was necessary to obtain binding of the radioligand in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6fb8fc15c77aea98c7140c6b410bff
https://doi.org/10.1007/bf02272152
https://doi.org/10.1007/bf02272152
Publikováno v:
European Neuropsychopharmacology. 6:S4-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39d5941fedf8c27f264989aa37f3642c
https://doi.org/10.1016/0924-977x(96)83050-1
https://doi.org/10.1016/0924-977x(96)83050-1