Zobrazeno 1 - 10
of 70
pro vyhledávání: '"J E, Lamm"'
Publikováno v:
Journal of Applied Physiology. 128:309-323
To facilitate computational toxicology, we developed an approach for generating high-resolution lung-anatomy and particle-deposition mouse models. Major processing steps of our method include mouse preparation, serial block-face cryomicrotome imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7640e186eaf7c6ecf7232ea50d7ebdcb
https://doi.org/10.1152/japplphysiol.00615.2019
https://doi.org/10.1152/japplphysiol.00615.2019
Autor:
Mineo Iwata, David K Madtes, Kraig Abrams, Wayne J E Lamm, Robb W Glenny, Richard A Nash, Aravind Ramakrishnan, Beverly Torok-Storb
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57179 (2013)
In the current study, we used a canine model of radiation-induced lung injury to test the effect of a single i.v. infusion of 10×10(6)/kg of marrow fibroblasts on the progression of damage following 15 Gy exposure to the right lung. The fibroblasts,
Externí odkaz:
https://doaj.org/article/659c5b4ed0974033b75308977e2dd6c6
Publikováno v:
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol 2 (2008)
Previous studies reported that the degree of hypoxemia following acute pulmonary thromboembolism (APTE) was highly variable and that its mechanism was mainly due to the creation of many high and low ventilation/perfusion (V/Q) units, as a result of t
Externí odkaz:
https://doaj.org/article/07317352edd34fa6a364da44cad23474
Publikováno v:
Journal of Aerosol Science. 99:27-39
Despite substantial development of sophisticated subject-specific computational models of aerosol transport and deposition in human lungs, experimental validation of predictions from these new models is sparse. We collected aerosol retention and exha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19960707085387b505b370f2e485cffc
https://doi.org/10.1016/j.jaerosci.2016.01.019
https://doi.org/10.1016/j.jaerosci.2016.01.019
Autor:
Richard A. Corley, Wayne J. E. Lamm, Daniel R. Einstein, Richard E. Jacob, Robb W. Glenny, Melissa A. Krueger
Publikováno v:
Experimental Lung Research. 41:135-145
Computer models for inhalation toxicology and drug-aerosol delivery studies rely on ventilation pattern inputs for predictions of particle deposition and vapor uptake. However, changes in lung mechanics due to disease can impact airflow dynamics and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf28f08ddf3e32cd44b62feaa39d108
https://doi.org/10.3109/01902148.2014.984085
https://doi.org/10.3109/01902148.2014.984085
Autor:
Wayne J. E. Lamm, Robb W. Glenny, Melissa A. Krueger, Reinhard Beichel, Christian Bauer, Brian J. Smith
Publikováno v:
IEEE Transactions on Biomedical Engineering. 61:119-130
A highly automated method for the segmentation of airways in the serial block-face cryomicrotome images of rat lungs is presented. First, a point inside of the trachea is manually specified. Then, a set of candidate airway centerline points is automa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835115bc83f9eecd4e08510230898676
https://doi.org/10.1109/tbme.2013.2277936
https://doi.org/10.1109/tbme.2013.2277936
Autor:
Wayne J. E. Lamm, John Y. C. Tsang
Publikováno v:
Pulmonary Circulation
We aimed to investigate the role of endothelin-mediated vasoconstriction following acute pulmonary thromboembolism (APTE). Thirteen anesthetized piglets (~25 kg) were ventilated with 0 PEEP. Cardiac output (Qt) and wedge pressure (Pw) were measured b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30dce0ffad2b5f9857cf2964e5ca07c
https://doi.org/10.4103/2045-8932.94836
https://doi.org/10.4103/2045-8932.94836
Autor:
Michael S. Mulligan, Wayne J. E. Lamm, David K. Madtes, Barry E. Storer, Billanna Hwang, Kraig Abrams, George E. Georges, Richard A. Nash, Robert Glenny
Publikováno v:
Transplantation. 101:e326-e327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba778ba4c68f287b9e4823f5fd1d5a7e
https://doi.org/10.1097/tp.0000000000001868
https://doi.org/10.1097/tp.0000000000001868
Autor:
Kraig Abrams, Richard A. Nash, Murad Yunosov, Robert C. Hackman, Rainer Storb, David K. Madtes, Stephen F. Ziegler, Cristina Castilla-Llorente, Billanna Hwang, Julie Randolph-Habecker, Hans D. Ochs, Barry E. Storer, Alexander S. Farivar, Michael S. Mulligan, Marina Lesnikova, George E. Georges, Peter Chen, Robb W. Glenny, Wayne J. E. Lamm
Publikováno v:
American Journal of Transplantation. 9:1037-1047
Long-term survival after lung transplantation is limited by acute and chronic graft rejection. Induction of immune tolerance by first establishing mixed hematopoietic chimerism (MC) is a promising strategy to improve outcomes. In a preclinical canine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483691b3de08e830ce63b6d8d154dd40
https://doi.org/10.1111/j.1600-6143.2009.02619.x
https://doi.org/10.1111/j.1600-6143.2009.02619.x
Publikováno v:
Respiratory Physiology & Neurobiology. 159:76-84
Studies in whole animals, isolated lungs and pulmonary tissue strips have shown that the pulmonary vascular resistance (PVR) to hypoxia is temporally biphasic in nature. We studied the regional temporal response to hypoxia in prone pigs. The animals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0c6cd0c69464d9704095ecc2b62170
https://doi.org/10.1016/j.resp.2007.05.015
https://doi.org/10.1016/j.resp.2007.05.015