Zobrazeno 1 - 10
of 48
pro vyhledávání: '"J E, Holden"'
Autor:
D, Murali, T E, Barnhart, N T, Vandehey, B T, Christian, R J, Nickles, A K, Converse, J A, Larson, J E, Holden, M L, Schneider, O T, Dejesus
Publikováno v:
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 72
A simple synthesis of the dopamine transporter ligand [(18)F]FECNT with high radiochemical yield and short synthesis time, suitable for routine production is reported. Reaction of 2β-carbomethoxy-3β-(4-chlorophenyl)nortropane with [(18)F]2-fluoroet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c86e3b8ef0fa979df8423507c46e226
https://pubmed.ncbi.nlm.nih.gov/23208243
https://pubmed.ncbi.nlm.nih.gov/23208243
Publikováno v:
Synapse (New York, N.Y.). 39(1)
The effect of aging on aromatic L-amino acid decarboxylase (AAAD) activity in rhesus monkey striatum was assessed in vivo using PET imaging. Two analogs of L-DOPA, 6-fluoro-m-tyrosine (FMT) and 6-fluoro-L-DOPA (FDOPA), were used to image rhesus monke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f16c1ef32f1a11c97d4b3d3f94203372
https://pubmed.ncbi.nlm.nih.gov/11071710
https://pubmed.ncbi.nlm.nih.gov/11071710
Publikováno v:
Synapse (New York, N.Y.). 38(2)
Studies of dopamine (DA) receptor binding in early parkinsonian patients, or in models of Parkinson's disease, have revealed a supersensitivity of the D2-like receptor subtype as compared to age-matched controls. The lack of upregulation in advanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c01ba8e4ba3f7d8041377faf5c55104
https://pubmed.ncbi.nlm.nih.gov/11018784
https://pubmed.ncbi.nlm.nih.gov/11018784
Autor:
C S, Lee, A, Samii, V, Sossi, T J, Ruth, M, Schulzer, J E, Holden, J, Wudel, P K, Pal, R, de la Fuente-Fernandez, D B, Calne, A J, Stoessl
Publikováno v:
Annals of neurology. 47(4)
Clinical symptoms of Parkinson's disease (PD) do not manifest until dopamine (DA) neuronal loss reaches a symptomatic threshold. To explore the mechanisms of functional compensation that occur in presynaptic DA nerve terminals in PD, we compared stri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c17358ec517f0f1eba199ba0f7cd9681
https://pubmed.ncbi.nlm.nih.gov/10762161
https://pubmed.ncbi.nlm.nih.gov/10762161
Publikováno v:
Magnetic resonance in medicine. 43(1)
Undersampled projection reconstruction (PR) is investigated as an alternative method for MRA (MR angiography). In conventional 3D Fourier transform (FT) MRA, resolution in the phase-encoding direction is proportional to acquisition time. Since the PR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f63c2931b52684ce8f79a5896939d5ef
https://pubmed.ncbi.nlm.nih.gov/10642735
https://pubmed.ncbi.nlm.nih.gov/10642735
Autor:
G L, Chan, J E, Holden, A J, Stoessl, A, Samii, D J, Doudet, T, Dobko, K S, Morrison, M, Adam, M, Schulzer, D B, Calne, T J, Ruth
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(2)
The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y.The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd6209517f2629475ab4a2853e505ed4
https://pubmed.ncbi.nlm.nih.gov/10025836
https://pubmed.ncbi.nlm.nih.gov/10025836
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(11)
This article presents dosimetry based on the measurement of fluoro-DOPA activity in major tissues and in the bladder contents in humans after oral pretreatment with 100 mg carbidopa.Bladder activity was measured continuously by external probe and cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3461ea0378a1623320ae5878ccfb6222
https://pubmed.ncbi.nlm.nih.gov/9829576
https://pubmed.ncbi.nlm.nih.gov/9829576
Autor:
M E, Emborg, S Y, Ma, E J, Mufson, A I, Levey, M D, Taylor, W D, Brown, J E, Holden, J H, Kordower
Publikováno v:
The Journal of comparative neurology. 401(2)
Although the role of dopamine dysfunction is well established in Parkinson's disease, the effect of nigrostriatal degeneration on motor performance during normal aging is less well understood. In this study, aged rhesus monkeys (25-27 years old) disp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95007d4b1ea36cd86572f7da3313130d
https://pubmed.ncbi.nlm.nih.gov/9822152
https://pubmed.ncbi.nlm.nih.gov/9822152
Autor:
B, Renstrom, S, Rommelfanger, C K, Stone, T R, DeGrado, K J, Carlson, E, Scarbrough, R J, Nickles, A J, Liedtke, J E, Holden
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(10)
To study the sensitivity of two fatty acid tracers to changes in beta-oxidation, the myocardial retention kinetics of 125I-iodine-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) and 14-18F-fluoro-6-thia-heptadecanoic acid (FTHA) were compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b0620db575a3344d6bad8367731d23b
https://pubmed.ncbi.nlm.nih.gov/9776269
https://pubmed.ncbi.nlm.nih.gov/9776269
Autor:
C K, Stone, R A, Pooley, T R, DeGrado, B, Renstrom, R J, Nickles, S H, Nellis, A J, Liedtke, J E, Holden
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(10)
The fatty acid tracer 14-18F-fluoro-6-thia-heptadecanoic acid (FTHA) is a metabolically trapped tracer of exogenous fatty acid utilization. The objectives of this study were to determine the relationship of FTHA uptake to changes in perfusion and fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d8b8010af9c2a34c2223e6a6bef4994
https://pubmed.ncbi.nlm.nih.gov/9776270
https://pubmed.ncbi.nlm.nih.gov/9776270