Zobrazeno 1 - 10
of 65
pro vyhledávání: '"J E, Groopman"'
Autor:
M S, Kunzi, J E, Groopman
Publikováno v:
Blood. 81:3336-3342
Impaired megakaryocytopoiesis may be a contributing factor to thrombocytopenia associated with human immunodeficiency virus (HIV) infection. Because HIV isolates differ in their host range and pathogenicity, we investigated whether HIV strains with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb6ae99ac63eeaccc57eed650d4c004
https://doi.org/10.1182/blood.v81.12.3336.bloodjournal81123336
https://doi.org/10.1182/blood.v81.12.3336.bloodjournal81123336
Publikováno v:
Blood. 80:1679-1684
Human kit ligand (KL), also known as stem cell factor (SCF), steel factor, or mast cell growth factor, is a recently identified hematopoietic growth factor whose receptor is the product of the c-kit proto-oncogene. Alternative splicing of the pre-mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5579d55ccffbdf6888147bc96b78d4
https://doi.org/10.1182/blood.v80.7.1679.1679
https://doi.org/10.1182/blood.v80.7.1679.1679
Autor:
J E, Groopman
Publikováno v:
Clinical Infectious Diseases. 12:S500-S506
Patients may be intolerant of zidovudine for several reasons, the most prominent being hematologic toxicity. In vitro studies demonstrate that zidovudine is toxic to the myeloid and erythroid precursors in the bone marrow; at concentrations of zidovu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7d17f514e4760de638c7d0d8319bc9
https://doi.org/10.1093/clinids/12.supplement_5.s500
https://doi.org/10.1093/clinids/12.supplement_5.s500
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 12(4)
Chemokines effect leukocyte chemotaxis and activation through their binding to specific G protein-coupled receptors. Although early steps in chemokine signal transduction pathways have been characterized, there is relatively limited information avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5c51bcc993a5d4ef2cbb9947cb2a74e
https://pubmed.ncbi.nlm.nih.gov/11331250
https://pubmed.ncbi.nlm.nih.gov/11331250
Publikováno v:
Blood. 95(8)
The stromal cell-derived factor-1 (SDF-1) is an alpha chemokine that binds to the CXCR4 receptor. Knock-out studies in mice demonstrate that this ligand-receptor pair is essential in hematopoiesis. One function of SDF-1 appears to be the regulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f8cd6244d9fc894d165f3133d1c59d8
https://pubmed.ncbi.nlm.nih.gov/10753828
https://pubmed.ncbi.nlm.nih.gov/10753828
Publikováno v:
Blood. 96(4)
The immune dysfunction and cell destruction that occur in the human immunodeficiency virus (HIV)-infected host appear to result from the direct cytopathic effects of viral infection and the effects of viral proteins on uninfected bystander cells. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23c4c4e0e1538b558f08d17fd3693dc7
https://pubmed.ncbi.nlm.nih.gov/10942389
https://pubmed.ncbi.nlm.nih.gov/10942389
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(7)
Stromal cell-derived factor (SDF-1alpha), the ligand for CXCR4, is a chemokine that acts as a potent chemoattractant for hemopoietic progenitor cells. Stem cell factor/kit ligand (SCF/KL), an early acting cytokine, has recently been reported to enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c90eec35e350e1117354a94054d3986b
https://pubmed.ncbi.nlm.nih.gov/9759889
https://pubmed.ncbi.nlm.nih.gov/9759889
Publikováno v:
Blood. 92(3)
CXCR4 is the receptor for the alpha-chemokine stromal cell-derived factor 1 (SDF-1) and has been shown to be expressed on a diversity of leukocytes. In this report, the expression of the CXCR4 receptor in cells of megakaryocytic lineage and the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8aeefe3b57b307763e0e942bad8b31fe
https://pubmed.ncbi.nlm.nih.gov/9680341
https://pubmed.ncbi.nlm.nih.gov/9680341
Publikováno v:
Blood. 91(10)
RAFTK, a novel nonreceptor protein kinase, has been shown to be involved in focal adhesion signal transduction pathways in neuronal PC12 cells, megakaryocytes, platelets, and T cells. Because focal adhesions may modulate cytoskeletal functions and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ecce0cdaee5603062e9e1cac5cadd32
https://pubmed.ncbi.nlm.nih.gov/9573036
https://pubmed.ncbi.nlm.nih.gov/9573036
Autor:
J E, Groopman
Publikováno v:
Oncology (Williston Park, N.Y.). 12(3)
Fatigue is a common and troubling symptom in patients with cancer or HIV/AIDS, resulting in significant disability and adverse effects on quality of life. Its etiology remains complex and is most likely multifactorial. Despite its impact and prevalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3590a23c41ccd1df0aa5881baa689b6
https://pubmed.ncbi.nlm.nih.gov/9534184
https://pubmed.ncbi.nlm.nih.gov/9534184