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Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat

Autor: F F, Sun, P S, Lai, G, Yue, K, Yin, R G, Nagele, D M, Tong, R F, Krzesicki, J E, Chin, P Y, Wong

Publikováno v: Inflammation. 25(1)

We examined the mRNA expression of cytokines, chemokines, integrins, and selectins in colon lesions of rat colitis with a semi-quantitative RT-PCR assay. Rat colitis was induced by trinitrobenzene sulfonic acid (TNBS) in 50% ethanol. Within 24 h, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af8f0d63e79e1822482ae4e72e449d77
https://pubmed.ncbi.nlm.nih.gov/11293664

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Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma

Autor: J E, Chin, C A, Hatfield, G E, Winterrowd, R F, Krzesicki, K L, Shull, S F, Fidler, K P, Kolbasa, J R, Brashler, R L, Griffin, W E, Fleming, J M, Justen, L S, Banitt, G L, Bundy, I M, Richards

Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(1)

The anti-inflammatory properties of a novel pyrrolopyrimidine, PNU-142731A, in a murine model of antigen-induced eosinophilic lung inflammation are described. PNU-142731A, when given orally, demonstrated a dose-related inhibition of eosinophil- and l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::513c34a80c0895f815c9f4a616865c11
https://pubmed.ncbi.nlm.nih.gov/10381775

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Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling

Autor: J E, Chin, M, Dickens, J M, Tavare, R A, Roth

Publikováno v: The Journal of biological chemistry. 268(9)

Chinese hamster ovary cells overexpressing the human insulin receptor were transfected with cDNAs encoding protein kinase C isoenzymes alpha, beta I, gamma, and epsilon as well as an inactive alpha. Overexpression of these protein kinase Cs did not a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d461eda93bc1d048457e1f0a234aa5b
https://pubmed.ncbi.nlm.nih.gov/8454604

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Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts

Autor: J E, Chin, G E, Winterrowd, R F, Krzesicki, M E, Sanders

Publikováno v: Arthritis and rheumatism. 33(12)

This study was undertaken in an effort to understand the role of cytokines in T lymphocyte trafficking into inflamed synovium and in the potential enhancement of antigen presentation by human synovial fibroblasts. We found that interleukin-1 beta (IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e9470a19cf1872b9a513892e3a79a17
https://pubmed.ncbi.nlm.nih.gov/1701992

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