Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J E, Axelson"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(2)
Previous estimates of maternal and fetal placental and nonplacental clearances in pregnant sheep using a two-compartment open model have revealed higher values of fetal placental clearance (CLfm) compared to the maternal placental clearance (CLmf) fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f7ed49c2bd64e01bae1485a105888b1
https://pubmed.ncbi.nlm.nih.gov/9262323
https://pubmed.ncbi.nlm.nih.gov/9262323
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(3)
In this study, two factors that could affect fetal drug exposure were examined: 1) the extent of elimination of drug delivered to the fetal liver from the placenta via the umbilical vein; and 2) the degree to which there is preferential distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7baa41a36ed3abe1fad76db00fa748c1
https://pubmed.ncbi.nlm.nih.gov/8820416
https://pubmed.ncbi.nlm.nih.gov/8820416
Publikováno v:
NIDA research monograph. 154
The development of more sensitive and selective analytical techniques has greatly improved scientists' ability to study the PK, PD, and metabolism of drugs in pregnancy. This chapter has chronicled the evolution of the study of drug disposition in pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::714c49dcbdc439afef25f9c899846aad
https://pubmed.ncbi.nlm.nih.gov/8606744
https://pubmed.ncbi.nlm.nih.gov/8606744
Autor:
K, Yeleswaram, D W, Rurak, E, Kwan, C, Hall, A, Doroudian, M R, Wright, F S, Abbott, J E, Axelson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(1)
Labetalol has been previously shown to cause significant maternal and fetal metabolic effects in pregnant sheep after maternal administration. To investigate these observations further, the present study describes the pharmacokinetics, metabolism and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f08c805ef7f5813c175a7aa84e3f3ba
https://pubmed.ncbi.nlm.nih.gov/8229771
https://pubmed.ncbi.nlm.nih.gov/8229771
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(2)
Labetalol causes significant maternal and fetal metabolic effects in pregnant sheep (Yeleswaram et al., J. Pharmacol. Exp. Ther. 262, 683-691 (1992)). This study was undertaken to investigate the contribution of skeletal muscles in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b025427f502e1b0aab5e60df1ad2889f
https://pubmed.ncbi.nlm.nih.gov/8097698
https://pubmed.ncbi.nlm.nih.gov/8097698
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(2)
The maternal-fetal disposition of labetalol, a combined alpha-1 and beta adrenergic blocker, and its pharmacodynamics in pregnancy are not well understood. This study describes the pharmacokinetics, cardiovascular and metabolic effects of labetalol i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb390de6183e8bd77d2a0e0bcae1523d
https://pubmed.ncbi.nlm.nih.gov/1501116
https://pubmed.ncbi.nlm.nih.gov/1501116
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(1)
Ritodrine infusion to fetal lambs causes numerous metabolic perturbations including hypoxemia. To investigate these changes further and to elucidate a mechanism for the development of hypoxemia, ritodrine was infused at rate of 2.6 micrograms/min int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f93005c30d5e44ed7c9bfb2448ab6fd
https://pubmed.ncbi.nlm.nih.gov/1625213
https://pubmed.ncbi.nlm.nih.gov/1625213
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 258(3)
The disposition of the beta-2 adrenoreceptor agonist, ritodrine, has been examined in the fetal lamb during and after constant rate fetal intravenous infusion (8-24 h). Samples were collected from the fetal femoral artery, umbilical vein, maternal fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcbb4ee42bfb9eaab241df812a568d8f
https://pubmed.ncbi.nlm.nih.gov/1890624
https://pubmed.ncbi.nlm.nih.gov/1890624
Publikováno v:
Journal of developmental physiology. 15(1)
Surveys of drug use in pregnancy demonstrate that a significant proportion of human fetuses are exposed to prescription and non-prescription drugs antenatally or during labor, although recently a decrease in licit drug consumption during pregnancy ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ab0c31935a908347caf84eb114c0cfd
https://pubmed.ncbi.nlm.nih.gov/1678754
https://pubmed.ncbi.nlm.nih.gov/1678754
Publikováno v:
Research communications in chemical pathology and pharmacology. 67(3)
Quantitation of tocainide carbamoyl-O-B-D-glucuronide, a major metabolite of the antiarrhythmic agent, tocainide, was previously reported using sodium hydroxide hydrolysis (pH greater than 12) of the glucuronide followed by gas chromatographic analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26fda649ed98b1f30e419a4b3f646efa
https://pubmed.ncbi.nlm.nih.gov/2111573
https://pubmed.ncbi.nlm.nih.gov/2111573