Zobrazeno 1 - 10
of 7 864
pro vyhledávání: '"J De Leon"'
Autor:
Yihao Guo, Liangdong Zhou, Yi Li, Gloria C. Chiang, Tao Liu, Huijuan Chen, Weiyuan Huang, Mony J. de Leon, Yi Wang, Feng Chen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Quantitative transport mapping (QTM) of blood velocity, based on the transport equation has been demonstrated higher accuracy and sensitivity of perfusion quantification than the traditional Kety’s method-based cerebral blood fl
Externí odkaz:
https://doaj.org/article/14c5fbddc8344df2b21dd365eb46ff4c
Autor:
Tovia Jacobs, Sean R. Jacobson, Juan Fortea, Jeffrey S. Berger, Alok Vedvyas, Karyn Marsh, Tianshe He, Eugenio Gutierrez-Jimenez, Nathanael R. Fillmore, Moses Gonzalez, Luisa Figueredo, Naomi L. Gaggi, Chelsea Reichert Plaska, Nunzio Pomara, Esther Blessing, Rebecca Betensky, Henry Rusinek, Henrik Zetterberg, Kaj Blennow, Lidia Glodzik, Thomas M. Wisniweski, Mony J. de Leon, Ricardo S. Osorio, Jaime Ramos-Cejudo, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background An elevated neutrophil–lymphocyte ratio (NLR) in blood has been associated with Alzheimer’s disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting inves
Externí odkaz:
https://doaj.org/article/64735eb95a84489b999f38452eb3aac9
Autor:
Neel H. Mehta, Xiuyuan Wang, Samantha A. Keil, Ke Xi, Liangdong Zhou, Kevin Lee, Wanbin Tan, Edward Spector, Amirhossein Goldan, James Kelly, Nicolas A. Karakatsanis, P. David Mozley, Sadek Nehmeh, J. Levi Chazen, Simon Morin, John Babich, Jana Ivanidze, Silky Pahlajani, Emily B. Tanzi, Leslie Saint-Louis, Tracy Butler, Kewei Chen, Henry Rusinek, Roxana O. Carare, Yi Li, Gloria C. Chiang, Mony J. de Leon
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging data it remains unkn
Externí odkaz:
https://doaj.org/article/038120f6c203440699043248097157ee
Autor:
Anna M. Chen, Martin Gajdošík, Wajiha Ahmed, Sinyeob Ahn, James S. Babb, Esther M. Blessing, Allal Boutajangout, Mony J. de Leon, Ludovic Debure, Naomi Gaggi, Mia Gajdošík, Ajax George, Mobeena Ghuman, Lidia Glodzik, Patrick Harvey, Christoph Juchem, Karyn Marsh, Rosemary Peralta, Henry Rusinek, Sulaiman Sheriff, Alok Vedvyas, Thomas Wisniewski, Helena Zheng, Ricardo Osorio, Ivan I. Kirov
Publikováno v:
NeuroImage, Vol 297, Iss , Pp 120742- (2024)
ABSTRACT: Purpose: The pathological hallmarks of Alzheimer's disease (AD), amyloid, tau, and associated neurodegeneration, are present in the cortical gray matter (GM) years before symptom onset, and at significantly greater levels in carriers of the
Externí odkaz:
https://doaj.org/article/df54edeec1d44a40b0c054d4676011a6
Autor:
B. Pedemonte, C. W. Pereira, V. Borghesani, M. Ebbert, I. E. Allen, P. Pinheiro-Chagas, J. De Leon, Z. Miller, B. L. Tee, M. L. Gorno-Tempini
Publikováno v:
npj Science of Learning, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Despite a high rate of concurrent mathematical difficulties among children with dyslexia, we still have limited information regarding the prevalence and severity of mathematical deficits in this population. To address this gap, we developed
Externí odkaz:
https://doaj.org/article/86d967f90f0844b1a556f998035942ee
Autor:
Liangdong Zhou, Yi Li, Elizabeth M. Sweeney, Xiuyuan H. Wang, Amy Kuceyeski, Gloria C. Chiang, Jana Ivanidze, Yi Wang, Susan A. Gauthier, Mony J. de Leon, Thanh D. Nguyen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Background and purposeOur objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20–80 years to study the effect of aging on the parenchymal CSF fraction (CSFF), a potential measure of the subvoxel CSF space.
Externí odkaz:
https://doaj.org/article/0bb2151f3dfb410aad3fcac1a34e9636
Autor:
Anna S. Nordvig, Mangala Rajan, Jennifer D. Lau, Justin R. Kingery, Meem Mahmud, Gloria C. Chiang, Mony J. De Leon, Parag Goyal
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
ImportanceThe U.S. government has named post-acute sequelae of COVID-19 (longCOVID) as influential on disability rates. We previously showed that COVID-19 carries a medical/functional burden at 1 year, and that age and other risk factors of severe CO
Externí odkaz:
https://doaj.org/article/b695dbd9b3924920a0b9a06d1ead1546
Autor:
Yi Li, Henry Rusinek, Tracy Butler, Lidia Glodzik, Elizabeth Pirraglia, John Babich, P. David Mozley, Sadek Nehmeh, Silky Pahlajani, Xiuyuan Wang, Emily B. Tanzi, Liangdong Zhou, Sara Strauss, Roxana O. Carare, Neil Theise, Nobuyuki Okamura, Mony J. de Leon
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-9 (2022)
Abstract Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is not well established in living humans. CSF clearance, a major feature
Externí odkaz:
https://doaj.org/article/4885e6645f9045a8868a02d6ab9e11d9
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-4 (2022)
Abstract Background Myoclonus-dystonia is a rare movement disorder with an autosomal dominant inheritance pattern characterized by a combination of myoclonic jerks and dystonia that may have psychiatric manifestations. Our aim is to present neurologi
Externí odkaz:
https://doaj.org/article/d936928c38524d429c2de9a0c164cb0f
Autor:
Esther M. Blessing, Ankit Parekh, Rebecca A. Betensky, James Babb, Natalie Saba, Ludovic Debure, Andrew W. Varga, Indu Ayappa, David M. Rapoport, Tracy A. Butler, Mony J. de Leon, Thomas Wisniewski, Brian J. Lopresti, Ricardo S. Osorio
Publikováno v:
Neurobiology of Disease, Vol 171, Iss , Pp 105748- (2022)
Background: Preclinical studies suggest body temperature (Tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in Alzheimer's Disease (AD). Tau phosphorylation is substantially increased by a small (
Externí odkaz:
https://doaj.org/article/dccf07f08d5e400ab5e17b4071c2f542