Zobrazeno 1 - 10
of 14
pro vyhledávání: '"J David Pajerowski"'
Autor:
James M Wagner, J David Pajerowski, Christopher L Daniels, Patrick M McHugh, Jessica A Flynn, John W Balliet, Danilo R Casimiro, Shyamsundar Subramanian
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94401 (2014)
Chikungunya virus-like particles (VLPs) have potential to be used as a prophylactic vaccine based on testing in multiple animal models and are currently being evaluated for human use in a Phase I clinical trial. The current method for producing these
Externí odkaz:
https://doaj.org/article/de84d5cc23ff4b7a97129b9a9cf8fabb
Autor:
Dennis E. Discher, Karthikan Rajagopal, Abdullah Mahmud, Sharon M. Loverde, André Ex Brown, J. David Pajerowski, David A. Christian
Publikováno v:
Macromolecules. 43:9736-9746
Crystallization processes are in general sensitive to detailed conditions, but our present understanding of underlying mechanisms is insufficient. A crystallizable chain within a diblock copolymer assembly is expected to couple curvature to crystalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d15a90b5243dc72954fdce200bc184
https://doi.org/10.1021/ma101316w
https://doi.org/10.1021/ma101316w
Autor:
J. David Pajerowski, Diana M. Bowen, Younghoon Kim, David A. Christian, Shenshen Cai, Dennis E. Discher
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 71:463-474
Polymersomes are polymer-based vesicular shells that form upon hydration of amphiphilic block copolymers. These high molecular weight amphiphiles impart physicochemical properties that allow polymersomes to stably encapsulate or integrate a broad ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db0018a9fbac86e2af30ea33924643e
https://doi.org/10.1016/j.ejpb.2008.09.025
https://doi.org/10.1016/j.ejpb.2008.09.025
Autor:
Younghoon, Kim, Manorama, Tewari, J David, Pajerowski, Shenshen, Cai, Shamik, Sen, Jason H, Williams, Jason, Williams, Shashank R, Sirsi, Shashank, Sirsi, Gordon J, Lutz, Gordon, Lutz, Dennis E, Discher
Publikováno v:
Journal of Controlled Release. 134:132-140
siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers-but exposed positive charge is problematic in vivo. Here we demonstrate loading and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2f229442095aa9a76660eea660d6e1
https://doi.org/10.1016/j.jconrel.2008.10.020
https://doi.org/10.1016/j.jconrel.2008.10.020
Publikováno v:
Proceedings of the National Academy of Sciences. 104:15619-15624
Cell differentiation in embryogenesis involves extensive changes in gene expression structural reorganization within the nucleus, including chromatin condensation and nucleoprotein immobilization. We hypothesized that nuclei in naive stem cells would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb17757bb14a00468b7a3556d5b60b1
https://doi.org/10.1073/pnas.0702576104
https://doi.org/10.1073/pnas.0702576104
Publikováno v:
Biophysical Journal. 89:2855-2864
Force-induced changes in genome expression as well as remodeling of nuclear architecture in development and disease motivate a deeper understanding of nuclear mechanics. Chromatin and green fluorescent protein-lamin B dynamics were visualized in a mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0dc4ac9f4cfcafae81bc1b32176ede
https://doi.org/10.1529/biophysj.105.062554
https://doi.org/10.1529/biophysj.105.062554
Autor:
Amnon Buxboim, J. David Pajerowski, David W. Speicher, Joel Pinter, Joe Swift, Manorama Tewari, Florian Rehfeldt, Dennis E. Discher, P.C. Dave P. Dingal, Irena L. Ivanovska, Takamasa Harada, Kyle R. Spinler, Jae-Won Shin
Publikováno v:
Science (New York, N.Y.). 341(6149)
Label-free quantitation and characterization of proteins by mass spectrometry (MS) is now feasible, especially for moderately expressed structural proteins such as lamins that typically yield dozens of tryptic peptides from tissue cells. Using standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcd43f705d5ff5e3886cc2ecba85829
https://pubmed.ncbi.nlm.nih.gov/24448480
https://pubmed.ncbi.nlm.nih.gov/24448480
Publikováno v:
Methods in cell biology. 98
The genome is virtually identical in all cells within an organism, with epigenetic changes contributing largely to the plasticity in gene expression during both development and aging. These changes include covalent modifications of chromatin componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71883d41a4db7bd3564842407ca4d4e
https://pubmed.ncbi.nlm.nih.gov/20816236
https://pubmed.ncbi.nlm.nih.gov/20816236
Autor:
J. David Pajerowski, David W. Speicher, Brian C. Chase, Dennis E. Discher, Hsin-Yao Tang, Diego A. Pantano
Publikováno v:
Biophysical Journal. 100:371a
Protein unfolding, disassembly, and aggregation underlie many diseases, but detailed study of these processes in intact cells has been limited. Cysteine Shotgun labeling utilizes cell-permeable fluorescent dyes to label exposed cysteine residues and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b362069c6701f9a8e3b43da78cc8b1a
https://doi.org/10.1016/j.bpj.2010.12.2211
https://doi.org/10.1016/j.bpj.2010.12.2211
Autor:
David W. Speicher, J. David Pajerowski, Joe Swift, Brian C. Chase, Hsin-Yao Tang, Diego A. Pantano, Dennis E. Discher
Publikováno v:
Biophysical Journal. 98:447a
The study of protein folding and stability is typically conducted with purified proteins by methods that are exacting but lack the ability to analyze complex mixtures of proteins. To study proteins in their native environments inside a cell or isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ac2571498994844590507a6c44bd9c
https://doi.org/10.1016/j.bpj.2009.12.2431
https://doi.org/10.1016/j.bpj.2009.12.2431