Zobrazeno 1 - 10
of 45
pro vyhledávání: '"J David Becherer"'
Autor:
Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intrac
Externí odkaz:
https://doaj.org/article/6c250288d3cf48f0b41fe25918c4ad63
Autor:
Bharat Lagu, Xinyuan Wu, Santosh Kulkarni, Rakesh Paul, J. David Becherer, Lyndsay Olson, Stella Ravani, Athanasia Chatzianastasiou, Andreas Papapetropoulos, Sylvia Andrzejewski
Publikováno v:
Journal of Medicinal Chemistry. 65:9418-9446
Autor:
Ping-Min Chen, Eri Katsuyama, Abhigyan Satyam, Hao Li, Jose Rubio, Sungwook Jung, Sylvia Andrzejewski, J. David Becherer, Maria G. Tsokos, Reza Abdi, George C. Tsokos
Publikováno v:
Science advances. 8(24)
Infection is one of the major causes of mortality in patients with systemic lupus erythematosus (SLE). We previously found that CD38, an ectoenzyme that regulates the production of NAD+, is up-regulated in CD8+T cells of SLE patients and correlates w
Autor:
J. David Becherer, Sparks Steven, Dana P Danger, Tony Leesnitzer, Robert J. Schotzinger, Christopher M. Yates, William J. Hoekstra
Publikováno v:
ACS Med Chem Lett
[Image: see text] Excess aldosterone production and signaling are primary contributors to numerous cardiovascular disorders including primary aldosteronism and resistant hypertension. Recently, inhibition of aldosterone synthesis via the enzyme aldos
Autor:
Bertram Pitt, John S. Lee, Sparks Steven, Karen Morris, J. David Becherer, Robert Shotzinger, William J. Hoekstra, Deepak L. Bhatt
Publikováno v:
Hypertension. 76
Aldosterone is an important mineralocorticoid responsible for fluid and electrolyte homeostasis produced by aldosterone synthase (CYP11B2). An aldosterone synthase inhibitor (ASI) may be a therapeutic option for primary aldosteronism-related conditio
Autor:
William J. Hoekstra, Sparks Steven, Edward P. Garvey, Robert J. Schotzinger, J. David Becherer
Publikováno v:
Journal of the Endocrine Society
Primary aldosteronism (PA) is a common form of secondary hypertension driven by the autonomous production of aldosterone. Often described as low-renin hypertension, PA is a major public health concern given its prevalence and associated cardiovascula
Autor:
J. David Becherer, Jason A Holt, Edward P. Garvey, Robert J. Schotzinger, William J. Hoekstra, Christopher M. Yates
Publikováno v:
Blood. 132:3215-3215
Despite recent advances, disease progression and treatment resistance in multiple myeloma (MM) remains a significant challenge. Current therapies include proteasome inhibitors, immunomodulatory agents, monoclonal antibodies and more recently histone
Autor:
Susan P Weaver, Sarva M. Tadepalli, Channa K Jayawickreme, Lihong Chen, George R. Szewczyk, Maite de los Frailes, Mythily Vimal, Brian Budzik, Thomas J. Rimele, Sean Ross, Susan Armour, David Moncol, Don L. Anderson, Francisco Javier Colilla, Michael R. Jeune, David D. Wisnoski, Karen A. Evans, Ralph A. Rivero, Zibin B Chen, J. David Becherer, Todd W Shearer, Jian Jin, Robert J. Griffin
Publikováno v:
Journal of Medicinal Chemistry. 52:7962-7965
A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent small molecule agonists of the human TGR5 G-protein coupled receptor is described. Subsequent optimization resulted in the rapid identifi
Autor:
Mary H. Hanlon, Aaron B. Miller, David J.T. Porter, Kevin P. Madauss, J. David Becherer, Robert A. Reid, Caroline J. Diaz, Luke H. Carter, A.M. Hassell, Curt D. Haffner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4360-4363
We report the synthesis and in vitro activity of a series of novel pyrrolidinyl pyridones and pyrazinones as potent inhibitors of prolyl oligopeptidase (POP). Within this series, compound 39 was co-crystallized within the catalytic site of a human ch
Autor:
Christie Schulte, Curt D. Haffner, J. Chuck Poole, Eric E. Boros, John C. Ulrich, David J. Cowan, Tiffany Carpenter, Eugene L. Stewart, J. Darren Stuart, Frank Preugschat, David N. Deaton, Tara Renae Rheault, Todd W. Shearer, Barry G. Shearer, J. David Becherer, Michael R. Jeune, Istvan Kaldor, Lisa M. Shewchuk, Terrence L. Smalley
Publikováno v:
Journal of medicinal chemistry. 58(17)
Starting from the micromolar 8-quinoline carboxamide high-throughput screening hit 1a, a systematic exploration of the structure-activity relationships (SAR) of the 4-, 6-, and 8-substituents of the quinoline ring resulted in the identification of ap