Zobrazeno 1 - 10
of 275
pro vyhledávání: '"J David, Sweatt"'
Autor:
Shane G. Poplawski, Krassimira A. Garbett, Rebekah L. McMahan, Holly B. Kordasiewicz, Hien Zhao, Andrew J. Kennedy, Slavina B. Goleva, Teresa H. Sanders, S. Timothy Motley, Eric E. Swayze, David J. Ecker, J. David Sweatt, Todd P. Michael, Celeste B. Greer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1399-1412 (2020)
Knockout of the memory suppressor gene histone deacetylase 2 (Hdac2) in mice elicits cognitive enhancement, and drugs that block HDAC2 have potential as therapeutics for disorders affecting memory. Currently available HDAC2 catalytic activity inhibit
Externí odkaz:
https://doaj.org/article/663dff1bf29f4ebeac30337a05a1aae1
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying change in the underlying genomic sequence. A number of studies in animal models have shown that dysregulation of various component
Externí odkaz:
https://doaj.org/article/faaad56028474fe78efd312e7914a343
Autor:
Andrew J. Kennedy, Elizabeth J. Rahn, Brynna S. Paulukaitis, Katherine E. Savell, Holly B. Kordasiewicz, Jing Wang, John W. Lewis, Jessica Posey, Sarah K. Strange, Mikael C. Guzman-Karlsson, Scott E. Phillips, Kyle Decker, S. Timothy Motley, Eric E. Swayze, David J. Ecker, Todd P. Michael, Jeremy J. Day, J. David Sweatt
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2666-2685 (2016)
Human haploinsufficiency of the transcription factor Tcf4 leads to a rare autism spectrum disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language impairment and development delay. Here, we demonstrate that Tcf4 haploins
Externí odkaz:
https://doaj.org/article/b3ced49ba885434ea78334ce9770d0f4
Autor:
Katherine E. Savell, Nancy V. N. Gallus, Rhiana C. Simon, Jordan A. Brown, Jasmin S. Revanna, Mary Katherine Osborn, Esther Y. Song, John J. O’Malley, Christian T. Stackhouse, Allison Norvil, Humaira Gowher, J. David Sweatt, Jeremy J. Day
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
DNA methylation in the brain is a dynamic process, but gene-specific regulation of this process is poorly understood. Here, Day and colleagues show that extra-coding RNAs interact with DNA methyltransferases and regulate neuronal DNA methylation to c
Externí odkaz:
https://doaj.org/article/7d938d2a579f49edb66b0941663590e6
Autor:
J. David Sweatt
This book stands as the first unified overview of the cellular and molecular mechanisms underlying higher-order learning and memory. It integrates modern discoveries concerning learning and memory disorders such as mental retardation syndromes and Al
Autor:
Lara Ianov, Matt De Both, Monica K. Chawla, Asha Rani, Andrew J. Kennedy, Ignazio Piras, Jeremy J. Day, Ashley Siniard, Ashok Kumar, J. David Sweatt, Carol A. Barnes, Matthew J. Huentelman, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
The current study employed next-generation RNA sequencing to examine gene expression differences related to brain aging, cognitive decline, and hippocampal subfields. Young and aged rats were trained on a spatial episodic memory task. Hippocampal reg
Externí odkaz:
https://doaj.org/article/7f174db43057465d9cea4d44290dcdc8
Autor:
Fumiaki Yokoi, Huan-Xin Chen, Mai Tu Dang, Chad C Cheetham, Susan L Campbell, Steven N Roper, J David Sweatt, Yuqing Li
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120916 (2015)
DYT1 dystonia is an inherited movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Most of the patients have a trinucleotide deletion (ΔGAG) corresponding to a glutamic acid in the C-terminal region (torsinA(ΔE)). Dyt1 Δ
Externí odkaz:
https://doaj.org/article/f358a7afcaec458fbca1b68aab27d38b
Autor:
J. David Sweatt, Joseph Weiss, Luke Hogewood, Lan Chen, Rebekah L. McMahan, Casey Paton, Teresa H. Sanders
Publikováno v:
The Journal of Neuroscience. :2407-18
Vagus nerve stimulation (VNS) has been shown to enhance learning and memory, yet the mechanisms behind these enhancements are unknown. Here, we present evidence that epigenetic modulation underlies VNS-induced improvements in cognition. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd06febc026c048bf6b6f359a9499aa
https://doi.org/10.1523/jneurosci.2407-18.2019
https://doi.org/10.1523/jneurosci.2407-18.2019
Autor:
J. David Sweatt
Publikováno v:
Current Opinion in Behavioral Sciences. 25:51-56
This commentary reviews the concept of experience-dependent epigenetic modifications in the CNS as a core mechanism underlying individuality and individuation at the behavioral level. I use the term individuation to refer to the underlying neurobiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30aaba67e1308f2c6e65679a5a6b40b4
https://doi.org/10.1016/j.cobeha.2018.06.009
https://doi.org/10.1016/j.cobeha.2018.06.009
Autor:
David B. Allison, Lisa H. Antoine, Scott W. Ballinger, Marcas M. Bamman, Peggy Biga, Victor M. Darley-Usmar, Gordon Fisher, Julia M. Gohlke, Ganesh V. Halade, John L. Hartman, Gary R. Hunter, Joseph L. Messina, Tim R. Nagy, Eric P. Plaisance, Mickie L. Powell, Kevin A. Roth, Michael W. Sandel, Tonia S. Schwartz, Daniel L. Smith, J. David Sweatt, Trygve O. Tollefsbol, Stephen A. Watts, Yongbin Yang, Jianhua Zhang, Steven N. Austad
Publikováno v:
F1000Research, Vol 3 (2014)
Background: As part of a coordinated effort to expand our research activity at the interface of Aging and Energetics a team of investigators at The University of Alabama at Birmingham systematically assayed and catalogued the top research priorities
Externí odkaz:
https://doaj.org/article/4087876e59e449788ef13b813f1aaa9c