Zobrazeno 1 - 10
of 36
pro vyhledávání: '"J D Waterfield"'
Publikováno v:
Journal of biomedical materials research. Part A. 105(9)
Recognition of topographical features induces phenotypic changes in macrophages although the receptors and signaling pathways are not completely characterized. As integrin molecules in focal adhesions/podosomes are in intimate contact with topography
The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model
Publikováno v:
Rheumatology. 38:1068-1073
Objective. Mice of the MRL-lpr strain develop a severe autoimmune arthritic condition when primed with complete Freund's adjuvant. The pathology is similar to that seen in human rheumatoid arthritis. We investigated whether PK 11195, a powerful ligan
Publikováno v:
Biopharmaceutics & Drug Disposition. 19:395-400
Photodynamic therapy (PDT) using the photosensitizer BPD-Verteporfin (liposomal benzoporphyrin derivative-monoacid ring A) has been shown in previous studies to be effective in the amelioration of inflammatory arthritis in both the MRL-lpr mouse and
Publikováno v:
Rheumatology. 36:174-177
Our objective was to investigate IgG glycosylation and disease activity post partum in the MRL-lpr/lpr mouse. Disease activity was monitored using bimalleolar ankle swelling. Levels of galactose and N-acetylglucosamine (GlcNAc) on IgG isolated from s
Publikováno v:
Clinical and Experimental Immunology. 98:52-59
SUMMARY Sixty-eight percent of female MRL-lpr- mice developed a post-partum exacerbation of their mild spontaneous arthritis within 30 days of parturition- The flare became evident between 5 and 15 days after delivery. Histologically it was character
Autor:
R K Chowdhary, Modestus Obochi, J G Levy, Anna M. Richter, J D Waterfield, Herma C. Neyndorff, Leslie G. Ratkay
Publikováno v:
Clinical Immunology and Immunopathology. 72:255-263
The use of transcutaneous photodynamic therapy (PDT) has been investigated in the prevention of adjuvant enhanced arthritis in MRL/lpr mice. Mice receiving adjuvant were treated with PDT at 10-day intervals starting on the day of adjuvant administrat
Publikováno v:
Clinical and Experimental Immunology. 95:373-377
SUMMARY Although numerous experimentat immunomodulalory regimens have been reported to be effective in the treatment of rheumatoid arthritis, they also produce undesirable side effects. An alternative specific modality of localized treatment is photo
Publikováno v:
The Journal of Immunology. 151:5081-5087
A study was performed on the effect of CFA on the spontaneous arthritis of MRL-lpr mice. The development of swelling and erythema was monitored for 1 mo after injecting 13- to 14-wk-old mice intradermally with CFA, at which time the histopathology of
Publikováno v:
Clinical Immunology and Immunopathology. 59:236-245
Autoimmune MRL-lpr mice develop a spontaneous arthritis displaying similar articular and extra-articular features to rheumatoid arthritis in humans. In this study we used an ELISA assay to evaluate the serological responses of MRL-lpr mice to select
Publikováno v:
Rheumatology (Oxford, England). 43(1)
OBJECTIVE To investigate the effect of targeting the chemotaxis of monocytes and polymorphonuclear monocytes (PMNs) in situ in MRL-Faslpr arthritis. METHODS MRL-Faslpr mice were injected intradermally with complete Freund's adjuvant and cellular infi