Zobrazeno 1 - 10
of 49
pro vyhledávání: '"J D Robbins"'
Autor:
M. L. Walch, W. D. Thompson, L. B. Cahoon, J. D. Robbins, M. T. Antonini, D. J. Devito, K. D. Marshburn, R. K. Earp, P. J. Blackmon, D. A. Sawyer
Publikováno v:
Journal of North Carolina Academy of Science. 127:259-263
ShellBond is a patented material derived from high temperature treatment of calcareous materials, including oyster shells, yielding a unique form of calcium hydroxide, Ca(OH)2. Previous work with ShellBond showed effects on ammonium and phosphate con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4154e3c970ac908d6053869abb2379
https://doi.org/10.7572/2167-5880-127.4.259
https://doi.org/10.7572/2167-5880-127.4.259
Autor:
Allen R. Braun, Nathan M Appel, Richard E. Carson, Elizabeth Sutkowski, William C. Eckelman, Mark B. Sassaman, J D Robbins, Elaine M. Jagoda, Dale O. Kiesewetter, Peter Herscovitch
Publikováno v:
Journal of Fluorine Chemistry. 101:297-304
We prepared two fluorine containing carbamate analogs of forskolin as potential agents for imaging adenylyl cyclase in the living brain with positron emission tomography. Both compounds display high in vitro affinity for adenylyl cyclase. The radiosy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b8375e0ea43c4efef104c1a9c2fbf99
https://doi.org/10.1016/s0022-1139(99)00174-8
https://doi.org/10.1016/s0022-1139(99)00174-8
Publikováno v:
Journal of Medicinal Chemistry. 39:2745-2752
Three series of analogs were regioselectively prepared from a protected forskolin precursor to afford 7-carbamoyl-7-desacetylforskolins (series 1), 6-carbamoyl-7-desacetylforskolins (series 2), and 6-carbamoylforskolins (series 3). The analogs were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8218ad055b60b0d418cd3bc60600b9f
https://doi.org/10.1021/jm960191+
https://doi.org/10.1021/jm960191+
Publikováno v:
Biochemistry. 33:12852-12859
Several forms of adenylyl cyclase (types I, II, V, and VI) have been expressed using the recombinant baculovirus expression system in Sf9 cells. The activation of type I adenylyl cyclase by forskolin and Gs alpha was not greater than additive. In con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bf70c36b8878e025793594682befcc
https://doi.org/10.1021/bi00209a017
https://doi.org/10.1021/bi00209a017
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 68:147-153
S,S-Disubstituted phosphonotrithioates may be prepared by reaction of phosphonothioic dichlorides with mercaptans in the presence of a catalytic amount of solubilized halide anion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::101ed267885be22fa99b94cc5ad6674e
https://doi.org/10.1080/10426509208038382
https://doi.org/10.1080/10426509208038382
Autor:
Antonio Laurenza, Kenneth B. Seamon, Nathan M. Appel, Errol B. De Souza, J D Robbins, Ian A. Simpson
Publikováno v:
Brain Research. 581:148-152
Two radioiodinated derivatives of forskolin, [125I]6-IHPP-Fsk and [125I]7-IHPP-Fsk, were synthesized as specific ligands for adenylyl cyclase and glucose transporter, respectively. [125I]6-IHPP-Fsk bound to bovine brain homogenates with a Kd of 9 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41211e59ce70e903450d21390794106b
https://doi.org/10.1016/0006-8993(92)90354-c
https://doi.org/10.1016/0006-8993(92)90354-c
Publikováno v:
Journal of Biological Chemistry. 266:13377-13384
Two photolabels, N-(3-(4-azido-3-125I-phenyl)-propionamide)-6- aminoethylcarbamylforskolin(125I-6-AIPP-Fsk) and N-(3-(4-azido-3-125I-phenyl)propionamide)-7-aminoethylcarbamyl-7- desacetylforskolin (125I-7-AIPP-Fsk) were synthesized with specific acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ff6aeba7c3ed58cf6875cf83dd905e
https://doi.org/10.1016/s0021-9258(18)98850-2
https://doi.org/10.1016/s0021-9258(18)98850-2
Publikováno v:
The Journal of Immunology. 146:224-232
Neutrophils (PMN) treated with cAMP elevating agents were evaluated for their chemotactic responsiveness to FMLP and leukotriene B4 (LTB4). PGE1 and isoproterenol, increased PMN cyclic AMP production and inhibited chemotaxis to both FMLP and LTB4. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead6668b4c60e77a01cdcddaffe1df80
https://doi.org/10.4049/jimmunol.146.1.224
https://doi.org/10.4049/jimmunol.146.1.224
Publikováno v:
Molecular pharmacology. 50(2)
Forskolin (Fsk) has been demonstrated to interact directly with the enzyme adenylyl cyclase (EC 4.6.1.1) in diverse tissues. However, the ability of Fsk to bind to and activate adenylyl cyclase varies depending on the tissue being studied. Different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d4596ff93065fd1f0059192ba3974bb
https://pubmed.ncbi.nlm.nih.gov/8700137
https://pubmed.ncbi.nlm.nih.gov/8700137
Publikováno v:
Journal of medicinal chemistry. 39(14)
Three series of analogs were regioselectively prepared from a protected forskolin precursor to afford 7-carbamoyl-7-desacetylforskolins (series 1), 6-carbamoyl-7-desacetylforskolins (series 2), and 6-carbamoylforskolins (series 3). The analogs were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffc4fba47f78ec3e065c52cd66e16554
https://pubmed.ncbi.nlm.nih.gov/8709105
https://pubmed.ncbi.nlm.nih.gov/8709105