Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J D Kursar"'
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 357:17-24
In previous reports, [3H]5-HT has been used to characterize the pharmacology of the rat and human 5-HT2B receptors. 5-HT, the native agonist for the 5-HT2B receptor, has a limitation in its usefulness as a radioligand since it is difficult to study t
Publikováno v:
Obesity Research. 3:441S-447S
Over the last several years the use of molecular cloning technology has revealed a vast diversity among serotonin (5-HT) receptors, whereby what was previously thought to be a family of three pharmacologically defined classes of 5-HT receptors is act
Autor:
S B, Gates, L G, Mendelsohn, K A, Shackelford, L L, Habeck, J D, Kursar, L S, Gossett, J F, Worzalla, C, Shih, G B, Grindey
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(7)
Membrane-associated folate receptors (FRs) have been detected in many mammalian species, and multiple isoforms have been identified. The pharmacological properties of FRs from murine kidney, liver, and six murine tumors were characterized. Murine kid
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(2)
The 5-Hydroxytryptamine2B (5-HT2B) receptor was cloned originally from rat stomach fundus and its pharmacology was determined to be consistent with that of the receptor responsible for contraction of rat fundal tissue in response to 5-HT. Recently, t
A first-in-human phase I study of the oral Notch inhibitor LY900009 in patients with advanced cancer
Autor:
Emma Jones, Carla Kurkjian, Maciej J. Zamek-Gliszczynski, Eunice Yuen, Johanna C. Bendell, D. Scott McMeekin, Suzanne F. Jones, Howard A. Burris, Shubham Pant, Edward M. Chan, J D Kursar, Kathleen N. Moore, Jeffrey R. Infante
Publikováno v:
Journal of Clinical Oncology. 30:3008-3008
3008 Background: Notch signaling plays a critical role during stem cell self-renewal and is deregulated in multiple human cancers. The Notch pathway may be activated inappropriately by receptor mutation and overexpression as well as aberrant signals
Publikováno v:
Molecular pharmacology. 46(2)
Clones encoding a portion of the human 5-hydroxytryptamine (5-HT)2B receptor gene were isolated from a human placental genomic library. Based on distribution studies of 5-HT2B receptor mRNA, human uterus cDNA libraries were constructed and screened,
Autor:
D B, Wainscott, M L, Cohen, K W, Schenck, J E, Audia, J S, Nissen, M, Baez, J D, Kursar, V L, Lucaites, D L, Nelson
Publikováno v:
Molecular pharmacology. 43(3)
The rat 5-hydroxytryptamine (5-HT)2F (serotonin2F) receptor is a newly cloned member of the 5-HT2/1C receptor family. The pharmacology of the 5-HT2F receptor was explored using a variety of structurally different compounds in a radioligand binding as
Publikováno v:
Molecular pharmacology. 42(4)
Using the polymerase chain reaction amplification technique in conjunction with conventional cloning techniques, we have isolated a novel member of the serotonin [5-hydroxytryptamine (5-HT)] 1C/2 receptor subfamily (designated 5-HT2F) from rat stomac
Autor:
Shubham Pant, Maciej J. Zamek-Gliszczynski, Karim A. Benhadji, Howard A. Burris, Carla Kurkjian, Eunice S.M. Yuen, Johanna C. Bendell, D.S. McMeekin, Suzanne F. Jones, Kathleen N. Moore, Martin Frenzel, Jeffrey R. Infante, Bharvin K. R. Patel, J D Kursar, Edward M. Chan
Publikováno v:
European Journal of Cancer. :1-9
Background Notch signalling regulates stem cell development and survival and is deregulated in multiple malignancies. LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. We report the first