Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J D Keene"'
Publikováno v:
The Journal of Immunology. 152:4192-4202
The human Ro ribonucleoprotein is a clinically important yet poorly understood autoantigen. The contribution of Ro autoantibodies to pathogenesis of autoimmune disease remains unclear, as do the stimuli that initiate and maintain the response. Recent
Publikováno v:
The Journal of Immunology. 150:1137-1145
Nucleotide-specific autoimmune epitopes have not been precisely defined despite the fact that certain kinds of DNA and RNA species are known to bind autoantibodies. Our laboratory has used nucleic acid epitope libraries, consisting of randomized RNA
Autor:
R C, Bentley, J D, Keene
Publikováno v:
Molecular and Cellular Biology. 11:1829-1839
We have investigated the sequence elements influencing RNA recognition in two closely related small nuclear ribonucleoprotein particle (snRNP) proteins, U1 snRNP-A and U2 snRNP-B". A 5-amino-acid segment in the RNA-binding domain of the U2 snRNP-B" p
Publikováno v:
The Journal of Immunology. 146:1885-1892
In evaluating the origin of autoantibodies, patterns of self-Ag recognition have been interpreted to reflect the relative role of Ag in stimulating a response. Few studies, however, have assessed whether human autoantibodies display patterns of autoa
Publikováno v:
The Journal of Immunology. 144:3868-3876
Because of increasing evidence suggesting that anti-La autoantibodies are induced in humans by an Ag-specific mechanism, we investigated the antibody response of animals immunized with the human La Ag and studied its relationship to the anti-La respo
Autor:
L G, Andrews, J D, Keene
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 118
Autor:
D J, Kenan, J D, Keene
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 118
Autor:
J D, Keene
Publikováno v:
Methods in enzymology. 267
Publikováno v:
Nucleic acids symposium series. (33)
Hel-N1, is an RRM protein which is a mammalian homologue of the Drosophila melanogaster RNA binding protein, ELAV (embryonic lethal abnormal vision). Hel-N1 binds to RNA containing short stretches of uridylates similar to those found in the 3' untran
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 152(8)
The human Ro ribonucleoprotein is a clinically important yet poorly understood autoantigen. The contribution of Ro autoantibodies to pathogenesis of autoimmune disease remains unclear, as do the stimuli that initiate and maintain the response. Recent